U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

trf-1 TNF Receptor Associated Factor (TRAF) homolog [ Caenorhabditis elegans ]

Gene ID: 176767, updated on 9-Dec-2024

Summary

Official Symbol
trf-1
Official Full Name
TNF Receptor Associated Factor (TRAF) homolog
Primary source
WormBase:WBGene00006612
Locus tag
CELE_F45G2.6
See related
AllianceGenome:WB:WBGene00006612
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable signaling adaptor activity. Involved in defense response to Gram-negative bacterium and innate immune response. Predicted to be active in cytoplasm. Is expressed in tail and in male. Human ortholog(s) of this gene implicated in brain disease. Orthologous to several human genes including TRAF4 (TNF receptor associated factor 4). [provided by Alliance of Genome Resources, Dec 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See trf-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
12
Sequence:
Chromosome: III; NC_003281.10 (13430462..13433438)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Myosin motor domain-containing protein;Myosin_tail_1 domain-containing protein Neighboring gene Exonuclease 1 Neighboring gene Coatomer subunit epsilon Neighboring gene Kunitz-type protein bli-5 Neighboring gene COMM domain-containing protein Neighboring gene Mitochondrial import inner membrane translocase subunit tim-16

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables signaling adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of plasma membrane signaling receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
TNF Receptor Associated Factor (TRAF) homolog
NP_499773.2
  • Product from WormBase gene class trf;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    13430462..13433438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067372.5NP_499773.2  TNF Receptor Associated Factor (TRAF) homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499773.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EG80
    Conserved Domains (2) summary
    cd00270
    Location:264412
    MATH_TRAF_C; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link cell surface TNFRs and receptors of the interleukin-1/Toll-like family to downstream kinase ...
    pfam02176
    Location:152210
    zf-TRAF; TRAF-type zinc finger