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VNN1 vanin 1 [ Homo sapiens (human) ]

Gene ID: 8876, updated on 10-Dec-2024

Summary

Official Symbol
VNN1provided by HGNC
Official Full Name
vanin 1provided by HGNC
Primary source
HGNC:HGNC:12705
See related
Ensembl:ENSG00000112299 MIM:603570; AllianceGenome:HGNC:12705
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HDLCQ8; Tiff66
Summary
This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24. [provided by RefSeq, Feb 2009]
Expression
Biased expression in duodenum (RPKM 74.9), liver (RPKM 69.9) and 5 other tissues See more
Orthologs
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Genomic context

See VNN1 in Genome Data Viewer
Location:
6q23.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (132680849..132714055, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (133875818..133909022, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (133001988..133035194, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17551 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17552 Neighboring gene trace amine associated receptor 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:133004442-133005641 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_89871 Neighboring gene HLF pseudogene 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_89876 Neighboring gene cyclin G1 pseudogene 1 Neighboring gene vanin 3, pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:133069914-133071113 Neighboring gene vanin 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25073 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25074

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC116930, MGC116931, MGC116932, MGC116933

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in acute inflammatory response PubMed 
involved_in cell-cell adhesion PubMed 
involved_in chronic inflammatory response PubMed 
involved_in coenzyme A catabolic process  
involved_in inflammatory response PubMed 
involved_in innate immune response PubMed 
involved_in pantothenate metabolic process  
involved_in pantothenate metabolic process PubMed 
involved_in pantothenate metabolic process  
involved_in positive regulation of T cell differentiation in thymus PubMed 
involved_in positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway PubMed 
involved_in response to oxidative stress PubMed 
Component Evidence Code Pubs
located_in azurophil granule membrane  
located_in extracellular region  
located_in membrane PubMed 
located_in plasma membrane  
located_in side of membrane  

General protein information

Preferred Names
pantetheinase
Names
pantetheine hydrolase
vannin 1
vascular non-inflammatory molecule 1
NP_004657.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012147.1 RefSeqGene

    Range
    5001..38207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004666.3NP_004657.2  pantetheinase precursor

    See identical proteins and their annotated locations for NP_004657.2

    Status: REVIEWED

    Source sequence(s)
    AL032821, BC096266, BJ995136
    Consensus CDS
    CCDS5159.1
    UniProtKB/Swiss-Prot
    A8K310, O95497, Q4JFW6, Q4VAS7, Q4VAS8, Q4VAS9, Q9UF16, Q9UJF4
    UniProtKB/TrEMBL
    B2RAN2
    Related
    ENSP00000356905.4, ENST00000367928.5
    Conserved Domains (1) summary
    cd07567
    Location:25330
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    132680849..132714055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    133875818..133909022 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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