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OR10H3 olfactory receptor family 10 subfamily H member 3 [ Homo sapiens (human) ]

Gene ID: 26532, updated on 10-Dec-2024

Summary

Official Symbol
OR10H3provided by HGNC
Official Full Name
olfactory receptor family 10 subfamily H member 3provided by HGNC
Primary source
HGNC:HGNC:8174
See related
Ensembl:ENSG00000171936 AllianceGenome:HGNC:8174
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See OR10H3 in Genome Data Viewer
Location:
19p13.12
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (15737985..15742343)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (15864611..15868970)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (15848795..15853153)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 4 subfamily F member 12 Neighboring gene olfactory receptor family 10 subfamily H member 2 Neighboring gene cytochrome P450 family 4 subfamily F member 24, pseudogene Neighboring gene olfactory receptor family 10 subfamily H member 5

Genomic regions, transcripts, and products

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of olfactory receptor, family 10, subfamily H, member 3 (OR10H3) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC119147, MGC119149

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity  
enables olfactory receptor activity  
Component Evidence Code Pubs
is_active_in plasma membrane  

General protein information

Preferred Names
olfactory receptor 10H3
Names
olfactory receptor OR19-24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013938.2NP_039226.1  olfactory receptor 10H3

    See identical proteins and their annotated locations for NP_039226.1

    Status: VALIDATED

    Source sequence(s)
    AC004597, AC104533
    Consensus CDS
    CCDS12334.1
    UniProtKB/Swiss-Prot
    O60404, Q2HIZ3, Q6IFQ0
    UniProtKB/TrEMBL
    A0A126GW93, A0A2R8Y5B6
    Related
    ENSP00000493287.1, ENST00000641646.1
    Conserved Domains (1) summary
    cl21561
    Location:42310
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    15737985..15742343
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    15864611..15868970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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