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GOSR1 golgi SNAP receptor complex member 1 [ Homo sapiens (human) ]

Gene ID: 9527, updated on 10-Dec-2024

Summary

Official Symbol
GOSR1provided by HGNC
Official Full Name
golgi SNAP receptor complex member 1provided by HGNC
Primary source
HGNC:HGNC:4430
See related
Ensembl:ENSG00000108587 MIM:604026; AllianceGenome:HGNC:4430
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P28; GS28; GOS28; GOLIM2; GOS-28; GOS28/P28
Summary
This gene encodes a trafficking membrane protein which transports proteins among the endoplasmic reticulum and the Golgi and between Golgi compartments. This protein is considered an essential component of the Golgi SNAP receptor (SNARE) complex. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 7.3), kidney (RPKM 5.6) and 25 other tissues See more
Orthologs
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Genomic context

See GOSR1 in Genome Data Viewer
Location:
17q11.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (30477408..30527592)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (31422038..31472230)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (28804426..28854610)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11994 Neighboring gene RNA, U6 small nuclear 990, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11995 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11997 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:28705846-28706773 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:28715045-28715730 Neighboring gene Sharpr-MPRA regulatory region 2970 Neighboring gene carboxypeptidase D Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:28732022-28732693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11999 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:28863435-28863984 Neighboring gene arachidonate 12-lipoxygenase pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:28868427-28868928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:28878036-28878566 Neighboring gene TBC1 domain family member 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SNAP receptor activity  
enables SNAP receptor activity PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus PubMed 
is_active_in Golgi medial cisterna  
is_active_in Golgi membrane  
located_in Golgi membrane PubMed 
located_in Golgi membrane  
part_of SNARE complex  
part_of SNARE complex PubMed 
located_in cis-Golgi network  
located_in cytosol  
located_in membrane PubMed 
located_in transport vesicle  

General protein information

Preferred Names
Golgi SNAP receptor complex member 1
Names
28 kDa Golgi SNARE protein
28 kDa cis-Golgi SNARE p28
Golgi SNARE 28 kDa
cis-golgi SNARE
golgi integral membrane protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007024.2NP_001007025.1  Golgi SNAP receptor complex member 1 isoform 3

    See identical proteins and their annotated locations for NP_001007025.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an additional segment in one exon and lacks a small segment in another exon in the 5' region, as compared to variant 1. It uses a downstream AUG start codon, and the encoded isoform 3 thus has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC011840, AF047438, AK000606, AK074298, BC040072, BC040471, BG654545, CB054624
    Consensus CDS
    CCDS45644.1
    UniProtKB/Swiss-Prot
    O95249
    Related
    ENSP00000462638.1, ENST00000467337.6
    Conserved Domains (1) summary
    cd15864
    Location:95160
    SNARE_GS28; SNARE motif of GS28
  2. NM_001007025.2NP_001007026.1  Golgi SNAP receptor complex member 1 isoform 2

    See identical proteins and their annotated locations for NP_001007026.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame small segment of 6 nts in the 5' coding region, as compared to variant 1. The encoded isoform 2 thus lacks internal 2 aa, as compared to isoform 1.
    Source sequence(s)
    AC011840, AK000606, AK074298, BC040072, BC040471, BE785872, CB054624
    Consensus CDS
    CCDS45643.1
    UniProtKB/TrEMBL
    A8K5R6, E9PCW1
    Related
    ENSP00000414441.2, ENST00000451249.7
    Conserved Domains (1) summary
    cd15864
    Location:158223
    SNARE_GS28; SNARE motif of GS28
  3. NM_004871.3NP_004862.1  Golgi SNAP receptor complex member 1 isoform 1

    See identical proteins and their annotated locations for NP_004862.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC011840, AK000606, AK074298, BC040072, BC040471, CB054624
    Consensus CDS
    CCDS11258.1
    UniProtKB/Swiss-Prot
    J3KST5, O75392, O95249
    UniProtKB/TrEMBL
    A8K5R6
    Related
    ENSP00000225724.5, ENST00000225724.9
    Conserved Domains (1) summary
    cd15864
    Location:160225
    SNARE_GS28; SNARE motif of GS28

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    30477408..30527592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258070.6XP_005258127.1  Golgi SNAP receptor complex member 1 isoform X1

    UniProtKB/TrEMBL
    A8K5R6
    Conserved Domains (1) summary
    cd15864
    Location:210275
    SNARE_GS28; SNARE motif of GS28
  2. XM_017025374.3XP_016880863.1  Golgi SNAP receptor complex member 1 isoform X3

    UniProtKB/TrEMBL
    A8K5R6
  3. XM_005258071.6XP_005258128.1  Golgi SNAP receptor complex member 1 isoform X2

    UniProtKB/TrEMBL
    A8K5R6
    Conserved Domains (1) summary
    cd15864
    Location:208273
    SNARE_GS28; SNARE motif of GS28
  4. XM_047437109.1XP_047293065.1  Golgi SNAP receptor complex member 1 isoform X4

    UniProtKB/TrEMBL
    A8K5R6
  5. XM_047437111.1XP_047293067.1  Golgi SNAP receptor complex member 1 isoform X7

  6. XM_047437110.1XP_047293066.1  Golgi SNAP receptor complex member 1 isoform X7

  7. XM_005258072.4XP_005258129.1  Golgi SNAP receptor complex member 1 isoform X7

    See identical proteins and their annotated locations for XP_005258129.1

    UniProtKB/Swiss-Prot
    O95249
    Conserved Domains (1) summary
    cd15864
    Location:95160
    SNARE_GS28; SNARE motif of GS28
  8. XM_017025375.3XP_016880864.1  Golgi SNAP receptor complex member 1 isoform X5

    UniProtKB/TrEMBL
    K7EJC8
    Related
    ENSP00000465115.1, ENST00000581721.5
  9. XM_017025376.3XP_016880865.1  Golgi SNAP receptor complex member 1 isoform X6

    UniProtKB/TrEMBL
    K7EJC8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    31422038..31472230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317886.1XP_054173861.1  Golgi SNAP receptor complex member 1 isoform X7

  2. XM_054317883.1XP_054173858.1  Golgi SNAP receptor complex member 1 isoform X5

    UniProtKB/TrEMBL
    K7EJC8
  3. XM_054317884.1XP_054173859.1  Golgi SNAP receptor complex member 1 isoform X6

    UniProtKB/TrEMBL
    K7EJC8
  4. XM_054317879.1XP_054173854.1  Golgi SNAP receptor complex member 1 isoform X1

    UniProtKB/TrEMBL
    A8K5R6
  5. XM_054317880.1XP_054173855.1  Golgi SNAP receptor complex member 1 isoform X2

    UniProtKB/TrEMBL
    A8K5R6
  6. XM_054317881.1XP_054173856.1  Golgi SNAP receptor complex member 1 isoform X3

    UniProtKB/TrEMBL
    A8K5R6
  7. XM_054317887.1XP_054173862.1  Golgi SNAP receptor complex member 1 isoform X7

  8. XM_054317885.1XP_054173860.1  Golgi SNAP receptor complex member 1 isoform X7

  9. XM_054317882.1XP_054173857.1  Golgi SNAP receptor complex member 1 isoform X4

    UniProtKB/TrEMBL
    A8K5R6
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