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    Il6st interleukin 6 signal transducer [ Mus musculus (house mouse) ]

    Gene ID: 16195, updated on 9-Dec-2024

    Summary

    Official Symbol
    Il6stprovided by MGI
    Official Full Name
    interleukin 6 signal transducerprovided by MGI
    Primary source
    MGI:MGI:96560
    See related
    Ensembl:ENSMUSG00000021756 AllianceGenome:MGI:96560
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD130; gp130; D13Ertd699e; 5133400A03Rik
    Summary
    Contributes to interleukin-11 binding activity and interleukin-11 receptor activity. Involved in interleukin-6-mediated signaling pathway; intestinal epithelial cell development; and positive regulation of Notch signaling pathway. Acts upstream of or within several processes, including glycogen metabolic process; positive regulation of astrocyte differentiation; and regulation of Notch signaling pathway. Located in dendrite; external side of plasma membrane; and neuronal cell body. Is expressed in several structures, including alimentary system; brain; early conceptus; hemolymphoid system; and reproductive system. Used to study rheumatoid arthritis and stomach cancer. Human ortholog(s) of this gene implicated in arteriosclerosis; hyper IgE recurrent infection syndrome 4; hyperandrogenism; and primary immunodeficiency disease. Orthologous to human IL6ST (interleukin 6 cytokine family signal transducer). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 57.5), subcutaneous fat pad adult (RPKM 32.9) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Il6st in Genome Data Viewer
    Location:
    13 D2.2; 13 63.73 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (112600604..112643394)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (112464070..112506860)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 55 Neighboring gene predicted gene, 48837 Neighboring gene STARR-positive B cell enhancer mm9_chr13:113188373-113188674 Neighboring gene STARR-seq mESC enhancer starr_35690 Neighboring gene STARR-seq mESC enhancer starr_35691 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:113214843-113215211 Neighboring gene predicted gene, 33905 Neighboring gene STARR-positive B cell enhancer mm9_chr13:113223673-113223974 Neighboring gene STARR-positive B cell enhancers ABC_E5418 and ABC_E4097 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:113229709-113229897 Neighboring gene STARR-positive B cell enhancer ABC_E1890 Neighboring gene STARR-positive B cell enhancer ABC_E8545 Neighboring gene STARR-seq mESC enhancer starr_35693 Neighboring gene interleukin 31 receptor A Neighboring gene tubulin, alpha 1B pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 30
    Function Evidence Code Pubs
    enables ciliary neurotrophic factor receptor activity  
    enables ciliary neurotrophic factor receptor binding  
    enables ciliary neurotrophic factor receptor binding  
    enables coreceptor activity  
    enables coreceptor activity  
    enables cytokine binding  
    enables cytokine receptor activity  
    contributes_to growth factor binding  
    enables growth factor binding  
    enables identical protein binding  
    enables identical protein binding  
    contributes_to interleukin-11 binding PubMed 
    contributes_to interleukin-11 receptor activity PubMed 
    contributes_to interleukin-6 binding  
    enables interleukin-6 binding  
    contributes_to interleukin-6 binding  
    contributes_to interleukin-6 receptor activity  
    enables interleukin-6 receptor activity  
    contributes_to interleukin-6 receptor activity  
    enables interleukin-6 receptor binding  
    contributes_to interleukin-6 receptor binding  
    enables leukemia inhibitory factor receptor activity  
    contributes_to leukemia inhibitory factor receptor activity  
    enables oncostatin-M receptor activity  
    contributes_to oncostatin-M receptor activity  
    enables protein binding PubMed 
    enables protein tyrosine kinase activator activity  
    enables protein tyrosine kinase activator activity  
    enables scaffold protein binding  
    enables scaffold protein binding  
    Items 1 - 25 of 30
    Items 1 - 25 of 39
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway via STAT  
    involved_in ciliary neurotrophic factor-mediated signaling pathway  
    involved_in ciliary neurotrophic factor-mediated signaling pathway  
    involved_in cytokine-mediated signaling pathway  
    acts_upstream_of_or_within cytokine-mediated signaling pathway PubMed 
    involved_in cytokine-mediated signaling pathway  
    acts_upstream_of_or_within glycogen metabolic process PubMed 
    involved_in interleukin-11-mediated signaling pathway  
    involved_in interleukin-11-mediated signaling pathway  
    involved_in interleukin-27-mediated signaling pathway  
    involved_in interleukin-27-mediated signaling pathway  
    involved_in interleukin-6-mediated signaling pathway PubMed 
    involved_in interleukin-6-mediated signaling pathway  
    involved_in intestinal epithelial cell development PubMed 
    involved_in intestinal epithelial cell development  
    involved_in leukemia inhibitory factor signaling pathway  
    involved_in leukemia inhibitory factor signaling pathway  
    involved_in negative regulation of cytosolic calcium ion concentration  
    involved_in negative regulation of interleukin-6-mediated signaling pathway  
    involved_in negative regulation of neuron apoptotic process  
    involved_in negative regulation of neuron apoptotic process  
    involved_in oncostatin-M-mediated signaling pathway  
    involved_in oncostatin-M-mediated signaling pathway  
    involved_in positive regulation of Notch signaling pathway PubMed 
    involved_in positive regulation of Notch signaling pathway  
    involved_in positive regulation of T cell proliferation  
    involved_in positive regulation of T cell proliferation  
    acts_upstream_of_or_within positive regulation of astrocyte differentiation PubMed 
    involved_in positive regulation of cell population proliferation  
    acts_upstream_of_or_within positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of osteoblast differentiation  
    involved_in positive regulation of osteoblast differentiation  
    involved_in positive regulation of smooth muscle cell migration  
    involved_in positive regulation of tyrosine phosphorylation of STAT protein  
    acts_upstream_of_or_within regulation of Notch signaling pathway PubMed 
    involved_in response to cytokine  
    acts_upstream_of_or_within signal transduction PubMed 
    involved_in triglyceride mobilization  
    Items 1 - 25 of 39
    Component Evidence Code Pubs
    located_in cell body PubMed 
    part_of ciliary neurotrophic factor receptor complex  
    part_of ciliary neurotrophic factor receptor complex  
    located_in dendrite PubMed 
    is_active_in external side of plasma membrane  
    located_in external side of plasma membrane PubMed 
    located_in extracellular space  
    part_of interleukin-6 receptor complex  
    part_of interleukin-6 receptor complex  
    located_in membrane raft  
    is_active_in membrane raft  
    located_in neuronal cell body PubMed 
    located_in neuronal cell body membrane  
    part_of oncostatin-M receptor complex  
    part_of oncostatin-M receptor complex  
    is_active_in plasma membrane  
    part_of receptor complex  

    General protein information

    Preferred Names
    interleukin-6 receptor subunit beta
    Names
    IL-6 receptor subunit beta
    IL-6R subunit beta
    IL-6R-beta
    IL-6RB
    membrane glycoprotein 130
    oncostatin-M receptor subunit alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010560.3NP_034690.3  interleukin-6 receptor subunit beta precursor

      See identical proteins and their annotated locations for NP_034690.3

      Status: VALIDATED

      Source sequence(s)
      BC058679, BU709006, CJ177012, CV556562
      Consensus CDS
      CCDS26773.1
      UniProtKB/Swiss-Prot
      G5E8D2, Q00560
      UniProtKB/TrEMBL
      H6WCS3, Q6PDI9
      Related
      ENSMUSP00000138836.2, ENSMUST00000183663.8
      Conserved Domains (4) summary
      smart00060
      Location:521597
      FN3; Fibronectin type 3 domain
      cd00063
      Location:220319
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:26112
      Lep_receptor_Ig; Ig-like C2-type domain
      cl21522
      Location:125213
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      112600604..112643394
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157858.1XP_036013751.1  interleukin-6 receptor subunit beta isoform X1

      UniProtKB/Swiss-Prot
      G5E8D2, Q00560
      UniProtKB/TrEMBL
      H6WCS3, Q6PDI9
      Conserved Domains (4) summary
      smart00060
      Location:521597
      FN3; Fibronectin type 3 domain
      cd00063
      Location:220319
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:26112
      Lep_receptor_Ig; Ig-like C2-type domain
      cl21522
      Location:125213
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
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