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SCTR secretin receptor [ Homo sapiens (human) ]

Gene ID: 6344, updated on 27-Dec-2024

Summary

Official Symbol
SCTRprovided by HGNC
Official Full Name
secretin receptorprovided by HGNC
Primary source
HGNC:HGNC:10608
See related
Ensembl:ENSG00000080293 MIM:182098; AllianceGenome:HGNC:10608
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SR
Summary
The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its receptor are suggested to be involved in pancreatic cancer and autism. [provided by RefSeq, Jul 2008]
Expression
Biased expression in duodenum (RPKM 6.3), pancreas (RPKM 4.3) and 5 other tissues See more
Orthologs
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Genomic context

See SCTR in Genome Data Viewer
Location:
2q14.2
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (119439843..119524483, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (119873301..119957984, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (120197419..120282059, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene chromosome 2 open reading frame 76 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16450 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16451 Neighboring gene diazepam binding inhibitor, acyl-CoA binding protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11905 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120189865-120190371 Neighboring gene transmembrane protein 37 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120231245-120231796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120232347-120232897 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120238515-120239026 Neighboring gene VISTA enhancer hs1941 Neighboring gene SCTR antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11906 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16452 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11907 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11908 Neighboring gene cilia and flagella associated protein 221 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11909 Neighboring gene MPRA-validated peak3833 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11910 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11911 Neighboring gene transmembrane protein 177 Neighboring gene ribosomal protein L17 pseudogene 15

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity  
enables peptide hormone binding  
enables peptide hormone binding PubMed 
enables secretin receptor activity  
enables secretin receptor activity PubMed 
Component Evidence Code Pubs
located_in cytoplasmic microtubule PubMed 
is_active_in plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
secretin receptor
Names
pancreatic secretin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029904.1 RefSeqGene

    Range
    4970..89610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002980.3NP_002971.2  secretin receptor precursor

    See identical proteins and their annotated locations for NP_002971.2

    Status: REVIEWED

    Source sequence(s)
    AC013275
    Consensus CDS
    CCDS2127.1
    UniProtKB/Swiss-Prot
    P47872, Q12961, Q13213, Q53T00
    UniProtKB/TrEMBL
    B2RBF3, Q8IV17
    Related
    ENSP00000019103.6, ENST00000019103.8
    Conserved Domains (2) summary
    pfam00002
    Location:139384
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:64126
    HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    119439843..119524483 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511621.3XP_011509923.1  secretin receptor isoform X3

    UniProtKB/TrEMBL
    B2RBF3, Q8IV17
    Conserved Domains (2) summary
    pfam00002
    Location:139389
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:64126
    HRM; Hormone receptor domain
  2. XM_047445401.1XP_047301357.1  secretin receptor isoform X5

    UniProtKB/TrEMBL
    B2RBF3, Q8IV17
  3. XM_047445400.1XP_047301356.1  secretin receptor isoform X2

    UniProtKB/TrEMBL
    B2RBF3, Q8IV17
  4. XM_047445399.1XP_047301355.1  secretin receptor isoform X1

    UniProtKB/TrEMBL
    B2RBF3, Q8IV17
  5. XM_017004670.2XP_016860159.2  secretin receptor isoform X4

    UniProtKB/TrEMBL
    B2RBF3, Q8IV17
  6. XM_047445403.1XP_047301359.1  secretin receptor isoform X7

  7. XM_047445402.1XP_047301358.1  secretin receptor isoform X6

  8. XM_047445404.1XP_047301360.1  secretin receptor isoform X8

RNA

  1. XR_922984.3 RNA Sequence

  2. XR_001738889.2 RNA Sequence

  3. XR_007079571.1 RNA Sequence

  4. XR_001738888.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    119873301..119957984 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343329.1XP_054199304.1  secretin receptor isoform X3

    UniProtKB/TrEMBL
    B2RBF3, Q8IV17
  2. XM_054343331.1XP_054199306.1  secretin receptor isoform X5

    UniProtKB/TrEMBL
    B2RBF3, Q8IV17
  3. XM_054343328.1XP_054199303.1  secretin receptor isoform X2

    UniProtKB/TrEMBL
    B2RBF3, Q8IV17
  4. XM_054343327.1XP_054199302.1  secretin receptor isoform X1

    UniProtKB/TrEMBL
    B2RBF3, Q8IV17
  5. XM_054343330.1XP_054199305.1  secretin receptor isoform X4

    UniProtKB/TrEMBL
    B2RBF3, Q8IV17
  6. XM_054343333.1XP_054199308.1  secretin receptor isoform X7

  7. XM_054343332.1XP_054199307.1  secretin receptor isoform X6

  8. XM_054343334.1XP_054199309.1  secretin receptor isoform X8

RNA

  1. XR_008486482.1 RNA Sequence

  2. XR_008486484.1 RNA Sequence

  3. XR_008486481.1 RNA Sequence

  4. XR_008486483.1 RNA Sequence

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