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    fbp fructose-1,6-bisphosphatase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35265, updated on 27-Dec-2024

    Summary

    Official Symbol
    fbpprovided by FlyBase
    Official Full Name
    fructose-1,6-bisphosphataseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032820
    Locus tag
    Dmel_CG31692
    See related
    AllianceGenome:FB:FBgn0032820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10611; CG31692; Dmel\CG31692; Fbp; FbPase
    Summary
    Predicted to enable fructose 1,6-bisphosphate 1-phosphatase activity. Predicted to be involved in fructose 1,6-bisphosphate metabolic process; fructose 6-phosphate metabolic process; and hexose metabolic process. Predicted to be active in cytosol. Is expressed in several structures, including adult head; adult heart; embryonic/larval crystal cell; larval muscle cell; and somatic trunk mesoderm derivative. Human ortholog(s) of this gene implicated in fructose-1,6-bisphosphatase deficiency. Orthologous to human FBP1 (fructose-bisphosphatase 1) and FBP2 (fructose-bisphosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See fbp in Genome Data Viewer
    Location:
    38A2-38A3; 2-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19761587..19764136, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19761587..19764136, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Dihydrouridine synthase 3 Neighboring gene brain-specific homeobox Neighboring gene Cd GTPase activating protein-related

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    mobile_element

    • Loc: c19763048-19762862 mobile_element_type = transposon:pogo{}421

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables fructose 1,6-bisphosphate 1-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fructose 1,6-bisphosphate 1-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables fructose 1,6-bisphosphate 1-phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fructose 1,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fructose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fructose 6-phosphate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fructose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in gluconeogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    fructose-1,6-bisphosphatase
    Names
    CG31692-PA
    CG31692-PC
    CG31692-PD
    CG31692-PF
    fbp-PA
    fbp-PC
    fbp-PD
    fbp-PF
    NP_001286090.1
    NP_001286091.1
    NP_610001.1
    NP_724223.4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19761587..19764136 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299161.1NP_001286090.1  fructose-1,6-bisphosphatase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286090.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JES1
      Conserved Domains (1) summary
      cd00354
      Location:7321
      FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...
    2. NM_136157.3NP_610001.1  fructose-1,6-bisphosphatase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610001.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KT33, Q9VIS3
      Related
      FBpp0080853
      Conserved Domains (1) summary
      cd00354
      Location:19333
      FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...
    3. NM_001299162.1NP_001286091.1  fructose-1,6-bisphosphatase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286091.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JES1
      Conserved Domains (1) summary
      cd00354
      Location:7321
      FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...
    4. NM_165314.2NP_724223.4  fructose-1,6-bisphosphatase, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0U1RVK6, C6SV43
      Conserved Domains (1) summary
      cd00354
      Location:28342
      FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...