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DZIP3 DAZ interacting zinc finger protein 3 [ Homo sapiens (human) ]

Gene ID: 9666, updated on 10-Dec-2024

Summary

Official Symbol
DZIP3provided by HGNC
Official Full Name
DAZ interacting zinc finger protein 3provided by HGNC
Primary source
HGNC:HGNC:30938
See related
Ensembl:ENSG00000198919 MIM:608672; AllianceGenome:HGNC:30938
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UURF2; PPP1R66; hRUL138
Summary
Enables several functions, including phosphatase binding activity; polyubiquitin modification-dependent protein binding activity; and ubiquitin-protein transferase activity. Involved in protein polyubiquitination. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in testis (RPKM 21.6), brain (RPKM 12.1) and 21 other tissues See more
Orthologs
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Genomic context

See DZIP3 in Genome Data Viewer
Location:
3q13.13
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (108589510..108694840)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (111309763..111415213)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (108308569..108413687)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene myosin heavy chain 15 Neighboring gene ribosomal protein L13 pseudogene 8 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene cellular inhibitor of PP2A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20222 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:108396720-108396891 Neighboring gene uncharacterized LOC105374033 Neighboring gene uncharacterized LOC105374034 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:108462949-108464148

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Clone Names

  • FLJ13327, FLJ57977, FLJ58022, FLJ58223, KIAA0675

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding PubMed 
enables RNA binding  
enables RNA binding PubMed 
enables metal ion binding  
enables phosphatase binding PubMed 
enables polyubiquitin modification-dependent protein binding  
enables polyubiquitin modification-dependent protein binding PubMed 
enables protein binding PubMed 
enables ubiquitin protein ligase activity  
enables ubiquitin-protein transferase activity  
enables ubiquitin-protein transferase activity PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase DZIP3
Names
DAZ interacting protein 3, zinc finger
DAZ-interacting protein 3
RING-type E3 ubiquitin transferase DZIP3
RNA-binding RING-H2 protein-ubiquitin ligase
RNA-binding ubiquitin ligase of 138 kDa
UURF2 ubiquitin ligase
human RNA-binding ubiquitin ligase of 138 kDa
protein phosphatase 1, regulatory subunit 66
zinc finger DAZ interacting protein 3
NP_055463.1
XP_005247971.1
XP_005247972.1
XP_005247973.1
XP_005247974.1
XP_005247975.1
XP_005247976.1
XP_016863029.1
XP_047305210.1
XP_047305211.1
XP_047305212.1
XP_047305213.1
XP_047305214.1
XP_054204461.1
XP_054204462.1
XP_054204463.1
XP_054204464.1
XP_054204465.1
XP_054204466.1
XP_054204467.1
XP_054204468.1
XP_054204469.1
XP_054204470.1
XP_054204471.1
XP_054204472.1
XP_054204473.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014648.4NP_055463.1  E3 ubiquitin-protein ligase DZIP3

    See identical proteins and their annotated locations for NP_055463.1

    Status: VALIDATED

    Source sequence(s)
    AC092185, AC092693
    Consensus CDS
    CCDS2952.1
    UniProtKB/Swiss-Prot
    B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
    Related
    ENSP00000355028.3, ENST00000361582.8
    Conserved Domains (2) summary
    cd16460
    Location:11471188
    RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
    cl25732
    Location:675856
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    108589510..108694840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247917.4XP_005247974.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    See identical proteins and their annotated locations for XP_005247974.1

    UniProtKB/Swiss-Prot
    B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
    Conserved Domains (2) summary
    cd16460
    Location:11471188
    RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
    cl25732
    Location:675856
    SMC_N; RecF/RecN/SMC N terminal domain
  2. XM_005247914.5XP_005247971.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    See identical proteins and their annotated locations for XP_005247971.1

    UniProtKB/Swiss-Prot
    B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
    Conserved Domains (2) summary
    cd16460
    Location:11471188
    RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
    cl25732
    Location:675856
    SMC_N; RecF/RecN/SMC N terminal domain
  3. XM_047449256.1XP_047305212.1  E3 ubiquitin-protein ligase DZIP3 isoform X4

  4. XM_005247918.4XP_005247975.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    See identical proteins and their annotated locations for XP_005247975.1

    UniProtKB/Swiss-Prot
    B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
    Conserved Domains (2) summary
    cd16460
    Location:11471188
    RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
    cl25732
    Location:675856
    SMC_N; RecF/RecN/SMC N terminal domain
  5. XM_005247919.5XP_005247976.1  E3 ubiquitin-protein ligase DZIP3 isoform X4

    Conserved Domains (2) summary
    pfam12678
    Location:941982
    zf-rbx1; RING-H2 zinc finger
    pfam13639
    Location:942982
    zf-RING_2; Ring finger domain
  6. XM_047449254.1XP_047305210.1  E3 ubiquitin-protein ligase DZIP3 isoform X2

  7. XM_047449255.1XP_047305211.1  E3 ubiquitin-protein ligase DZIP3 isoform X3

  8. XM_047449257.1XP_047305213.1  E3 ubiquitin-protein ligase DZIP3 isoform X5

  9. XM_047449258.1XP_047305214.1  E3 ubiquitin-protein ligase DZIP3 isoform X6

    UniProtKB/TrEMBL
    C9J9M8
    Related
    ENSP00000418115.1, ENST00000479138.5
  10. XM_017007540.2XP_016863029.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    UniProtKB/Swiss-Prot
    B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
    Conserved Domains (2) summary
    cd16460
    Location:11471188
    RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
    cl25732
    Location:675856
    SMC_N; RecF/RecN/SMC N terminal domain
  11. XM_005247916.4XP_005247973.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    See identical proteins and their annotated locations for XP_005247973.1

    UniProtKB/Swiss-Prot
    B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
    Conserved Domains (2) summary
    cd16460
    Location:11471188
    RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
    cl25732
    Location:675856
    SMC_N; RecF/RecN/SMC N terminal domain
  12. XM_005247915.4XP_005247972.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    See identical proteins and their annotated locations for XP_005247972.1

    UniProtKB/Swiss-Prot
    B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
    Related
    ENSP00000419981.1, ENST00000463306.1
    Conserved Domains (2) summary
    cd16460
    Location:11471188
    RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
    cl25732
    Location:675856
    SMC_N; RecF/RecN/SMC N terminal domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    111309763..111415213
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348490.1XP_054204465.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    UniProtKB/Swiss-Prot
    B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
  2. XM_054348492.1XP_054204467.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    UniProtKB/Swiss-Prot
    B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
  3. XM_054348488.1XP_054204463.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    UniProtKB/Swiss-Prot
    B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
  4. XM_054348496.1XP_054204471.1  E3 ubiquitin-protein ligase DZIP3 isoform X4

  5. XM_054348495.1XP_054204470.1  E3 ubiquitin-protein ligase DZIP3 isoform X4

  6. XM_054348493.1XP_054204468.1  E3 ubiquitin-protein ligase DZIP3 isoform X2

  7. XM_054348494.1XP_054204469.1  E3 ubiquitin-protein ligase DZIP3 isoform X3

  8. XM_054348497.1XP_054204472.1  E3 ubiquitin-protein ligase DZIP3 isoform X5

  9. XM_054348498.1XP_054204473.1  E3 ubiquitin-protein ligase DZIP3 isoform X6

    UniProtKB/TrEMBL
    C9J9M8
  10. XM_054348489.1XP_054204464.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    UniProtKB/Swiss-Prot
    B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
  11. XM_054348486.1XP_054204461.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    UniProtKB/Swiss-Prot
    B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
  12. XM_054348487.1XP_054204462.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    UniProtKB/Swiss-Prot
    B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
  13. XM_054348491.1XP_054204466.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    UniProtKB/Swiss-Prot
    B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
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