U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Eif4enif1 eukaryotic translation initiation factor 4E nuclear import factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 74203, updated on 9-Dec-2024

    Summary

    Official Symbol
    Eif4enif1provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 4E nuclear import factor 1provided by MGI
    Primary source
    MGI:MGI:1921453
    See related
    Ensembl:ENSMUSG00000020454 AllianceGenome:MGI:1921453
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Clast4; D11Ertd166e; 2610509L04Rik; A930019J01Rik
    Summary
    Enables mRNA binding activity. Acts upstream of or within negative regulation of neuron differentiation; negative regulation of translation; and stem cell population maintenance. Located in P-body; cytosol; and nucleus. Is expressed in several structures, including cerebral cortex; early conceptus; epithelium; metanephros; and ovary. Orthologous to human EIF4ENIF1 (eukaryotic translation initiation factor 4E nuclear import factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 18.2), CNS E11.5 (RPKM 15.6) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Eif4enif1 in Genome Data Viewer
    Location:
    11 A1; 11 2.24 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3152344..3194588)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3202343..3244588)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Sfi1 homolog, spindle assembly associated (yeast) Neighboring gene elongation factor 2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6943 Neighboring gene Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived), pseudogene 2 Neighboring gene predicted gene, 51877 Neighboring gene developmentally regulated GTP binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_28343 Neighboring gene STARR-seq mESC enhancer starr_28345 Neighboring gene POZ (BTB) and AT hook containing zinc finger 1 Neighboring gene predicted gene 12592 Neighboring gene predicted gene 11944

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables kinase binding  
    enables kinase binding  
    enables mRNA binding  
    enables mRNA binding PubMed 
    enables nuclear export signal receptor activity  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in P-body assembly  
    involved_in P-body assembly  
    involved_in mRNA stabilization  
    involved_in mRNA stabilization  
    acts_upstream_of_positive_effect miRNA-mediated gene silencing by inhibition of translation  
    acts_upstream_of_positive_effect miRNA-mediated gene silencing by inhibition of translation  
    involved_in negative regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA  
    involved_in negative regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA  
    acts_upstream_of_or_within negative regulation of neuron differentiation PubMed 
    involved_in negative regulation of translation  
    acts_upstream_of_or_within negative regulation of translation PubMed 
    involved_in negative regulation of translation  
    involved_in negative regulation of translation  
    acts_upstream_of neuron differentiation PubMed 
    involved_in nuclear export  
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  
    involved_in protein import into nucleus  
    involved_in protein import into nucleus  
    acts_upstream_of_or_within stem cell population maintenance PubMed 
    acts_upstream_of translation PubMed 
    Component Evidence Code Pubs
    located_in P-body PubMed 
    located_in P-body  
    located_in PML body  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytosol PubMed 
    located_in intracellular membrane-bounded organelle  
    located_in nuclear speck  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 4E transporter
    Names
    4E-T
    CD40 ligand-activated specific transcript 4
    eIF4E transporter

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166547.1NP_001160019.1  eukaryotic translation initiation factor 4E transporter isoform a

      See identical proteins and their annotated locations for NP_001160019.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.
      Source sequence(s)
      AK165678, BC033410
      Consensus CDS
      CCDS24354.1
      UniProtKB/Swiss-Prot
      Q8CFW0, Q9CSS3, Q9EST3
      UniProtKB/TrEMBL
      Q8BY82
      Related
      ENSMUSP00000136768.2, ENSMUST00000179770.8
      Conserved Domains (2) summary
      pfam03154
      Location:707934
      Atrophin-1; Atrophin-1 family
      pfam10477
      Location:29710
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
    2. NM_001166548.1NP_001160020.1  eukaryotic translation initiation factor 4E transporter isoform b

      See identical proteins and their annotated locations for NP_001160020.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AK041598, BC033410, CJ072393
      Consensus CDS
      CCDS48739.1
      UniProtKB/TrEMBL
      Q8BY82
      Related
      ENSMUSP00000020734.5, ENSMUST00000020734.11
      Conserved Domains (2) summary
      pfam03154
      Location:683910
      Atrophin-1; Atrophin-1 family
      pfam10477
      Location:29686
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
    3. NM_001166549.1NP_001160021.1  eukaryotic translation initiation factor 4E transporter isoform b

      See identical proteins and their annotated locations for NP_001160021.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      BC033410, BY068596
      Consensus CDS
      CCDS48739.1
      UniProtKB/TrEMBL
      Q8BY82
      Related
      ENSMUSP00000105675.2, ENSMUST00000110048.8
      Conserved Domains (2) summary
      pfam03154
      Location:683910
      Atrophin-1; Atrophin-1 family
      pfam10477
      Location:29686
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
    4. NM_023743.2NP_076232.2  eukaryotic translation initiation factor 4E transporter isoform a

      See identical proteins and their annotated locations for NP_076232.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 2 both encode isoform a.
      Source sequence(s)
      AL671968, BC033410
      Consensus CDS
      CCDS24354.1
      UniProtKB/Swiss-Prot
      Q8CFW0, Q9CSS3, Q9EST3
      UniProtKB/TrEMBL
      Q8BY82
      Related
      ENSMUSP00000105676.2, ENSMUST00000110049.8
      Conserved Domains (2) summary
      pfam03154
      Location:707934
      Atrophin-1; Atrophin-1 family
      pfam10477
      Location:29710
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      3152344..3194588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514842.5XP_006514905.1  eukaryotic translation initiation factor 4E transporter isoform X1

      See identical proteins and their annotated locations for XP_006514905.1

      UniProtKB/Swiss-Prot
      Q8CFW0, Q9CSS3, Q9EST3
      UniProtKB/TrEMBL
      Q8BY82
      Conserved Domains (2) summary
      pfam03154
      Location:707934
      Atrophin-1; Atrophin-1 family
      pfam10477
      Location:29710
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
    2. XM_006514844.4XP_006514907.1  eukaryotic translation initiation factor 4E transporter isoform X2

      See identical proteins and their annotated locations for XP_006514907.1

      UniProtKB/TrEMBL
      Q8BY82
      Conserved Domains (2) summary
      pfam03154
      Location:683910
      Atrophin-1; Atrophin-1 family
      pfam10477
      Location:29686
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
    3. XM_006514841.4XP_006514904.1  eukaryotic translation initiation factor 4E transporter isoform X1

      See identical proteins and their annotated locations for XP_006514904.1

      UniProtKB/Swiss-Prot
      Q8CFW0, Q9CSS3, Q9EST3
      UniProtKB/TrEMBL
      Q8BY82
      Conserved Domains (2) summary
      pfam03154
      Location:707934
      Atrophin-1; Atrophin-1 family
      pfam10477
      Location:29710
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
    4. XM_017314806.3XP_017170295.1  eukaryotic translation initiation factor 4E transporter isoform X2

      UniProtKB/TrEMBL
      Q8BY82
      Conserved Domains (2) summary
      pfam03154
      Location:683910
      Atrophin-1; Atrophin-1 family
      pfam10477
      Location:29686
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
    5. XM_006514843.5XP_006514906.1  eukaryotic translation initiation factor 4E transporter isoform X1

      See identical proteins and their annotated locations for XP_006514906.1

      UniProtKB/Swiss-Prot
      Q8CFW0, Q9CSS3, Q9EST3
      UniProtKB/TrEMBL
      Q8BY82
      Conserved Domains (2) summary
      pfam03154
      Location:707934
      Atrophin-1; Atrophin-1 family
      pfam10477
      Location:29710
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
    External link. Please review our privacy policy.