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Jam2 junction adhesion molecule 2 [ Mus musculus (house mouse) ]

Gene ID: 67374, updated on 17-Dec-2024

Summary

Official Symbol
Jam2provided by MGI
Official Full Name
junction adhesion molecule 2provided by MGI
Primary source
MGI:MGI:1933820
See related
Ensembl:ENSMUSG00000053062 AllianceGenome:MGI:1933820
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
JAM-2; JAM-B; Jcam2; VE-JAM; 1110002N23Rik; 2410030G21Rik; 2410167M24Rik
Summary
Predicted to enable integrin binding activity. Involved in several processes, including hematopoietic stem cell migration to bone marrow; leukocyte tethering or rolling; and negative regulation of myelination. Acts upstream of or within negative regulation of cell adhesion. Located in cell surface; somatodendritic compartment; and tight junction. Is expressed in several structures, including alimentary system; brain; cardiovascular system; eye; and genitourinary system. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human JAM2 (junctional adhesion molecule 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in heart adult (RPKM 20.4), frontal lobe adult (RPKM 12.0) and 21 other tissues See more
Orthologs
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Genomic context

See Jam2 in Genome Data Viewer
Location:
16 C3.3; 16 46.92 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (84571011..84623268)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (84774123..84826380)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26153 Neighboring gene STARR-seq mESC enhancer starr_41365 Neighboring gene predicted gene, 32202 Neighboring gene STARR-seq mESC enhancer starr_41367 Neighboring gene STARR-positive B cell enhancer ABC_E5555 Neighboring gene predicted gene, 46557 Neighboring gene ATP synthase peripheral stalk subunit F6 Neighboring gene GA repeat binding protein, alpha Neighboring gene STARR-seq mESC enhancer starr_41374 Neighboring gene STARR-seq mESC enhancer starr_41375 Neighboring gene predicted gene 10791 Neighboring gene amyloid beta precursor protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (6)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables integrin binding  
enables integrin binding  
enables protein binding PubMed 
Component Evidence Code Pubs
NOT located_in axon PubMed 
located_in bicellular tight junction  
is_active_in cell surface  
located_in cell surface PubMed 
located_in cell surface  
located_in cell-cell contact zone  
is_active_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  
part_of protein complex involved in cell adhesion  
part_of protein complex involved in cell adhesion  
part_of protein complex involved in cell adhesion  
located_in somatodendritic compartment PubMed 
is_active_in tight junction  
located_in tight junction PubMed 

General protein information

Preferred Names
junctional adhesion molecule B
Names
junction adhesion molecule B
junction cell adhesion molecule 2
junctional adhesion molecule 2
vascular endothelial junction-associated molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023844.5NP_076333.3  junctional adhesion molecule B precursor

    See identical proteins and their annotated locations for NP_076333.3

    Status: VALIDATED

    Source sequence(s)
    AC164162, BC028778
    Consensus CDS
    CCDS37381.1
    UniProtKB/Swiss-Prot
    A6X955, Q8C5K9, Q8CE95, Q9JI59
    UniProtKB/TrEMBL
    A0A338P721
    Related
    ENSMUSP00000109833.2, ENSMUST00000114195.8
    Conserved Domains (3) summary
    cd00096
    Location:47113
    Ig; Immunoglobulin domain
    smart00408
    Location:149221
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:143221
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    84571011..84623268
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523075.5XP_006523138.1  junctional adhesion molecule B isoform X1

    UniProtKB/TrEMBL
    A0A338P721
    Related
    ENSMUSP00000156235.2, ENSMUST00000231910.2
    Conserved Domains (2) summary
    smart00408
    Location:190262
    IGc2; Immunoglobulin C-2 Type
    cl11960
    Location:76151
    Ig; Immunoglobulin domain
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