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    Gria1 glutamate receptor, ionotropic, AMPA1 (alpha 1) [ Mus musculus (house mouse) ]

    Gene ID: 14799, updated on 17-Dec-2024

    Summary

    Official Symbol
    Gria1provided by MGI
    Official Full Name
    glutamate receptor, ionotropic, AMPA1 (alpha 1)provided by MGI
    Primary source
    MGI:MGI:95808
    See related
    Ensembl:ENSMUSG00000020524 AllianceGenome:MGI:95808
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Glr1; Glr-1; GluA1; GluRA; Glur1; HIPA1; GluR-A; Glur-1; gluR-K1; 2900051M01Rik
    Summary
    Enables AMPA glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in long-term memory; receptor internalization; and synapse assembly. Acts upstream of or within cellular response to ammonium ion; chemical synaptic transmission; and long-term synaptic depression. Located in several cellular components, including dendrite membrane; neuron spine; and perisynaptic space. Part of AMPA glutamate receptor complex. Is active in excitatory synapse; glutamatergic synapse; and synaptic membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Used to study schizoaffective disorder. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder; autosomal recessive intellectual developmental disorder 76; and epilepsy. Orthologous to human GRIA1 (glutamate ionotropic receptor AMPA type subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 40.2), cerebellum adult (RPKM 32.5) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Gria1 in Genome Data Viewer
    Location:
    11 B1.3; 11 34.51 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (56902342..57221070)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (57011571..57330244)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46261 Neighboring gene STARR-seq mESC enhancer starr_29563 Neighboring gene STARR-seq mESC enhancer starr_29564 Neighboring gene predicted gene, 39826 Neighboring gene STARR-seq mESC enhancer starr_29566 Neighboring gene STARR-seq mESC enhancer starr_29569 Neighboring gene STARR-seq mESC enhancer starr_29570 Neighboring gene STARR-positive B cell enhancer mm9_chr11:56989490-56989791 Neighboring gene ribosomal protein S6 pseudogene Neighboring gene predicted gene, 53706

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 48
    Function Evidence Code Pubs
    enables AMPA glutamate receptor activity  
    enables AMPA glutamate receptor activity PubMed 
    enables AMPA glutamate receptor activity  
    enables AMPA glutamate receptor activity  
    enables G-protein alpha-subunit binding  
    enables G-protein alpha-subunit binding  
    enables G-protein beta-subunit binding  
    enables G-protein beta-subunit binding  
    enables PDZ domain binding  
    enables PDZ domain binding  
    enables adenylate cyclase binding  
    enables adenylate cyclase binding  
    enables amyloid-beta binding  
    enables amyloid-beta binding  
    enables beta-2 adrenergic receptor binding  
    enables beta-2 adrenergic receptor binding  
    enables glutamate receptor binding  
    enables glutamate receptor binding  
    enables glutamate-gated calcium ion channel activity  
    enables glutamate-gated calcium ion channel activity  
    enables glutamate-gated receptor activity PubMed 
    enables glutamate-gated receptor activity  
    enables identical protein binding  
    enables identical protein binding  
    enables immunoglobulin binding  
    enables immunoglobulin binding  
    enables ionotropic glutamate receptor binding  
    enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential  
    enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential  
    enables myosin V binding  
    enables myosin V binding  
    enables neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration  
    enables peptide hormone receptor binding  
    enables peptide hormone receptor binding  
    enables protein binding PubMed 
    enables protein domain specific binding  
    enables protein kinase A binding  
    enables protein kinase A binding  
    enables protein kinase binding  
    enables protein kinase binding  
    enables scaffold protein binding  
    enables scaffold protein binding  
    enables small GTPase binding  
    enables small GTPase binding  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential PubMed 
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential PubMed 
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
    Items 1 - 25 of 48
    Items 1 - 25 of 58
    Process Evidence Code Pubs
    involved_in behavioral response to pain  
    involved_in calcium-mediated signaling  
    involved_in cellular response to L-glutamate  
    involved_in cellular response to amine stimulus  
    acts_upstream_of_or_within cellular response to ammonium ion PubMed 
    involved_in cellular response to brain-derived neurotrophic factor stimulus  
    involved_in cellular response to brain-derived neurotrophic factor stimulus  
    involved_in cellular response to dsRNA  
    involved_in cellular response to peptide hormone stimulus  
    involved_in cerebral cortex development  
    acts_upstream_of_or_within chemical synaptic transmission PubMed 
    involved_in conditioned place preference  
    involved_in conditioned place preference  
    involved_in ionotropic glutamate receptor signaling pathway  
    involved_in long-term memory PubMed 
    involved_in long-term memory  
    acts_upstream_of_or_within long-term synaptic depression PubMed 
    involved_in long-term synaptic potentiation  
    involved_in modulation of chemical synaptic transmission  
    involved_in modulation of chemical synaptic transmission  
    involved_in monoatomic ion transmembrane transport  
    involved_in neuronal action potential  
    involved_in neuronal action potential  
    involved_in positive regulation of excitatory postsynaptic potential  
    involved_in positive regulation of excitatory postsynaptic potential  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of locomotion involved in locomotory behavior  
    involved_in positive regulation of locomotion involved in locomotory behavior  
    involved_in positive regulation of membrane potential  
    involved_in positive regulation of membrane potential  
    involved_in positive regulation of synaptic transmission  
    involved_in receptor internalization PubMed 
    involved_in receptor internalization  
    involved_in regulation of monoatomic ion transmembrane transport  
    involved_in regulation of monoatomic ion transmembrane transport  
    involved_in regulation of postsynaptic membrane potential  
    involved_in regulation of presynaptic membrane potential  
    involved_in regulation of receptor recycling  
    involved_in regulation of receptor recycling  
    involved_in regulation of synaptic plasticity  
    involved_in response to arsenic-containing substance  
    involved_in response to cocaine  
    involved_in response to electrical stimulus  
    involved_in response to estradiol  
    involved_in response to ethanol  
    involved_in response to fungicide  
    involved_in response to lithium ion  
    involved_in response to morphine  
    involved_in response to morphine  
    involved_in response to nutrient levels  
    involved_in response to psychosocial stress  
    involved_in response to sucrose  
    involved_in response to toxic substance  
    involved_in response to xenobiotic stimulus  
    involved_in spinal cord development  
    involved_in synapse assembly PubMed 
    involved_in synaptic transmission, glutamatergic  
    Items 1 - 25 of 58
    Items 1 - 20 of 85
    Component Evidence Code Pubs
    part_of AMPA glutamate receptor complex  
    part_of AMPA glutamate receptor complex PubMed 
    part_of AMPA glutamate receptor complex  
    located_in asymmetric synapse  
    located_in axonal spine PubMed 
    located_in cell body PubMed 
    is_active_in cell surface PubMed 
    located_in cell surface PubMed 
    located_in cell surface PubMed 
    located_in cell surface  
    located_in cell-cell junction  
    located_in cell-cell junction  
    located_in cytosol  
    located_in cytosol  
    located_in dendrite PubMed 
    located_in dendrite  
    located_in dendrite membrane PubMed 
    located_in dendrite membrane PubMed 
    located_in dendrite membrane  
    located_in dendritic shaft  
    located_in dendritic shaft  
    is_active_in dendritic spine  
    located_in dendritic spine PubMed 
    located_in dendritic spine  
    is_active_in dendritic spine membrane PubMed 
    located_in dendritic spine membrane  
    located_in early endosome  
    located_in early endosome membrane  
    located_in early endosome membrane  
    located_in endoplasmic reticulum PubMed 
    located_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane  
    is_active_in excitatory synapse PubMed 
    located_in excitatory synapse  
    located_in external side of plasma membrane  
    is_active_in glutamatergic synapse PubMed 
    located_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse  
    part_of ionotropic glutamate receptor complex PubMed 
    located_in membrane PubMed 
    located_in neuromuscular junction  
    located_in neuromuscular junction  
    located_in neuron projection PubMed 
    located_in neuron spine PubMed 
    located_in neuron spine  
    is_active_in neuronal cell body PubMed 
    located_in neuronal cell body PubMed 
    located_in neuronal cell body  
    located_in neuronal cell body membrane  
    located_in neuronal cell body membrane  
    located_in perisynaptic space PubMed 
    is_active_in plasma membrane  
    is_active_in plasma membrane PubMed 
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in postsynapse PubMed 
    located_in postsynaptic density PubMed 
    located_in postsynaptic density  
    is_active_in postsynaptic density membrane  
    is_active_in postsynaptic density membrane PubMed 
    located_in postsynaptic density membrane PubMed 
    is_active_in postsynaptic density membrane  
    located_in postsynaptic density, intracellular component  
    located_in postsynaptic density, intracellular component  
    located_in postsynaptic membrane PubMed 
    is_active_in postsynaptic membrane  
    located_in postsynaptic membrane  
    located_in presynapse PubMed 
    located_in presynaptic active zone membrane  
    is_active_in presynaptic active zone membrane  
    is_active_in presynaptic membrane  
    part_of protein-containing complex  
    located_in proximal dendrite  
    located_in proximal dendrite  
    located_in recycling endosome  
    located_in recycling endosome membrane  
    located_in recycling endosome membrane  
    located_in somatodendritic compartment PubMed 
    located_in synapse PubMed 
    located_in synapse PubMed 
    located_in synaptic membrane PubMed 
    located_in synaptic membrane  
    located_in synaptic vesicle PubMed 
    located_in synaptic vesicle membrane PubMed 
    Items 1 - 20 of 85

    General protein information

    Preferred Names
    glutamate receptor 1
    Names
    AMPA-selective glutamate receptor 1
    glutamate receptor A
    glutamate receptor ionotropic, AMPA 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113325.2NP_001106796.1  glutamate receptor 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001106796.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame exon, compared to variant 2, resulting in a protein (isoform 1) with a distinct internal segment compared to isoform 2.
      Source sequence(s)
      AK049958, AL663055, BC056397
      Consensus CDS
      CCDS48800.1
      UniProtKB/Swiss-Prot
      P23818
      UniProtKB/TrEMBL
      C9K0Y3
      Related
      ENSMUSP00000044494.10, ENSMUST00000036315.16
      Conserved Domains (2) summary
      cd13729
      Location:406787
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06390
      Location:26392
      PBP1_iGluR_AMPA_GluR1; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
    2. NM_001252403.1NP_001239332.1  glutamate receptor 1 isoform 3

      See identical proteins and their annotated locations for NP_001239332.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream, in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK135107, AL672177, BC056397
      Consensus CDS
      CCDS56770.1
      UniProtKB/TrEMBL
      C9K0Y3, F6YNQ1
      Related
      ENSMUSP00000117746.3, ENSMUST00000151045.3
      Conserved Domains (2) summary
      cd13729
      Location:337718
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cl10011
      Location:1323
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
    3. NM_008165.4NP_032191.2  glutamate receptor 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_032191.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame exon, compared to variant 1, resulting in a protein (isoform 2) with a distinct internal segment compared to isoform 1.
      Source sequence(s)
      AL663055, BC056397
      Consensus CDS
      CCDS36159.1
      UniProtKB/TrEMBL
      Q6P9M2, Q7TNB5
      Related
      ENSMUSP00000091731.5, ENSMUST00000094179.11
      Conserved Domains (4) summary
      cd06390
      Location:26389
      PBP1_iGluR_AMPA_GluR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
      cd13729
      Location:406787
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:538817
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:37372
      ANF_receptor; Receptor family ligand binding region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      56902342..57221070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314275.3XP_017169764.1  glutamate receptor 1 isoform X2

      UniProtKB/TrEMBL
      Q6P9M2
      Conserved Domains (2) summary
      cd13729
      Location:337718
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cl10011
      Location:1323
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
    2. XM_006532234.5XP_006532297.1  glutamate receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_006532297.1

      UniProtKB/TrEMBL
      C9K0Y3, F6YNQ1
      Conserved Domains (2) summary
      cd13729
      Location:337718
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cl10011
      Location:1323
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

    RNA

    1. XR_388348.3 RNA Sequence

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