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Tert telomerase reverse transcriptase [ Mus musculus (house mouse) ]

Gene ID: 21752, updated on 9-Dec-2024

Summary

Official Symbol
Tertprovided by MGI
Official Full Name
telomerase reverse transcriptaseprovided by MGI
Primary source
MGI:MGI:1202709
See related
Ensembl:ENSMUSG00000021611 AllianceGenome:MGI:1202709
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TR; TP2; TRT; EST2; TCS1
Summary
Enables telomerase RNA binding activity; telomerase activity; and transcription coactivator binding activity. Involved in positive regulation of Wnt signaling pathway; positive regulation of hair cycle; and positive regulation of stem cell proliferation. Acts upstream of or within positive regulation of D-glucose import. Located in mitochondrion and plasma membrane. Part of telomerase catalytic core complex. Is expressed in several structures, including early conceptus; genitourinary system; hemolymphoid system gland; sensory organ; and skin. Used to study prostate cancer. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant dyskeratosis congenita 2; carcinoma (multiple); gastrointestinal stromal tumor; leukemia (multiple); and melanoma (multiple). Orthologous to human TERT (telomerase reverse transcriptase). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in limb E14.5 (RPKM 4.7), adrenal adult (RPKM 3.6) and 25 other tissues See more
Orthologs
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Genomic context

See Tert in Genome Data Viewer
Location:
13 C1; 13 40.12 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (73775030..73797962)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (73626911..73649843)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Neighboring gene CLPTM1-like Neighboring gene Tert 5' regulatory region Neighboring gene STARR-seq mESC enhancer starr_34994 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:73778847-73779048 Neighboring gene STARR-seq mESC enhancer starr_34995 Neighboring gene STARR-seq mESC enhancer starr_34996 Neighboring gene solute carrier family 6 (neurotransmitter transporter), member 18 Neighboring gene solute carrier family 6 (neurotransmitter transporter), member 19 Neighboring gene solute carrier family 6 (neurotransmitter transporter), member 19, opposite strand

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC150124

Gene Ontology Provided by MGI

Items 1 - 25 of 28
Function Evidence Code Pubs
enables DNA binding  
enables DNA binding  
enables RNA binding PubMed 
enables RNA binding  
enables RNA-dependent RNA polymerase activity  
enables RNA-dependent RNA polymerase activity  
enables RNA-directed DNA polymerase activity  
enables identical protein binding  
enables metal ion binding  
enables protein binding PubMed 
enables protein homodimerization activity  
enables protein homodimerization activity  
enables protein-folding chaperone binding  
enables protein-folding chaperone binding  
enables tRNA binding  
enables tRNA binding  
enables telomerase RNA binding  
enables telomerase RNA binding PubMed 
enables telomerase RNA binding  
enables telomerase activity  
enables telomerase activity PubMed 
enables telomerase activity  
enables telomerase activity PubMed 
enables telomeric DNA binding  
enables template-free RNA nucleotidyltransferase  
enables template-free RNA nucleotidyltransferase  
enables transcription coactivator binding PubMed 
enables transcription coactivator binding  
Items 1 - 25 of 28
Items 1 - 25 of 58
Process Evidence Code Pubs
involved_in DNA biosynthetic process  
involved_in DNA strand elongation  
involved_in DNA strand elongation  
involved_in RNA-templated DNA biosynthetic process  
involved_in RNA-templated transcription  
involved_in cellular response to hypoxia  
involved_in cellular response to hypoxia  
involved_in establishment of protein localization to telomere  
involved_in establishment of protein localization to telomere  
involved_in mitochondrion organization  
involved_in mitochondrion organization  
involved_in negative regulation of apoptotic process  
involved_in negative regulation of cellular senescence  
involved_in negative regulation of cellular senescence  
involved_in negative regulation of endothelial cell apoptotic process  
involved_in negative regulation of endothelial cell apoptotic process  
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
involved_in negative regulation of gene expression  
involved_in negative regulation of glial cell proliferation  
involved_in negative regulation of neuron apoptotic process  
involved_in negative regulation of neuron apoptotic process  
acts_upstream_of_or_within positive regulation of D-glucose import PubMed 
involved_in positive regulation of G1/S transition of mitotic cell cycle  
involved_in positive regulation of G1/S transition of mitotic cell cycle  
involved_in positive regulation of Wnt signaling pathway PubMed 
involved_in positive regulation of Wnt signaling pathway  
involved_in positive regulation of angiogenesis  
involved_in positive regulation of angiogenesis  
involved_in positive regulation of hair cycle PubMed 
involved_in positive regulation of miRNA transcription  
involved_in positive regulation of miRNA transcription  
involved_in positive regulation of nitric-oxide synthase activity  
involved_in positive regulation of protein binding  
involved_in positive regulation of protein localization to nucleolus  
involved_in positive regulation of protein localization to nucleolus  
involved_in positive regulation of stem cell proliferation PubMed 
involved_in positive regulation of transdifferentiation  
involved_in positive regulation of transdifferentiation  
involved_in positive regulation of vascular associated smooth muscle cell migration  
involved_in positive regulation of vascular associated smooth muscle cell migration  
involved_in positive regulation of vascular associated smooth muscle cell proliferation  
involved_in positive regulation of vascular associated smooth muscle cell proliferation  
involved_in regulation of protein stability  
involved_in regulation of protein stability  
involved_in replicative senescence  
involved_in replicative senescence  
involved_in response to cadmium ion  
involved_in siRNA processing  
involved_in siRNA processing  
involved_in siRNA transcription  
involved_in siRNA transcription  
involved_in telomere maintenance via recombination PubMed 
involved_in telomere maintenance via telomerase  
involved_in telomere maintenance via telomerase  
involved_in telomere maintenance via telomerase  
involved_in telomere maintenance via telomerase PubMed 
involved_in telomere maintenance via telomerase PubMed 
Items 1 - 25 of 58
Items 1 - 20 of 28
Component Evidence Code Pubs
located_in PML body  
colocalizes_with PML body  
part_of RNA-directed RNA polymerase complex  
part_of TERT-RMRP complex  
part_of TERT-RMRP complex  
located_in chromosome, telomeric region  
located_in chromosome, telomeric region  
located_in cytoplasm PubMed 
located_in cytosol  
located_in cytosol  
located_in mitochondrial nucleoid  
located_in mitochondrial nucleoid  
located_in mitochondrion PubMed 
located_in mitochondrion  
located_in nuclear speck  
located_in nuclear speck  
located_in nucleolus  
located_in nucleolus  
located_in nucleoplasm  
located_in nucleus  
located_in plasma membrane PubMed 
part_of telomerase catalytic core complex  
part_of telomerase catalytic core complex PubMed 
part_of telomerase catalytic core complex  
part_of telomerase catalytic core complex PubMed 
part_of telomerase holoenzyme complex  
part_of telomerase holoenzyme complex  
part_of telomerase holoenzyme complex PubMed 
Items 1 - 20 of 28

General protein information

Preferred Names
telomerase reverse transcriptase
Names
telomerase catalytic subunit
telomerase reverse transcriptase beta
NP_001349316.1
NP_001349317.1
NP_033380.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362387.1NP_001349316.1  telomerase reverse transcriptase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158359, AK133783, BC082327
    Conserved Domains (2) summary
    smart00975
    Location:57191
    Telomerase_RBD; Telomerase ribonucleoprotein complex - RNA binding domain
    cd01648
    Location:422536
    TERT; TERT: Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as ...
  2. NM_001362388.1NP_001349317.1  telomerase reverse transcriptase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK133783, BC082327, BC127068
    UniProtKB/TrEMBL
    A0JNY9
    Conserved Domains (2) summary
    cd01648
    Location:277391
    TERT; TERT: Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as ...
    cl13446
    Location:146
    Telomerase_RBD; Telomerase ribonucleoprotein complex - RNA binding domain
  3. NM_009354.2NP_033380.1  telomerase reverse transcriptase isoform 1

    See identical proteins and their annotated locations for NP_033380.1

    Status: VALIDATED

    Source sequence(s)
    AF051911, AK133783, BC082327
    Consensus CDS
    CCDS26633.1
    UniProtKB/Swiss-Prot
    O35432, O70372, Q9JK99
    Related
    ENSMUSP00000022104.8, ENSMUST00000022104.9
    Conserved Domains (2) summary
    smart00975
    Location:450584
    Telomerase_RBD; Telomerase ribonucleoprotein complex - RNA binding domain
    cd01648
    Location:815929
    TERT; TERT: Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    73775030..73797962
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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