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    Olfm4 olfactomedin 4 [ Mus musculus (house mouse) ]

    Gene ID: 380924, updated on 24-Dec-2024

    Summary

    Official Symbol
    Olfm4provided by MGI
    Official Full Name
    olfactomedin 4provided by MGI
    Primary source
    MGI:MGI:2685142
    See related
    Ensembl:ENSMUSG00000022026 AllianceGenome:MGI:2685142
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GC1; OlfD; pPD4; GW112; Gm296; Gm913
    Summary
    Predicted to enable cadherin binding activity and structural molecule activity. Acts upstream of or within negative regulation of canonical NF-kappaB signal transduction and negative regulation of immune response. Located in extracellular space. Is expressed in bone marrow; colon; intestine; metanephros; and small intestine. Orthologous to human OLFM4 (olfactomedin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in large intestine adult (RPKM 97.6), liver E18 (RPKM 39.9) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Olfm4 in Genome Data Viewer
    Location:
    14 D3; 14 42.78 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (80237742..80260581)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (80000302..80023141)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10845 Neighboring gene predicted gene 6999 Neighboring gene ubiquitin specific peptidase 15 pseudogene Neighboring gene STARR-seq mESC enhancer starr_37271 Neighboring gene protocadherin 8 pseudogene Neighboring gene predicted gene, 31776

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (4)  1 citation

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cadherin binding  
    enables protein binding PubMed 
    enables structural molecule activity  
    Component Evidence Code Pubs
    located_in cytosol  
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in extracellular space  
    located_in intercellular bridge  
    located_in mitochondrion  
    located_in nucleoplasm  
    located_in perinuclear region of cytoplasm  
    located_in plasma membrane  
    part_of protein-containing complex  
    located_in specific granule  

    General protein information

    Preferred Names
    olfactomedin-4
    Names
    OLM4
    PU.1 difference product 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001351947.1NP_001338876.1  olfactomedin-4 precursor

      Status: VALIDATED

      Source sequence(s)
      AK133536, BQ179233
      Consensus CDS
      CCDS36989.2
      UniProtKB/Swiss-Prot
      Q3UZZ4
      UniProtKB/TrEMBL
      B2RUF9, B7ZNU5
      Related
      ENSMUSP00000154285.2, ENSMUST00000228749.2
      Conserved Domains (2) summary
      pfam02191
      Location:243495
      OLF; Olfactomedin-like domain
      pfam04849
      Location:104225
      HAP1_N; HAP1 N-terminal conserved region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      80237742..80260581
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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