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SPRY2 sprouty RTK signaling antagonist 2 [ Homo sapiens (human) ]

Gene ID: 10253, updated on 10-Dec-2024

Summary

Official Symbol
SPRY2provided by HGNC
Official Full Name
sprouty RTK signaling antagonist 2provided by HGNC
Primary source
HGNC:HGNC:11270
See related
Ensembl:ENSG00000136158 MIM:602466; AllianceGenome:HGNC:11270
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IGAN3; hSPRY2
Summary
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 17.3), gall bladder (RPKM 13.7) and 25 other tissues See more
Orthologs
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Genomic context

See SPRY2 in Genome Data Viewer
Location:
13q31.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (80335976..80341126, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (79564038..79569188, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (80910111..80915261, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370275 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:80707181-80707680 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:80721652-80721755 Neighboring gene Sharpr-MPRA regulatory region 9192 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr13:80763580-80764573 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr13:80766325-80767524 Neighboring gene uncharacterized LOC101927238 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr13:80792397-80792897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5428 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5429 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:80917085-80917883 Neighboring gene uncharacterized LOC105370276 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:80932978-80933742 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:80933743-80934507 Neighboring gene RNA, U6 small nuclear 61, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
IgA nephropathy, susceptibility to, 3
MedGen: C4225194 OMIM: 616818 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
EBI GWAS Catalog
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.
EBI GWAS Catalog
Genome-wide association study identifies ALLC polymorphisms correlated with FEV₁ change by corticosteroid.
EBI GWAS Catalog
Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate.
EBI GWAS Catalog
Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.
EBI GWAS Catalog
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
EBI GWAS Catalog
Identification of new genetic risk variants for type 2 diabetes.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef SPRY2 upregulation inhibits HIV-1 Gag-, Nef-, and Tat-specific T cell polyfunctionality independently of the PD-1 pathway PubMed
Pr55(Gag) gag SPRY2 upregulation inhibits HIV-1 Gag-, Nef-, and Tat-specific T cell polyfunctionality independently of the PD-1 pathway PubMed
gag SPRY2 interactions with PI(4,5)P2 and PLCgamma allow it to influence HIV-1 Gag release through interference with PI(4,5)P2 dynamics PubMed
gag SPRY-mediated inhibition of HIV-1 Gag release is repressed by IP3R PubMed
gag SPRY2 associates with ESCR-II component EAP20 to promote HIV-1 Gag release PubMed
Tat tat SPRY2 upregulation inhibits HIV-1 Gag-, Nef-, and Tat-specific T cell polyfunctionality independently of the PD-1 pathway PubMed
tat The expression of SPRY2 gene is upregulated in both Jurkat-Tat101 and Jurkat-Tat72 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC23039

Gene Ontology Provided by GOA

Items 1 - 25 of 34
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade  
involved_in animal organ development  
involved_in bud elongation involved in lung branching  
involved_in cell fate commitment  
involved_in cellular response to leukemia inhibitory factor  
involved_in cellular response to vascular endothelial growth factor stimulus PubMed 
involved_in establishment of mitotic spindle orientation  
involved_in fibroblast growth factor receptor signaling pathway  
involved_in inner ear morphogenesis  
involved_in lung growth  
involved_in negative regulation of ERK1 and ERK2 cascade  
involved_in negative regulation of ERK1 and ERK2 cascade PubMed 
involved_in negative regulation of ERK1 and ERK2 cascade PubMed 
involved_in negative regulation of ERK1 and ERK2 cascade  
involved_in negative regulation of Ras protein signal transduction  
involved_in negative regulation of angiogenesis PubMed 
involved_in negative regulation of apoptotic process PubMed 
involved_in negative regulation of cell population proliferation  
involved_in negative regulation of cell projection organization  
involved_in negative regulation of epithelial to mesenchymal transition  
involved_in negative regulation of fibroblast growth factor receptor signaling pathway  
involved_in negative regulation of lens fiber cell differentiation  
involved_in negative regulation of neurotrophin TRK receptor signaling pathway  
involved_in negative regulation of peptidyl-threonine phosphorylation PubMed 
involved_in negative regulation of protein ubiquitination PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway  
involved_in negative regulation of vascular endothelial growth factor signaling pathway PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
involved_in positive regulation of cell migration PubMed 
involved_in positive regulation of epidermal growth factor receptor signaling pathway  
involved_in positive regulation of gene expression PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
involved_in sensory perception of sound  
Items 1 - 25 of 34
Component Evidence Code Pubs
located_in actin cytoskeleton  
located_in cytoskeleton  
is_active_in cytosol  
located_in cytosol  
located_in cytosol  
located_in membrane  
located_in microtubule cytoskeleton  
located_in microtubule end  
located_in nucleus  
located_in plasma membrane  
located_in ruffle membrane  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050650.1 RefSeqGene

    Range
    4990..10140
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001318536.1NP_001305465.1  protein sprouty homolog 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Transcript variants 1-4 encode the same protein.
    Source sequence(s)
    AK313810, BC015745
    Consensus CDS
    CCDS9463.1
    UniProtKB/Swiss-Prot
    B2R9J9, O43597, Q5T6Z7
    UniProtKB/TrEMBL
    Q7Z783
    Conserved Domains (1) summary
    pfam05210
    Location:183284
    Sprouty; Sprouty protein (Spry)
  2. NM_001318537.1NP_001305466.1  protein sprouty homolog 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Transcript variants 1-4 encode the same protein.
    Source sequence(s)
    AL713749, BC015745, DA230586
    Consensus CDS
    CCDS9463.1
    UniProtKB/Swiss-Prot
    B2R9J9, O43597, Q5T6Z7
    UniProtKB/TrEMBL
    Q7Z783
    Related
    ENSP00000366306.1, ENST00000377102.5
    Conserved Domains (1) summary
    pfam05210
    Location:183284
    Sprouty; Sprouty protein (Spry)
  3. NM_001318538.1NP_001305467.1  protein sprouty homolog 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Transcript variants 1-4 encode the same protein.
    Source sequence(s)
    AL713749, BC015745, DA160975, DA230586
    Consensus CDS
    CCDS9463.1
    UniProtKB/Swiss-Prot
    B2R9J9, O43597, Q5T6Z7
    UniProtKB/TrEMBL
    Q7Z783
    Conserved Domains (1) summary
    pfam05210
    Location:183284
    Sprouty; Sprouty protein (Spry)
  4. NM_005842.4NP_005833.1  protein sprouty homolog 2

    See identical proteins and their annotated locations for NP_005833.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Transcript variants 1-4 encode the same protein.
    Source sequence(s)
    AL354668, BC015745, CX866409
    Consensus CDS
    CCDS9463.1
    UniProtKB/Swiss-Prot
    B2R9J9, O43597, Q5T6Z7
    UniProtKB/TrEMBL
    Q7Z783
    Related
    ENSP00000366308.3, ENST00000377104.4
    Conserved Domains (1) summary
    pfam05210
    Location:183284
    Sprouty; Sprouty protein (Spry)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    80335976..80341126 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    79564038..79569188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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