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    Atf4 activating transcription factor 4 [ Mus musculus (house mouse) ]

    Gene ID: 11911, updated on 24-Dec-2024

    Summary

    Official Symbol
    Atf4provided by MGI
    Official Full Name
    activating transcription factor 4provided by MGI
    Primary source
    MGI:MGI:88096
    See related
    Ensembl:ENSMUSG00000042406 AllianceGenome:MGI:88096
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Atf-4; C/ATF; CREB2; CREB-2; TAXREB67
    Summary
    Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding protein binding activity; and promoter-specific chromatin binding activity. Contributes to DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including cellular response to leucine starvation; intracellular signal transduction; and regulation of gene expression. Acts upstream of or within several processes, including gluconeogenesis; positive regulation of sodium-dependent phosphate transport; and positive regulation of vascular associated smooth muscle cell apoptotic process. Located in cytoplasm and nucleus. Part of ATF1-ATF4 transcription factor complex and ATF4-CREB1 transcription factor complex. Is expressed in several structures, including central nervous system; embryo ectoderm; eye; genitourinary system; and long bone. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human ATF4 (activating transcription factor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 153.4), liver E14.5 (RPKM 138.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Atf4 in Genome Data Viewer
    Location:
    15 E1; 15 37.85 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (80139385..80141746)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (80255184..80257545)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39231 Neighboring gene predicted gene, 46521 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene mitochondrial elongation factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E11599 Neighboring gene ribosomal protein S19 binding protein 1 Neighboring gene calcium channel, voltage-dependent, alpha 1I subunit Neighboring gene predicted gene, 31319

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (10)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC96460

    Gene Ontology Provided by MGI

    Items 1 - 25 of 33
    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables DNA binding  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity  
    contributes_to DNA-binding transcription factor activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor binding  
    contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables cAMP response element binding protein binding PubMed 
    enables general transcription initiation factor binding  
    enables general transcription initiation factor binding  
    enables identical protein binding  
    enables identical protein binding  
    enables leucine zipper domain binding  
    enables leucine zipper domain binding  
    enables promoter-specific chromatin binding PubMed 
    enables promoter-specific chromatin binding PubMed 
    enables protein binding PubMed 
    enables protein heterodimerization activity PubMed 
    enables protein kinase binding  
    enables protein kinase binding  
    enables sequence-specific DNA binding  
    enables sequence-specific double-stranded DNA binding  
    contributes_to transcription cis-regulatory region binding  
    enables transcription cis-regulatory region binding  
    Items 1 - 25 of 33
    Items 1 - 25 of 71
    Process Evidence Code Pubs
    involved_in HRI-mediated signaling  
    involved_in HRI-mediated signaling  
    involved_in L-asparagine metabolic process  
    involved_in L-asparagine metabolic process  
    involved_in PERK-mediated unfolded protein response PubMed 
    involved_in PERK-mediated unfolded protein response PubMed 
    involved_in bone mineralization PubMed 
    involved_in cellular response to amino acid starvation PubMed 
    involved_in cellular response to amino acid starvation PubMed 
    involved_in cellular response to glucose starvation  
    involved_in cellular response to glucose starvation  
    involved_in cellular response to hypoxia  
    involved_in cellular response to leucine starvation PubMed 
    involved_in cellular response to leucine starvation PubMed 
    involved_in cellular response to oxidative stress PubMed 
    involved_in cellular response to oxidative stress  
    involved_in circadian regulation of gene expression PubMed 
    involved_in circadian rhythm PubMed 
    involved_in embryonic hemopoiesis PubMed 
    involved_in endoplasmic reticulum unfolded protein response PubMed 
    involved_in gamma-aminobutyric acid signaling pathway  
    involved_in gamma-aminobutyric acid signaling pathway  
    acts_upstream_of_or_within gluconeogenesis PubMed 
    involved_in integrated stress response signaling PubMed 
    involved_in integrated stress response signaling  
    acts_upstream_of_or_within intracellular calcium ion homeostasis PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress PubMed 
    involved_in lens fiber cell morphogenesis PubMed 
    involved_in mRNA transcription by RNA polymerase II PubMed 
    involved_in negative regulation of cold-induced thermogenesis PubMed 
    involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  
    involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  
    involved_in negative regulation of potassium ion transport  
    involved_in negative regulation of potassium ion transport  
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in neuron differentiation  
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    acts_upstream_of_or_within positive regulation of biomineral tissue development PubMed 
    acts_upstream_of_or_within positive regulation of gene expression PubMed 
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of gene expression  
    involved_in positive regulation of neuron apoptotic process PubMed 
    acts_upstream_of_or_within positive regulation of sodium-dependent phosphate transport PubMed 
    involved_in positive regulation of transcription by RNA polymerase I  
    involved_in positive regulation of transcription by RNA polymerase I  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of vascular associated smooth muscle cell apoptotic process PubMed 
    involved_in positive regulation of vascular endothelial growth factor production  
    involved_in positive regulation of vascular endothelial growth factor production  
    acts_upstream_of_or_within regulation of DNA-templated transcription PubMed 
    involved_in regulation of DNA-templated transcription PubMed 
    involved_in regulation of osteoblast differentiation PubMed 
    involved_in regulation of osteoblast differentiation  
    involved_in regulation of synaptic plasticity PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II PubMed 
    involved_in regulation of transcription by RNA polymerase II PubMed 
    involved_in response to endoplasmic reticulum stress PubMed 
    involved_in response to endoplasmic reticulum stress PubMed 
    involved_in response to endoplasmic reticulum stress  
    involved_in response to manganese-induced endoplasmic reticulum stress  
    involved_in response to nutrient levels  
    involved_in response to toxic substance  
    acts_upstream_of transcription by RNA polymerase II PubMed 
    Items 1 - 25 of 71
    Items 1 - 20 of 32
    Component Evidence Code Pubs
    part_of ATF1-ATF4 transcription factor complex  
    part_of ATF1-ATF4 transcription factor complex PubMed 
    part_of ATF1-ATF4 transcription factor complex  
    part_of ATF4-CREB1 transcription factor complex  
    part_of ATF4-CREB1 transcription factor complex PubMed 
    part_of ATF4-CREB1 transcription factor complex  
    part_of CHOP-ATF4 complex  
    part_of CHOP-ATF4 complex  
    located_in Lewy body core  
    located_in Lewy body core  
    part_of RNA polymerase II transcription regulator complex PubMed 
    part_of RNA polymerase II transcription regulator complex PubMed 
    part_of RNA polymerase II transcription regulator complex  
    located_in centrosome  
    colocalizes_with centrosome  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in dendrite membrane  
    located_in dendrite membrane  
    located_in neuron projection  
    located_in nuclear periphery  
    located_in nuclear periphery  
    located_in nuclear speck  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in nucleus PubMed 
    part_of protein-containing complex  
    part_of protein-containing complex PubMed 
    part_of transcription regulator complex PubMed 
    Items 1 - 20 of 32

    General protein information

    Preferred Names
    cyclic AMP-dependent transcription factor ATF-4
    Names
    c/EBP-related ATF
    cAMP-dependent transcription factor ATF-4
    cAMP-responsive element-binding protein 2
    cyclic AMP-responsive element-binding protein 2
    tax-responsive enhancer element-binding protein 67 homolog
    taxREB67 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287180.1NP_001274109.1  cyclic AMP-dependent transcription factor ATF-4

      See identical proteins and their annotated locations for NP_001274109.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal segment in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA003141, AK003001, BC085169, BE992821
      Consensus CDS
      CCDS37145.1
      UniProtKB/Swiss-Prot
      Q06507, Q5U4B2, Q61906
      UniProtKB/TrEMBL
      Q3U2J1
      Conserved Domains (1) summary
      cd14692
      Location:277339
      bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain
    2. NM_009716.3NP_033846.2  cyclic AMP-dependent transcription factor ATF-4

      See identical proteins and their annotated locations for NP_033846.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK003001, BC085169, BE992821
      Consensus CDS
      CCDS37145.1
      UniProtKB/Swiss-Prot
      Q06507, Q5U4B2, Q61906
      UniProtKB/TrEMBL
      Q3U2J1
      Related
      ENSMUSP00000105234.4, ENSMUST00000109605.5
      Conserved Domains (1) summary
      cd14692
      Location:277339
      bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      80139385..80141746
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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