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    Polr1D RNA polymerase I and III subunit D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35196, updated on 9-Dec-2024

    Summary

    Official Symbol
    Polr1Dprovided by FlyBase
    Official Full Name
    RNA polymerase I and III subunit Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086447
    Locus tag
    Dmel_CG10685
    See related
    AllianceGenome:FB:FBgn0086447
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AC19; Cg; CG10685; Dmel\CG10685; l(2)37Cg; RPC19
    Summary
    Predicted to enable DNA binding activity and protein dimerization activity. Predicted to contribute to RNA polymerase I activity and RNA polymerase III activity. Predicted to be involved in tRNA transcription by RNA polymerase III and transcription elongation by RNA polymerase I. Predicted to be part of RNA polymerase I complex and RNA polymerase III complex. Used to study Treacher Collins syndrome 2. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 2. Orthologous to human POLR1D (RNA polymerase I and III subunit D). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Polr1D in Genome Data Viewer
    Location:
    37C1-37C1; 2-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19133023..19135233, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19133023..19135233, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene lethal (2) 37Cd Neighboring gene Dynactin 6, p27 subunit Neighboring gene Asparaginyl-tRNA synthetase Neighboring gene brain tumor Neighboring gene long non-coding RNA:CR44977 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding  
    enables DNA-directed 5'-3' RNA polymerase activity  
    contributes_to DNA-directed 5'-3' RNA polymerase activity  
    contributes_to RNA polymerase I activity  
    contributes_to RNA polymerase I activity  
    contributes_to RNA polymerase III activity  
    contributes_to RNA polymerase III activity  
    enables protein dimerization activity  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription  
    involved_in tRNA transcription by RNA polymerase III  
    involved_in transcription by RNA polymerase I  
    involved_in transcription by RNA polymerase III  
    involved_in transcription elongation by RNA polymerase I  
    Component Evidence Code Pubs
    part_of RNA polymerase I complex  
    part_of RNA polymerase I complex  
    part_of RNA polymerase III complex  
    part_of RNA polymerase III complex  

    General protein information

    Preferred Names
    RNA polymerase I and III subunit D
    Names
    CG10685-PA
    CG10685-PC
    CG10685-PD
    Polr1D-PA
    Polr1D-PC
    Polr1D-PD
    lethal (2) 37Cg

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19133023..19135233 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273633.1NP_001260562.1  RNA polymerase I and III subunit D, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260562.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5SHL6, M9PG66
      Conserved Domains (2) summary
      cd07029
      Location:21102
      RNAP_I_III_AC19; AC19 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III
      pfam01193
      Location:3064
      RNA_pol_L; RNA polymerase Rpb3/Rpb11 dimerization domain
    2. NM_001273634.1NP_001260563.1  RNA polymerase I and III subunit D, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260563.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5SHL6, M9PBD6
      Conserved Domains (2) summary
      cd07029
      Location:37118
      RNAP_I_III_AC19; AC19 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III
      pfam01193
      Location:4680
      RNA_pol_L; RNA polymerase Rpb3/Rpb11 dimerization domain
    3. NM_136106.2NP_609950.1  RNA polymerase I and III subunit D, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609950.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0IGY9, Q9VIZ0
      UniProtKB/TrEMBL
      A0A1B2AKR4
      Related
      FBpp0080704
      Conserved Domains (2) summary
      cd07029
      Location:1091
      RNAP_I_III_AC19; AC19 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III
      pfam01193
      Location:1953
      RNA_pol_L; RNA polymerase Rpb3/Rpb11 dimerization domain
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