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    Ccl5 C-C motif chemokine ligand 5 [ Mus musculus (house mouse) ]

    Gene ID: 20304, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ccl5provided by MGI
    Official Full Name
    C-C motif chemokine ligand 5provided by MGI
    Primary source
    MGI:MGI:98262
    See related
    Ensembl:ENSMUSG00000035042 AllianceGenome:MGI:98262
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SISd; Scya5; RANTES; TCP228; MuRantes
    Summary
    Enables CCR1 chemokine receptor binding activity. Involved in negative regulation of macrophage apoptotic process and positive regulation of monocyte chemotaxis. Acts upstream of or within inflammatory response; positive regulation of epithelial cell proliferation; and response to tumor necrosis factor. Located in cytoplasm and extracellular space. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; liver; and retina. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; liver disease (multiple); pulmonary tuberculosis; and severe acute respiratory syndrome. Orthologous to human CCL5 (C-C motif chemokine ligand 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in small intestine adult (RPKM 266.1), mammary gland adult (RPKM 266.0) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Ccl5 in Genome Data Viewer
    Location:
    11 C; 11 50.66 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (83416604..83421344, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (83525778..83530518, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1836 Neighboring gene TATA-box binding protein associated factor 15 Neighboring gene STARR-seq mESC enhancer starr_30202 Neighboring gene STARR-seq mESC enhancer starr_30203 Neighboring gene predicted gene, 32650 Neighboring gene HEAT repeat containing 9 Neighboring gene predicted gene, 23247 Neighboring gene C-C motif chemokine ligand 16, pseudogene Neighboring gene C-C motif chemokine ligand 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CCR chemokine receptor binding  
    enables CCR1 chemokine receptor binding PubMed 
    enables CCR1 chemokine receptor binding  
    enables CCR5 chemokine receptor binding  
    enables CCR5 chemokine receptor binding  
    enables chemoattractant activity  
    enables chemoattractant activity  
    enables chemokine activity  
    enables chemokine activity  
    enables chemokine activity  
    enables chemokine receptor antagonist activity  
    enables chemokine receptor antagonist activity  
    enables chemokine receptor binding  
    enables heparin binding  
    enables identical protein binding  
    enables phosphatidylinositol phospholipase C activity  
    enables phosphatidylinositol phospholipase C activity  
    enables phospholipase activator activity  
    enables phospholipase activator activity  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein kinase activity  
    enables protein kinase activity  
    enables receptor signaling protein tyrosine kinase activator activity  
    enables receptor signaling protein tyrosine kinase activator activity  
    Items 1 - 25 of 101
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway  
    involved_in G protein-coupled receptor signaling pathway  
    involved_in T-helper 1 cell diapedesis  
    involved_in activation of phospholipase D activity  
    involved_in activation of phospholipase D activity  
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide  
    involved_in calcium ion transport  
    involved_in calcium ion transport  
    involved_in cell-cell signaling  
    involved_in cell-cell signaling  
    involved_in cellular response to fibroblast growth factor stimulus  
    involved_in cellular response to interleukin-1  
    involved_in cellular response to tumor necrosis factor  
    involved_in cellular response to type II interferon  
    involved_in cellular response to virus  
    involved_in chemokine (C-C motif) ligand 5 signaling pathway  
    involved_in chemokine-mediated signaling pathway  
    involved_in chemokine-mediated signaling pathway  
    involved_in chemokine-mediated signaling pathway  
    involved_in eosinophil chemotaxis  
    involved_in eosinophil chemotaxis  
    involved_in eosinophil chemotaxis  
    acts_upstream_of epithelial cell proliferation PubMed 
    involved_in exocytosis  
    involved_in exocytosis  
    involved_in inflammatory response  
    acts_upstream_of_or_within inflammatory response PubMed 
    involved_in intracellular calcium ion homeostasis  
    involved_in intracellular calcium ion homeostasis  
    involved_in leukocyte cell-cell adhesion  
    involved_in leukocyte cell-cell adhesion  
    involved_in lymphocyte chemotaxis  
    involved_in negative regulation by host of viral transcription  
    involved_in negative regulation by host of viral transcription  
    involved_in negative regulation of G protein-coupled receptor signaling pathway  
    involved_in negative regulation of T cell apoptotic process  
    involved_in negative regulation of T cell apoptotic process  
    involved_in negative regulation of chemokine-mediated signaling pathway  
    involved_in negative regulation of macrophage apoptotic process PubMed 
    involved_in negative regulation of viral genome replication  
    involved_in negative regulation of viral genome replication  
    involved_in neutrophil activation  
    involved_in neutrophil activation  
    involved_in positive chemotaxis  
    involved_in positive regulation of G protein-coupled receptor signaling pathway  
    involved_in positive regulation of G protein-coupled receptor signaling pathway  
    involved_in positive regulation of T cell apoptotic process  
    involved_in positive regulation of T cell apoptotic process  
    involved_in positive regulation of T cell chemotaxis  
    involved_in positive regulation of T cell chemotaxis  
    acts_upstream_of_or_within positive regulation of T cell migration PubMed 
    involved_in positive regulation of T cell proliferation  
    involved_in positive regulation of T cell proliferation  
    involved_in positive regulation of angiogenesis  
    involved_in positive regulation of biosynthetic process  
    involved_in positive regulation of biosynthetic process  
    involved_in positive regulation of calcium ion transport  
    involved_in positive regulation of calcium ion transport  
    involved_in positive regulation of cell adhesion  
    involved_in positive regulation of cell adhesion  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell-cell adhesion mediated by integrin  
    involved_in positive regulation of cell-cell adhesion mediated by integrin  
    involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production PubMed 
    involved_in positive regulation of defense response to virus by host PubMed 
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation PubMed 
    involved_in positive regulation of fever generation  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of homotypic cell-cell adhesion  
    involved_in positive regulation of homotypic cell-cell adhesion  
    involved_in positive regulation of macrophage chemotaxis  
    involved_in positive regulation of macrophage chemotaxis  
    involved_in positive regulation of mast cell chemotaxis  
    involved_in positive regulation of monocyte chemotaxis PubMed 
    involved_in positive regulation of monocyte chemotaxis  
    involved_in positive regulation of natural killer cell chemotaxis  
    involved_in positive regulation of natural killer cell chemotaxis  
    involved_in positive regulation of neuron differentiation  
    involved_in positive regulation of osteoclast differentiation  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of phosphorylation  
    involved_in positive regulation of phosphorylation  
    involved_in positive regulation of receptor signaling pathway via STAT  
    involved_in positive regulation of smooth muscle cell migration  
    involved_in positive regulation of smooth muscle cell migration  
    involved_in positive regulation of smooth muscle cell proliferation  
    involved_in positive regulation of smooth muscle cell proliferation  
    involved_in positive regulation of tyrosine phosphorylation of STAT protein  
    involved_in pseudopodium assembly  
    involved_in regulation of T cell activation  
    involved_in regulation of T cell activation  
    involved_in regulation of insulin secretion  
    involved_in regulation of insulin secretion  
    involved_in regulation of programmed cell death  
    acts_upstream_of_or_within response to cytokine PubMed 
    involved_in response to toxic substance  
    involved_in response to toxic substance  
    acts_upstream_of_or_within response to tumor necrosis factor PubMed 
    involved_in response to type II interferon  
    Items 1 - 25 of 101
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in extracellular space  

    General protein information

    Preferred Names
    C-C motif chemokine 5
    Names
    SIS-delta
    T-cell-specific protein RANTES
    chemokine (C-C motif) ligand 5
    small-inducible cytokine A5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013653.3NP_038681.2  C-C motif chemokine 5 precursor

      See identical proteins and their annotated locations for NP_038681.2

      Status: VALIDATED

      Source sequence(s)
      AK003101, BE333205
      Consensus CDS
      CCDS36254.1
      UniProtKB/Swiss-Prot
      P30882
      UniProtKB/TrEMBL
      Q5XZF2
      Related
      ENSMUSP00000039600.3, ENSMUST00000035938.3
      Conserved Domains (1) summary
      cd00272
      Location:3389
      Chemokine_CC; Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      83416604..83421344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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