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Dhx15 DEAH-box helicase 15 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289693, updated on 9-Dec-2024

Summary

Symbol
Dhx15provided by RGD
Full Name
DEAH-box helicase 15provided by RGD
Primary source
RGD:1308072
See related
EnsemblRapid:ENSRNOG00000003844 AllianceGenome:RGD:1308072
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA helicase activity and double-stranded RNA binding activity. Involved in response to alkaloid and response to toxic substance. Predicted to be located in nuclear speck. Predicted to be part of U12-type spliceosomal complex and U2-type post-mRNA release spliceosomal complex. Orthologous to human DHX15 (DEAH-box helicase 15). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Thymus (RPKM 807.7), Spleen (RPKM 550.4) and 9 other tissues See more
Orthologs
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Genomic context

See Dhx15 in Genome Data Viewer
Location:
14q11
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (62999886..63037829)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (58787147..58825083)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (61136740..61174880)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481756 Neighboring gene uncharacterized LOC108352757 Neighboring gene ribosomal protein L36, pseudogene Neighboring gene PPARG coactivator 1 alpha Neighboring gene high mobility group nucleosome binding domain 1, pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding  
enables RNA binding  
enables RNA binding  
enables RNA helicase activity  
enables double-stranded RNA binding  
enables helicase activity  
enables hydrolase activity  
Process Evidence Code Pubs
involved_in RNA splicing  
involved_in antiviral innate immune response  
involved_in defense response to bacterium  
involved_in defense response to virus  
involved_in mRNA processing  
involved_in positive regulation of canonical NF-kappaB signal transduction  
involved_in response to alkaloid PubMed 
involved_in response to toxic substance PubMed 
Component Evidence Code Pubs
part_of U12-type spliceosomal complex  
part_of U2-type post-mRNA release spliceosomal complex  
located_in membrane  
located_in nuclear speck  
located_in nuclear speck  
part_of spliceosomal complex  

General protein information

Preferred Names
ATP-dependent RNA helicase DHX15
Names
DEAH (Asp-Glu-Ala-His) box helicase 15
DEAH (Asp-Glu-Ala-His) box polypeptide 15
pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15
pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15-like
putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15
putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15-like
NP_001178526.1
XP_063129005.1
XP_063129006.1
XP_063129007.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191597.1NP_001178526.1  ATP-dependent RNA helicase DHX15

    See identical proteins and their annotated locations for NP_001178526.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A6IJI2, D3ZD97
    Related
    ENSRNOP00000005126.6, ENSRNOT00000005126.8
    Conserved Domains (1) summary
    COG1643
    Location:124763
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    62999886..63037829
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272935.1XP_063129005.1  ATP-dependent RNA helicase DHX15 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZT94
  2. XM_063272936.1XP_063129006.1  ATP-dependent RNA helicase DHX15 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZT94
  3. XM_063272937.1XP_063129007.1  ATP-dependent RNA helicase DHX15 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZT94
    Related
    ENSRNOP00000081583.1, ENSRNOT00000103809.2

RNA

  1. XR_005492917.2 RNA Sequence

  2. XR_005492918.2 RNA Sequence

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