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N4BP1 NEDD4 binding protein 1 [ Homo sapiens (human) ]

Gene ID: 9683, updated on 10-Dec-2024

Summary

Official Symbol
N4BP1provided by HGNC
Official Full Name
NEDD4 binding protein 1provided by HGNC
Primary source
HGNC:HGNC:29850
See related
Ensembl:ENSG00000102921 MIM:619138; AllianceGenome:HGNC:29850
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables RNA nuclease activity; mRNA binding activity; and ubiquitin binding activity. Involved in cellular response to UV and negative regulation of viral genome replication. Predicted to be located in cytosol and nucleolus. Predicted to be active in PML body. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in lung (RPKM 13.3), esophagus (RPKM 11.1) and 25 other tissues See more
Orthologs
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Genomic context

See N4BP1 in Genome Data Viewer
Location:
16q12.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (48538726..48610180, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (54336403..54407853, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (48572637..48644091, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene molybdenum cofactor synthesis 1 pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:48562077-48562253 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10795 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10797 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:48572485-48572984 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:48575532-48576032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:48576033-48576533 Neighboring gene Sharpr-MPRA regulatory region 9701 Neighboring gene ribosomal protein S2 pseudogene 44 Neighboring gene probable ribosome biogenesis protein RLP24 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10798 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7457 Neighboring gene uncharacterized LOC124903687 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10800 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10801 Neighboring gene Sharpr-MPRA regulatory region 15629 Neighboring gene uncharacterized LOC105371240 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:48663187-48663688 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:48663689-48664188 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis.
EBI GWAS Catalog
Genome-wide association study of autistic-like traits in a general population study of young adults.
EBI GWAS Catalog

Interactions

General gene information

Clone Names

  • FLJ31821, KIAA0615, MGC176730

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA nuclease activity PubMed 
enables mRNA binding PubMed 
enables protein binding PubMed 
enables ubiquitin binding PubMed 
Component Evidence Code Pubs
is_active_in PML body  
located_in PML body  
located_in cytosol  
located_in cytosol  
located_in nucleolus  
is_active_in nucleus  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153029.4NP_694574.3  NEDD4-binding protein 1

    See identical proteins and their annotated locations for NP_694574.3

    Status: VALIDATED

    Source sequence(s)
    AB014515, AK026937, AK056383, AK124782, AL831882, BC051897
    Consensus CDS
    CCDS45479.1
    UniProtKB/Swiss-Prot
    A7MD49, O75113, Q2YDX1
    Related
    ENSP00000262384.3, ENST00000262384.4
    Conserved Domains (1) summary
    pfam11977
    Location:616769
    RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    48538726..48610180 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523482.2XP_011521784.1  NEDD4-binding protein 1 isoform X1

    Conserved Domains (1) summary
    pfam11977
    Location:616746
    RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

RNA

  1. XR_007064930.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    54336403..54407853 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314484.1XP_054170459.1  NEDD4-binding protein 1 isoform X1

RNA

  1. XR_008484752.1 RNA Sequence

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