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    Asah2 N-acylsphingosine amidohydrolase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114104, updated on 9-Dec-2024

    Summary

    Official Symbol
    Asah2provided by RGD
    Official Full Name
    N-acylsphingosine amidohydrolase 2provided by RGD
    Primary source
    RGD:69410
    See related
    EnsemblRapid:ENSRNOG00000012196 AllianceGenome:RGD:69410
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables N-acylsphingosine amidohydrolase activity. Involved in ceramide biosynthetic process; ceramide catabolic process; and sphingosine biosynthetic process. Located in several cellular components, including extracellular space; membrane raft; and mitochondrion. Orthologous to human ASAH2 (N-acylsphingosine amidohydrolase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 32.8), Adrenal (RPKM 25.4) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Asah2 in Genome Data Viewer
    Location:
    1q52
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (239278994..239386598, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (229865662..229973253, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (250557042..250665083, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene protein kinase cGMP-dependent 1 Neighboring gene uncharacterized LOC120097454 Neighboring gene APOBEC1 complementation factor Neighboring gene sphingomyelin synthase 1 Neighboring gene small nucleolar RNA SNORA48

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acylsphingosine amidohydrolase activity  
    enables N-acylsphingosine amidohydrolase activity PubMed 
    enables N-acylsphingosine amidohydrolase activity  
    enables N-acylsphingosine amidohydrolase activity  
    enables N-acylsphingosine amidohydrolase activity  
    enables calcium ion binding  
    enables calcium ion binding  
    enables zinc ion binding  
    enables zinc ion binding  
    Process Evidence Code Pubs
    involved_in apoptotic process  
    involved_in cellular response to cytokine stimulus  
    involved_in ceramide biosynthetic process PubMed 
    involved_in ceramide biosynthetic process  
    involved_in ceramide catabolic process  
    involved_in ceramide catabolic process PubMed 
    involved_in ceramide catabolic process  
    involved_in ceramide catabolic process  
    involved_in ceramide metabolic process  
    involved_in ceramide metabolic process  
    involved_in lipid digestion  
    involved_in lipid digestion  
    involved_in long-chain fatty acid biosynthetic process  
    involved_in negative regulation of apoptotic signaling pathway  
    involved_in negative regulation of apoptotic signaling pathway  
    involved_in regulation of mitotic cell cycle  
    involved_in regulation of mitotic cell cycle  
    involved_in sphingosine biosynthetic process  
    involved_in sphingosine biosynthetic process PubMed 
    involved_in sphingosine biosynthetic process  
    involved_in sphingosine metabolic process  
    involved_in sphingosine metabolic process  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in Golgi membrane  
    located_in caveola  
    located_in caveola  
    located_in extracellular exosome  
    located_in extracellular exosome  
    is_active_in extracellular region  
    located_in extracellular space PubMed 
    located_in extracellular space  
    located_in membrane  
    located_in membrane  
    located_in membrane raft PubMed 
    NOT located_in mitochondrion PubMed 
    located_in mitochondrion PubMed 
    located_in mitochondrion  
    located_in plasma membrane PubMed 
    located_in plasma membrane  

    General protein information

    Preferred Names
    neutral ceramidase
    Names
    N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
    NCDase
    acylsphingosine deacylase 2
    neutral/alkaline ceramidase
    NP_446098.1
    XP_006231325.1
    XP_006231332.1
    XP_008758542.1
    XP_017444136.1
    XP_017444137.1
    XP_017444139.1
    XP_038962801.1
    XP_038962806.1
    XP_038962807.1
    XP_038962839.1
    XP_038962916.1
    XP_038962949.1
    XP_038962978.1
    XP_038963012.1
    XP_038963044.1
    XP_038963081.1
    XP_063118252.1
    XP_063118305.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053646.2NP_446098.1  neutral ceramidase

      See identical proteins and their annotated locations for NP_446098.1

      Status: VALIDATED

      Source sequence(s)
      AB057433, JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q91XT9
      UniProtKB/TrEMBL
      A0A8L2Q853, A6I102
      Related
      ENSRNOP00000073116.2, ENSRNOT00000077135.3
      Conserved Domains (2) summary
      pfam04734
      Location:83589
      Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
      pfam17048
      Location:591758
      Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      239278994..239386598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107021.2XP_038962949.1  neutral ceramidase isoform X1

      UniProtKB/Swiss-Prot
      Q91XT9
      UniProtKB/TrEMBL
      A0A8L2Q853, A6I102
      Conserved Domains (2) summary
      pfam04734
      Location:83589
      Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
      pfam17048
      Location:591758
      Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
    2. XM_039106988.2XP_038962916.1  neutral ceramidase isoform X1

      UniProtKB/Swiss-Prot
      Q91XT9
      UniProtKB/TrEMBL
      A0A8L2Q853, A6I102
      Conserved Domains (2) summary
      pfam04734
      Location:83589
      Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
      pfam17048
      Location:591758
      Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
    3. XM_006231263.3XP_006231325.1  neutral ceramidase isoform X1

      See identical proteins and their annotated locations for XP_006231325.1

      UniProtKB/Swiss-Prot
      Q91XT9
      UniProtKB/TrEMBL
      A0A8L2Q853, A6I102
      Conserved Domains (2) summary
      pfam04734
      Location:83589
      Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
      pfam17048
      Location:591758
      Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
    4. XM_006231270.3XP_006231332.1  neutral ceramidase isoform X1

      See identical proteins and their annotated locations for XP_006231332.1

      UniProtKB/Swiss-Prot
      Q91XT9
      UniProtKB/TrEMBL
      A0A8L2Q853, A6I102
      Conserved Domains (2) summary
      pfam04734
      Location:83589
      Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
      pfam17048
      Location:591758
      Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
    5. XM_063262182.1XP_063118252.1  neutral ceramidase isoform X1

      UniProtKB/Swiss-Prot
      Q91XT9
      UniProtKB/TrEMBL
      A0A8L2Q853, A6I102
    6. XM_008760320.4XP_008758542.1  neutral ceramidase isoform X1

      See identical proteins and their annotated locations for XP_008758542.1

      UniProtKB/Swiss-Prot
      Q91XT9
      UniProtKB/TrEMBL
      A0A8L2Q853, A6I102
      Conserved Domains (2) summary
      pfam04734
      Location:83589
      Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
      pfam17048
      Location:591758
      Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
    7. XM_039107153.2XP_038963081.1  neutral ceramidase isoform X1

      UniProtKB/Swiss-Prot
      Q91XT9
      UniProtKB/TrEMBL
      A0A8L2Q853, A6I102
      Conserved Domains (2) summary
      pfam04734
      Location:83589
      Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
      pfam17048
      Location:591758
      Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
    8. XM_039106879.2XP_038962807.1  neutral ceramidase isoform X1

      UniProtKB/Swiss-Prot
      Q91XT9
      UniProtKB/TrEMBL
      A0A8L2Q853, A6I102
      Conserved Domains (2) summary
      pfam04734
      Location:83589
      Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
      pfam17048
      Location:591758
      Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
    9. XM_039107084.2XP_038963012.1  neutral ceramidase isoform X1

      UniProtKB/Swiss-Prot
      Q91XT9
      UniProtKB/TrEMBL
      A0A8L2Q853, A6I102
      Conserved Domains (2) summary
      pfam04734
      Location:83589
      Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
      pfam17048
      Location:591758
      Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
    10. XM_063262235.1XP_063118305.1  neutral ceramidase isoform X1

      UniProtKB/Swiss-Prot
      Q91XT9
      UniProtKB/TrEMBL
      A0A8L2Q853, A6I102
    11. XM_039107050.2XP_038962978.1  neutral ceramidase isoform X1

      UniProtKB/Swiss-Prot
      Q91XT9
      UniProtKB/TrEMBL
      A0A8L2Q853, A6I102
      Related
      ENSRNOP00000104976.1, ENSRNOT00000128918.1
      Conserved Domains (2) summary
      pfam04734
      Location:83589
      Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
      pfam17048
      Location:591758
      Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
    12. XM_039107116.2XP_038963044.1  neutral ceramidase isoform X1

      UniProtKB/Swiss-Prot
      Q91XT9
      UniProtKB/TrEMBL
      A0A8L2Q853, A6I102
      Conserved Domains (2) summary
      pfam04734
      Location:83589
      Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
      pfam17048
      Location:591758
      Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
    13. XM_017588650.3XP_017444139.1  neutral ceramidase isoform X1

      UniProtKB/Swiss-Prot
      Q91XT9
      UniProtKB/TrEMBL
      A0A8L2Q853, A6I102
      Conserved Domains (2) summary
      pfam04734
      Location:83589
      Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
      pfam17048
      Location:591758
      Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
    14. XM_039106911.2XP_038962839.1  neutral ceramidase isoform X1

      UniProtKB/Swiss-Prot
      Q91XT9
      UniProtKB/TrEMBL
      A0A8L2Q853, A6I102
      Conserved Domains (2) summary
      pfam04734
      Location:83589
      Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
      pfam17048
      Location:591758
      Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
    15. XM_039106878.2XP_038962806.1  neutral ceramidase isoform X1

      UniProtKB/Swiss-Prot
      Q91XT9
      UniProtKB/TrEMBL
      A0A8L2Q853, A6I102
      Conserved Domains (2) summary
      pfam04734
      Location:83589
      Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
      pfam17048
      Location:591758
      Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
    16. XM_017588648.3XP_017444137.1  neutral ceramidase isoform X1

      UniProtKB/Swiss-Prot
      Q91XT9
      UniProtKB/TrEMBL
      A0A8L2Q853, A6I102
      Conserved Domains (2) summary
      pfam04734
      Location:83589
      Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
      pfam17048
      Location:591758
      Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
    17. XM_039106873.2XP_038962801.1  neutral ceramidase isoform X1

      UniProtKB/Swiss-Prot
      Q91XT9
      UniProtKB/TrEMBL
      A0A8L2Q853, A6I102
      Conserved Domains (2) summary
      pfam04734
      Location:83589
      Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
      pfam17048
      Location:591758
      Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
    18. XM_017588647.3XP_017444136.1  neutral ceramidase isoform X1

      UniProtKB/Swiss-Prot
      Q91XT9
      UniProtKB/TrEMBL
      A0A8L2Q853, A6I102
      Conserved Domains (2) summary
      pfam04734
      Location:83589
      Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
      pfam17048
      Location:591758
      Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
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