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    Rala v-ral simian leukemia viral oncogene A (ras related) [ Mus musculus (house mouse) ]

    Gene ID: 56044, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ralaprovided by MGI
    Official Full Name
    v-ral simian leukemia viral oncogene A (ras related)provided by MGI
    Primary source
    MGI:MGI:1927243
    See related
    Ensembl:ENSMUSG00000008859 AllianceGenome:MGI:1927243
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ral; Rasl1; 3010001O15Rik
    Summary
    Enables GTPase activity. Involved in membrane raft localization; neural tube closure; and regulation of exocytosis. Located in myelin sheath. Is expressed in several structures, including alimentary system; central nervous system; eye; heart; and skin. Orthologous to human RALA (RAS like proto-oncogene A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 28.4), CNS E14 (RPKM 21.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Rala in Genome Data Viewer
    Location:
    13 A2; 13 6.05 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (18055160..18118802, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (17880575..17944217, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24018 Neighboring gene predicted gene, 18859 Neighboring gene STARR-seq mESC enhancer starr_33765 Neighboring gene ADP-ribosylation factor 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_33767 Neighboring gene G patch domain and ankyrin repeats 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7206 Neighboring gene Yae1 domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding  
    enables ATPase binding  
    enables Edg-2 lysophosphatidic acid receptor binding  
    enables Edg-2 lysophosphatidic acid receptor binding  
    enables G protein activity  
    enables GDP binding  
    enables GDP binding  
    enables GDP binding  
    enables GTP binding  
    enables GTP binding  
    enables GTP binding  
    enables GTPase activity PubMed 
    enables GTPase activity  
    enables GTPase activity  
    enables myosin binding  
    enables myosin binding  
    enables protein binding PubMed 
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction  
    involved_in Ras protein signal transduction  
    involved_in Ras protein signal transduction  
    involved_in cell division  
    involved_in establishment of protein localization to mitochondrion  
    involved_in establishment of protein localization to mitochondrion  
    involved_in exocytosis  
    involved_in membrane raft localization PubMed 
    involved_in membrane raft localization  
    involved_in neural tube closure PubMed 
    involved_in positive regulation of epidermal growth factor receptor signaling pathway  
    involved_in positive regulation of epidermal growth factor receptor signaling pathway  
    involved_in positive regulation of filopodium assembly  
    involved_in positive regulation of filopodium assembly  
    involved_in positive regulation of mitochondrial fission  
    involved_in positive regulation of mitochondrial fission  
    involved_in receptor internalization  
    involved_in receptor internalization  
    involved_in regulation of actin cytoskeleton organization  
    involved_in regulation of actin cytoskeleton organization  
    involved_in regulation of exocytosis  
    involved_in regulation of exocytosis PubMed 
    involved_in regulation of exocytosis  
    involved_in regulation of postsynaptic neurotransmitter receptor internalization  
    involved_in regulation of postsynaptic neurotransmitter receptor internalization  
    Component Evidence Code Pubs
    located_in Flemming body  
    located_in Schaffer collateral - CA1 synapse  
    is_active_in Schaffer collateral - CA1 synapse  
    located_in cell surface  
    located_in cell surface  
    located_in cleavage furrow  
    located_in cleavage furrow  
    located_in cytoplasmic vesicle membrane  
    located_in endocytic vesicle  
    colocalizes_with endocytic vesicle  
    located_in focal adhesion  
    located_in focal adhesion  
    located_in mitochondrion  
    located_in mitochondrion  
    located_in myelin sheath PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in synaptic membrane  
    is_active_in synaptic membrane  

    General protein information

    Preferred Names
    ras-related protein Ral-A
    Names
    RAS-like, family 1
    ral-A protein
    v-ral simian leukemia viral oncogene homolog A (ras related)
    NP_062364.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019491.5NP_062364.3  ras-related protein Ral-A

      See identical proteins and their annotated locations for NP_062364.3

      Status: PROVISIONAL

      Source sequence(s)
      CT009754
      Consensus CDS
      CCDS26255.1
      UniProtKB/Swiss-Prot
      P63321
      UniProtKB/TrEMBL
      Q9CXY0
      Related
      ENSMUSP00000009003.8, ENSMUST00000009003.9
      Conserved Domains (1) summary
      cd04139
      Location:15177
      RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      18055160..18118802 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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