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Doc2b double C2, beta [ Mus musculus (house mouse) ]

Gene ID: 13447, updated on 9-Dec-2024

Summary

Official Symbol
Doc2bprovided by MGI
Official Full Name
double C2, betaprovided by MGI
Primary source
MGI:MGI:1100497
See related
Ensembl:ENSMUSG00000020848 AllianceGenome:MGI:1100497
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
The protein encoded by this gene is a calcium sensor involved in glucose-stimulated insulin secretion, spontaneous neurotransmitter release, and enhanced SNARE-dependent vesicle fusion. [provided by RefSeq, Sep 2015]
Expression
Biased expression in cerebellum adult (RPKM 8.0), adrenal adult (RPKM 5.7) and 11 other tissues See more
Orthologs
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Genomic context

See Doc2b in Genome Data Viewer
Location:
11 B5; 11 45.92 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (75659096..75686886, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (75768270..75796060, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7018 Neighboring gene v-crk avian sarcoma virus CT10 oncogene homolog Neighboring gene STARR-positive B cell enhancer ABC_E3001 Neighboring gene STARR-positive B cell enhancer ABC_E8425 Neighboring gene predicted gene, 57767 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide Neighboring gene STARR-seq mESC enhancer starr_30005 Neighboring gene STARR-positive B cell enhancer ABC_E5247 Neighboring gene STARR-seq mESC enhancer starr_30008 Neighboring gene predicted gene 12339 Neighboring gene rabphilin 3A-like (without C2 domains) Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:75790377-75790632 Neighboring gene STARR-positive B cell enhancer ABC_E10691 Neighboring gene ligand of ATE1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding PubMed 
enables calcium-dependent phospholipid binding  
enables calcium-dependent phospholipid binding  
enables protein binding PubMed 
enables syntaxin binding PubMed 
Process Evidence Code Pubs
involved_in calcium ion-regulated exocytosis of neurotransmitter PubMed 
involved_in calcium ion-regulated exocytosis of neurotransmitter  
involved_in calcium-dependent activation of synaptic vesicle fusion  
involved_in calcium-dependent activation of synaptic vesicle fusion PubMed 
involved_in calcium-dependent activation of synaptic vesicle fusion PubMed 
involved_in calcium-dependent activation of synaptic vesicle fusion  
involved_in positive regulation of calcium ion-dependent exocytosis  
involved_in positive regulation of calcium ion-dependent exocytosis  
involved_in positive regulation of calcium ion-dependent exocytosis  
involved_in positive regulation of insulin secretion PubMed 
involved_in positive regulation of vesicle fusion  
involved_in positive regulation of vesicle fusion  
involved_in protein localization PubMed 
acts_upstream_of_or_within spontaneous neurotransmitter secretion PubMed 
acts_upstream_of_or_within spontaneous neurotransmitter secretion PubMed 
Component Evidence Code Pubs
part_of SNARE complex  
part_of SNARE complex  
located_in cytoplasm PubMed 
is_active_in extrinsic component of synaptic vesicle membrane  
is_active_in glutamatergic synapse  
located_in plasma membrane PubMed 
located_in plasma membrane  
located_in presynapse  
is_active_in synapse  

General protein information

Preferred Names
double C2-like domain-containing protein beta
Names
doc2-beta
double C2 protein beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007873.3NP_031899.2  double C2-like domain-containing protein beta

    See identical proteins and their annotated locations for NP_031899.2

    Status: REVIEWED

    Source sequence(s)
    AL669897, BB624126, BC067030
    Consensus CDS
    CCDS25057.1
    UniProtKB/Swiss-Prot
    P70169, Q5SS41, Q6NXK3
    Related
    ENSMUSP00000021209.8, ENSMUST00000021209.8
    Conserved Domains (2) summary
    cd04035
    Location:127250
    C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
    cd08384
    Location:269401
    C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    75659096..75686886 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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