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Trmt1l tRNA methyltransferase 1 like [ Mus musculus (house mouse) ]

Gene ID: 98685, updated on 9-Dec-2024

Summary

Official Symbol
Trmt1lprovided by MGI
Official Full Name
tRNA methyltransferase 1 likeprovided by MGI
Primary source
MGI:MGI:1916185
See related
Ensembl:ENSMUSG00000053286 AllianceGenome:MGI:1916185
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trm1l; C1orf25; Trm1-like; 1190005F20Rik
Summary
Predicted to enable metal ion binding activity; tRNA (guanine) methyltransferase activity; and tRNA binding activity. Acts upstream of or within adult locomotory behavior. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; hemolymphoid system gland; male reproductive gland or organ; nervous system; and respiratory system. Orthologous to human TRMT1L (tRNA methyltransferase 1 like). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.6), CNS E14 (RPKM 10.5) and 28 other tissues See more
Orthologs
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Genomic context

See Trmt1l in Genome Data Viewer
Location:
1 G1; 1 64.12 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (151304293..151333934)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (151428542..151458183)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10138 Neighboring gene STARR-positive B cell enhancer mm9_chr1:153191350-153191651 Neighboring gene STARR-positive B cell enhancer ABC_E3313 Neighboring gene influenza virus NS1A binding protein Neighboring gene SWT1 RNA endoribonuclease homolog (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E994 Neighboring gene STARR-positive B cell enhancer ABC_E5817 Neighboring gene STARR-seq mESC enhancer starr_02618 Neighboring gene microRNA 7682 Neighboring gene STARR-seq mESC enhancer starr_02619 Neighboring gene ring finger protein 2 Neighboring gene cytochrome c oxidase subunit 7B, mitochondrial pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1)  1 citation

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC70241

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding  
enables tRNA (guanine) methyltransferase activity  
enables tRNA binding  
Process Evidence Code Pubs
acts_upstream_of_or_within adult behavior PubMed 
acts_upstream_of_or_within adult locomotory behavior PubMed 
involved_in methylation  
involved_in tRNA N2-guanine methylation  
involved_in tRNA processing  
Component Evidence Code Pubs
is_active_in nucleus  

General protein information

Preferred Names
TRMT1-like protein
NP_001344498.1
NP_001344499.1
NP_081152.2
XP_030099757.1
XP_036010624.1
XP_036010625.1
XP_036010628.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357569.1NP_001344498.1  TRMT1-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC165946
    UniProtKB/Swiss-Prot
    A2RSY6, Q0VGB9, Q3UFG1, Q3UKB0, Q8C2S4, Q8CI50, Q8R203, Q9CT68
    Conserved Domains (2) summary
    cl17173
    Location:225666
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cl22851
    Location:157202
    PHD_SF; PHD finger superfamily
  2. NM_001357570.1NP_001344499.1  TRMT1-like protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AI853808, AK148524, BC064024
    Conserved Domains (1) summary
    cl17173
    Location:16419
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  3. NM_026876.4NP_081152.2  TRMT1-like protein isoform 1

    See identical proteins and their annotated locations for NP_081152.2

    Status: VALIDATED

    Source sequence(s)
    AI853808, AK148524, BC110425
    Consensus CDS
    CCDS15361.1
    UniProtKB/Swiss-Prot
    A2RSY6, Q0VGB9, Q3UFG1, Q3UKB0, Q8C2S4, Q8CI50, Q8R203, Q9CT68
    UniProtKB/TrEMBL
    A0A0R4J0U8
    Related
    ENSMUSP00000068309.6, ENSMUST00000065625.12
    Conserved Domains (2) summary
    cl17173
    Location:225687
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cl22851
    Location:157202
    PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    151304293..151333934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154732.1XP_036010625.1  TRMT1-like protein isoform X3

    Conserved Domains (1) summary
    cl17173
    Location:225425
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. XM_036154731.1XP_036010624.1  TRMT1-like protein isoform X1

    Conserved Domains (1) summary
    cl17173
    Location:72534
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  3. XM_030243897.2XP_030099757.1  TRMT1-like protein isoform X2

    Conserved Domains (1) summary
    cl17173
    Location:16419
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  4. XM_036154735.1XP_036010628.1  TRMT1-like protein isoform X4

    Conserved Domains (1) summary
    cl17173
    Location:16398
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
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