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GCM1 glial cells missing transcription factor 1 [ Homo sapiens (human) ]

Gene ID: 8521, updated on 10-Dec-2024

Summary

Official Symbol
GCM1provided by HGNC
Official Full Name
glial cells missing transcription factor 1provided by HGNC
Primary source
HGNC:HGNC:4197
See related
Ensembl:ENSG00000137270 MIM:603715; AllianceGenome:HGNC:4197
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCMA; hGCMa
Summary
This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein. [provided by RefSeq, Jul 2008]
Expression
Biased expression in placenta (RPKM 5.9), testis (RPKM 0.6) and 1 other tissue See more
Orthologs
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Genomic context

See GCM1 in Genome Data Viewer
Location:
6p12.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (53126961..53148841, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (52966559..52988449, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (52991759..53013639, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17288 Neighboring gene uncharacterized LOC128031835 Neighboring gene F-box protein 9 Neighboring gene RNA, 7SL, cytoplasmic 244, pseudogene Neighboring gene Sharpr-MPRA regulatory region 2296 Neighboring gene uncharacterized LOC124901513 Neighboring gene RNA, U6 small nuclear 464, pseudogene Neighboring gene superoxide dismutase 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in anatomical structure morphogenesis PubMed 
involved_in astrocyte fate commitment  
involved_in branching involved in labyrinthine layer morphogenesis  
involved_in cell differentiation involved in embryonic placenta development  
involved_in gliogenesis  
acts_upstream_of_or_within positive regulation of DNA-templated transcription PubMed 
involved_in positive regulation of syncytium formation by plasma membrane fusion  
involved_in positive regulation of transcription by RNA polymerase II PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription PubMed 
involved_in regulation of cell differentiation involved in embryonic placenta development PubMed 
involved_in regulation of transcription by RNA polymerase II  
involved_in syncytium formation by plasma membrane fusion  
involved_in transcription by RNA polymerase II PubMed 
Component Evidence Code Pubs
located_in chromatin  
is_active_in nucleus  
located_in nucleus PubMed 
part_of transcription regulator complex PubMed 

General protein information

Preferred Names
chorion-specific transcription factor GCMa
Names
GCM motif protein 1
glial cells missing homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003643.4NP_003634.2  chorion-specific transcription factor GCMa

    See identical proteins and their annotated locations for NP_003634.2

    Status: REVIEWED

    Source sequence(s)
    AB026493, AI219562, AL512347, BC096288, BC096289, D88613
    Consensus CDS
    CCDS4950.1
    UniProtKB/Swiss-Prot
    Q4VAQ7, Q5T0X0, Q99468, Q9NP62, Q9P1X3
    Related
    ENSP00000259803.7, ENST00000259803.8
    Conserved Domains (2) summary
    pfam03615
    Location:30167
    GCM; GCM motif protein
    cl25750
    Location:173237
    DamX; Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    53126961..53148841 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    52966559..52988449 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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