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ena enabled [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37201, updated on 27-Dec-2024

Summary

Official Symbol
enaprovided by FlyBase
Official Full Name
enabledprovided by FlyBase
Primary source
FLYBASE:FBgn0000578
Locus tag
Dmel_CG15112
See related
AllianceGenome:FB:FBgn0000578
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15112; Dmel\CG15112; Ena; ENA/VASP; Enabled; enb; Enb; l(2)02029; Vasp; VASP
Summary
Enables SH3 domain binding activity. Involved in several processes, including embryonic development via the syncytial blastoderm; plasma membrane bounded cell projection organization; and regulation of plasma membrane bounded cell projection assembly. Located in several cellular components, including filopodium tip; lamellipodium; and subsynaptic reticulum. Colocalizes with adherens junction. Is expressed in several structures, including epithelial cell; epithelium; ganglia; neuron projection bundle of larval ventral nerve cord; and somatic trunk mesoderm derivative. Orthologous to several human genes including ENAH (ENAH actin regulator). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See ena in Genome Data Viewer
Location:
56B5-56C1; 2-88 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19141632..19163705)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15029137..15051210)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43399 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene happyhour

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables SH3 domain binding PubMed 
enables SH3 domain binding PubMed 
enables protein binding PubMed 
Items 1 - 25 of 28
Process Evidence Code Pubs
involved_in actin cytoskeleton organization PubMed 
involved_in actin filament organization PubMed 
involved_in actin polymerization or depolymerization  
involved_in axon guidance  
involved_in axon guidance PubMed 
involved_in axon guidance PubMed 
involved_in axonogenesis PubMed 
involved_in border follicle cell migration PubMed 
involved_in compound eye development PubMed 
involved_in dendrite morphogenesis PubMed 
involved_in dorsal closure PubMed 
involved_in epithelial cell morphogenesis PubMed 
involved_in filopodium assembly PubMed 
involved_in formation of a compartment boundary PubMed 
involved_in germ-band shortening PubMed 
involved_in gonad morphogenesis PubMed 
involved_in head involution PubMed 
involved_in negative regulation of synaptic assembly at neuromuscular junction PubMed 
involved_in ovarian nurse cell to oocyte transport PubMed 
involved_in positive regulation of cell migration PubMed 
involved_in positive regulation of cell projection organization PubMed 
involved_in positive regulation of cell projection organization PubMed 
involved_in positive regulation of filopodium assembly PubMed 
involved_in regulation of actin cytoskeleton organization PubMed 
involved_in regulation of filopodium assembly PubMed 
involved_in regulation of lamellipodium assembly PubMed 
involved_in subsynaptic reticulum organization PubMed 
involved_in suture of dorsal opening PubMed 
Items 1 - 25 of 28
Component Evidence Code Pubs
colocalizes_with adherens junction PubMed 
located_in axon PubMed 
located_in cell leading edge PubMed 
colocalizes_with cell-cell junction PubMed 
located_in dendrite PubMed 
is_active_in filopodium tip  
located_in filopodium tip PubMed 
is_active_in focal adhesion  
located_in lamellipodium PubMed 
is_active_in plasma membrane  
located_in subsynaptic reticulum PubMed 

General protein information

Preferred Names
enabled
Names
CG15112-PA
CG15112-PB
CG15112-PC
CG15112-PD
CG15112-PE
CG15112-PF
CG15112-PG
VASP
ena-PA
ena-PB
ena-PC
ena-PD
ena-PE
ena-PF
ena-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    19141632..19163705
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299673.1NP_001286602.1  enabled, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286602.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LFX0
    Conserved Domains (2) summary
    cd01207
    Location:5112
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:629663
    VASP_tetra; VASP tetramerization domain
  2. NM_166330.2NP_725858.1  enabled, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725858.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T4F7
    Related
    FBpp0085766
    Conserved Domains (2) summary
    cd01207
    Location:5112
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:649683
    VASP_tetra; VASP tetramerization domain
  3. NM_001014536.2NP_001014536.1  enabled, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014536.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T4F7
    Conserved Domains (2) summary
    cd01207
    Location:5112
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:649683
    VASP_tetra; VASP tetramerization domain
  4. NM_166329.2NP_725857.1  enabled, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725857.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T4F7
    Related
    FBpp0085767
    Conserved Domains (2) summary
    cd01207
    Location:5112
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:649683
    VASP_tetra; VASP tetramerization domain
  5. NM_001014537.3NP_001014537.1  enabled, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014537.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T4F7
    Conserved Domains (2) summary
    cd01207
    Location:5112
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:652686
    VASP_tetra; VASP tetramerization domain
  6. NM_001144237.2NP_001137709.1  enabled, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137709.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZP3, B7YZL0, Q24035, Q86NN6, Q8MMB3, Q8T4F7, Q9V8R3
    Conserved Domains (2) summary
    cd01207
    Location:301408
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:945979
    VASP_tetra; VASP tetramerization domain
  7. NM_166331.3NP_725859.2  enabled, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725859.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T4F7
    Conserved Domains (2) summary
    cd01207
    Location:150257
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:799833
    VASP_tetra; VASP tetramerization domain
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