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Prim1 DNA primase, p49 subunit [ Mus musculus (house mouse) ]

Gene ID: 19075, updated on 24-Dec-2024

Summary

Official Symbol
Prim1provided by MGI
Official Full Name
DNA primase, p49 subunitprovided by MGI
Primary source
MGI:MGI:97757
See related
Ensembl:ENSMUSG00000025395 AllianceGenome:MGI:97757
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables DNA primase activity. Involved in DNA replication initiation and DNA replication, synthesis of primer. Part of alpha DNA polymerase:primase complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PRIM1 (DNA primase subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in liver E14 (RPKM 29.4), CNS E11.5 (RPKM 24.3) and 15 other tissues See more
Orthologs
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Genomic context

See Prim1 in Genome Data Viewer
Location:
10 76.39 cM; 10 D3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127851084..127865899)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128015215..128030030)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene hydroxysteroid (17-beta) dehydrogenase 6 Neighboring gene STARR-positive B cell enhancer ABC_E8376 Neighboring gene STARR-positive B cell enhancer ABC_E9812 Neighboring gene small nuclear ribonucleoprotein D2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_28254 Neighboring gene nascent polypeptide-associated complex alpha polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E5198 Neighboring gene STARR-positive B cell enhancer ABC_E10658 Neighboring gene prostaglandin E synthase 3 Neighboring gene predicted gene, 47438

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC107288

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA primase activity  
enables DNA primase activity PubMed 
enables DNA primase activity  
enables magnesium ion binding  
enables magnesium ion binding  
enables protein binding PubMed 
enables ribonucleotide binding  
enables ribonucleotide binding  
enables zinc ion binding  
enables zinc ion binding  
Component Evidence Code Pubs
part_of alpha DNA polymerase:primase complex  
part_of alpha DNA polymerase:primase complex PubMed 
part_of alpha DNA polymerase:primase complex PubMed 
part_of alpha DNA polymerase:primase complex  

General protein information

Preferred Names
DNA primase small subunit
Names
DNA primase 49 kDa subunit
p49
NP_032947.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008921.2NP_032947.1  DNA primase small subunit

    See identical proteins and their annotated locations for NP_032947.1

    Status: PROVISIONAL

    Source sequence(s)
    AC131120
    Consensus CDS
    CCDS36086.1
    UniProtKB/Swiss-Prot
    P20664
    UniProtKB/TrEMBL
    Q3UZF0, Q5FW94
    Related
    ENSMUSP00000026461.8, ENSMUST00000026461.8
    Conserved Domains (1) summary
    cd04860
    Location:26343
    AE_Prim_S; AE_Prim_S: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. Primases are DNA-dependent RNA polymerases which synthesis the short RNA primers required for DNA replication. In addition to its ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    127851084..127865899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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