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RNLS renalase, FAD dependent amine oxidase [ Homo sapiens (human) ]

Gene ID: 55328, updated on 10-Dec-2024

Summary

Official Symbol
RNLSprovided by HGNC
Official Full Name
renalase, FAD dependent amine oxidaseprovided by HGNC
Primary source
HGNC:HGNC:25641
See related
Ensembl:ENSG00000184719 MIM:609360; AllianceGenome:HGNC:25641
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C10orf59; RENALASE
Summary
Enables several functions, including NADH binding activity; epinephrine binding activity; and monoamine oxidase activity. Involved in negative regulation of blood pressure and negative regulation of heart rate. Located in extracellular region. Implicated in essential hypertension and hypertension. Biomarker of end stage renal disease. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See RNLS in Genome Data Viewer
Location:
10q23.31
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (88171523..88583318, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (89050656..89467392, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (90033619..90343075, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378415 Neighboring gene Sharpr-MPRA regulatory region 10781 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3718 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3719 Neighboring gene uncharacterized LOC105378416 Neighboring gene uncharacterized LOC101929727 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3720 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3721 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3722 Neighboring gene vomeronasal 1 receptor 55 pseudogene Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:90107282-90107945 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3723 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3724 Neighboring gene lipase family member J Neighboring gene ribosomal protein L7 pseudogene 34 Neighboring gene lipase F, gastric type

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
EBI GWAS Catalog

Pathways from PubChem

Interactions

General gene information

Clone Names

  • FLJ11218

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in extracellular region  
located_in extracellular region PubMed 
located_in extracellular region  
located_in extracellular space  

General protein information

Preferred Names
renalase
Names
MAO-C
alpha-NAD(P)H oxidase/anomerase
monoamine oxidase-C
NP_001026879.2
NP_060833.1
XP_005270004.1
XP_005270005.1
XP_005270006.1
XP_011538226.1
XP_011538229.1
XP_016871869.1
XP_016871870.1
XP_016871871.1
XP_016871873.1
XP_016871874.1
XP_047281391.1
XP_047281392.1
XP_054222197.1
XP_054222198.1
XP_054222199.1
XP_054222200.1
XP_054222201.1
XP_054222202.1
XP_054222203.1
XP_054222204.1
XP_054222205.1
XP_054222206.1
XP_054222207.1
XP_054222208.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031709.3NP_001026879.2  renalase isoform 1 precursor

    See identical proteins and their annotated locations for NP_001026879.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA854849, AL353149, BC005364, BM978857, BP332262
    Consensus CDS
    CCDS31239.1
    UniProtKB/Swiss-Prot
    Q5VYX0, Q9BS33, Q9NUP8
    Related
    ENSP00000332530.4, ENST00000331772.9
    Conserved Domains (3) summary
    COG3380
    Location:1342
    COG3380; Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]
    pfam13450
    Location:680
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:109226
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. NM_018363.4NP_060833.1  renalase isoform 2 precursor

    See identical proteins and their annotated locations for NP_060833.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK002080, AL353149, BP332262
    Consensus CDS
    CCDS7388.1
    UniProtKB/Swiss-Prot
    Q5VYX0
    Related
    ENSP00000361015.3, ENST00000371947.7
    Conserved Domains (2) summary
    pfam13450
    Location:680
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:109226
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    88171523..88583318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016382.3XP_016871871.1  renalase isoform X8

    UniProtKB/TrEMBL
    B4DJW3
    Conserved Domains (1) summary
    pfam13450
    Location:640
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  2. XM_011539924.4XP_011538226.1  renalase isoform X1

    See identical proteins and their annotated locations for XP_011538226.1

    UniProtKB/Swiss-Prot
    Q5VYX0
    Conserved Domains (2) summary
    pfam13450
    Location:680
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:109226
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. XM_017016380.3XP_016871869.1  renalase isoform X1

    UniProtKB/Swiss-Prot
    Q5VYX0
    Conserved Domains (2) summary
    pfam13450
    Location:680
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:109226
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. XM_017016384.3XP_016871873.1  renalase isoform X10

  5. XM_005269948.4XP_005270005.1  renalase isoform X6

    Conserved Domains (2) summary
    COG3380
    Location:41259
    COG3380; Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]
    pfam13450
    Location:640
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  6. XM_005269947.3XP_005270004.1  renalase isoform X5

    Conserved Domains (2) summary
    pfam13450
    Location:680
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:109226
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  7. XM_017016385.2XP_016871874.1  renalase isoform X11

  8. XM_047425436.1XP_047281392.1  renalase isoform X9

  9. XM_011539927.4XP_011538229.1  renalase isoform X3

    Conserved Domains (2) summary
    pfam13450
    Location:680
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:109226
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  10. XM_047425435.1XP_047281391.1  renalase isoform X2

  11. XM_017016381.3XP_016871870.1  renalase isoform X4

  12. XM_005269949.6XP_005270006.1  renalase isoform X7

    Conserved Domains (2) summary
    pfam13450
    Location:680
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:109226
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RNA

  1. XR_001747122.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    89050656..89467392 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366230.1XP_054222205.1  renalase isoform X8

  2. XM_054366222.1XP_054222197.1  renalase isoform X1

  3. XM_054366223.1XP_054222198.1  renalase isoform X1

  4. XM_054366229.1XP_054222204.1  renalase isoform X8

  5. XM_054366232.1XP_054222207.1  renalase isoform X10

  6. XM_054366227.1XP_054222202.1  renalase isoform X6

  7. XM_054366226.1XP_054222201.1  renalase isoform X5

  8. XM_054366233.1XP_054222208.1  renalase isoform X11

  9. XM_054366231.1XP_054222206.1  renalase isoform X9

  10. XM_054366224.1XP_054222199.1  renalase isoform X3

  11. XM_054366225.1XP_054222200.1  renalase isoform X4

  12. XM_054366228.1XP_054222203.1  renalase isoform X7

RNA

  1. XR_008488226.1 RNA Sequence

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