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    Fosb FBJ osteosarcoma oncogene B [ Mus musculus (house mouse) ]

    Gene ID: 14282, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fosbprovided by MGI
    Official Full Name
    FBJ osteosarcoma oncogene Bprovided by MGI
    Primary source
    MGI:MGI:95575
    See related
    Ensembl:ENSMUSG00000003545 AllianceGenome:MGI:95575
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within cellular response to calcium ion. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; gut; male reproductive gland or organ; skeleton; and skin. Orthologous to human FOSB (FosB proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 2.7), small intestine adult (RPKM 1.8) and 18 other tissues See more
    Orthologs
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    Genomic context

    See Fosb in Genome Data Viewer
    Location:
    7 A3; 7 9.56 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19036621..19043970, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19302696..19310118, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene reticulon 2 (Z-band associated protein) Neighboring gene STARR-positive B cell enhancer ABC_E1082 Neighboring gene nuclear encoded tRNA selenocysteine 2 (anticodon TCA) Neighboring gene STARR-positive B cell enhancer ABC_E9021 Neighboring gene STARR-positive B cell enhancer ABC_E11736 Neighboring gene RIKEN cDNA D830036C21 gene Neighboring gene VISTA enhancer mm567 Neighboring gene STARR-positive B cell enhancer ABC_E10427 Neighboring gene STARR-positive B cell enhancer ABC_E1719 Neighboring gene excision repair cross-complementing rodent repair deficiency, complementation group 1 Neighboring gene RNA polymerase I subunit G

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (9)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in behavioral response to cocaine  
    acts_upstream_of_or_within cellular response to calcium ion PubMed 
    involved_in cellular response to hormone stimulus  
    involved_in female pregnancy  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    involved_in response to amphetamine  
    involved_in response to cAMP  
    involved_in response to corticosterone  
    involved_in response to ethanol  
    involved_in response to mechanical stimulus  
    involved_in response to morphine  
    involved_in response to progesterone  
    involved_in response to xenobiotic stimulus  
    involved_in transcription by RNA polymerase II  
    involved_in transcription by RNA polymerase II  
    Component Evidence Code Pubs
    located_in cytosol  
    located_in cytosol  
    located_in intracellular membrane-bounded organelle  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    protein FosB
    Names
    osteosarcoma oncoprotein B FosB
    protein fosB
    transcription factor AP-1 subunit FosB

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347586.1NP_001334515.1  protein FosB isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region which results in a frameshift, compared to variant 1. This difference results in a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1
      Source sequence(s)
      AC148988, AI846927, BC145082
      Consensus CDS
      CCDS85225.1
      UniProtKB/TrEMBL
      A0A140LIE4
      Related
      ENSMUSP00000146789.2, ENSMUST00000208446.2
      Conserved Domains (1) summary
      cd14721
      Location:165218
      bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain
    2. NM_008036.2NP_032062.1  protein FosB isoform 1

      See identical proteins and their annotated locations for NP_032062.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC148988, AI846927, BU698478, BY337108, BY547195, CF356426, CK795975
      Consensus CDS
      CCDS20897.1
      UniProtKB/Swiss-Prot
      A0A140LIE4, P13346
      UniProtKB/TrEMBL
      A0A140LHW0, A2RSD4
      Related
      ENSMUSP00000003640.3, ENSMUST00000003640.4
      Conserved Domains (1) summary
      cd14721
      Location:165218
      bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      19036621..19043970 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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