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SLC35B1 solute carrier family 35 member B1 [ Homo sapiens (human) ]

Gene ID: 10237, updated on 10-Dec-2024

Summary

Official Symbol
SLC35B1provided by HGNC
Official Full Name
solute carrier family 35 member B1provided by HGNC
Primary source
HGNC:HGNC:20798
See related
Ensembl:ENSG00000121073 MIM:610790; AllianceGenome:HGNC:20798
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AXER; UGTREL1
Summary
This gene encodes a nucleotide sugar transporter which is a member of solute carrier family 35. The transporters in this family are highly conserved hydrophobic proteins with multiple transmembrane domains. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Expression
Ubiquitous expression in thyroid (RPKM 24.3), duodenum (RPKM 18.7) and 25 other tissues See more
Orthologs
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Genomic context

See SLC35B1 in Genome Data Viewer
Location:
17q21.33
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (49700943..49708197, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (50564044..50571286, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (47778305..47785326, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47654119-47654649 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47659009-47659562 Neighboring gene neurexophilin 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:47683760-47683957 Neighboring gene uncharacterized LOC107984999 Neighboring gene NANOG hESC enhancer GRCh37_chr17:47695165-47695679 Neighboring gene speckle type BTB/POZ protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12367 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12368 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:47784629-47785262 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:47785263-47785896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47796530-47797090 Neighboring gene family with sequence similarity 117 member A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12370 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8675 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47865191-47865964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12372 Neighboring gene SRP14 pseudogene 3 Neighboring gene lysine acetyltransferase 7

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of solute carrier family 35, member B1 (SLC35B1) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Interactions

General gene information

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in ADP transport  
involved_in ATP transport  
involved_in UDP-galactose transmembrane transport  
involved_in UDP-glucose transmembrane transport  
Component Evidence Code Pubs
is_active_in Golgi membrane  
is_active_in endoplasmic reticulum membrane  
located_in endoplasmic reticulum membrane PubMed 
located_in intracellular membrane-bounded organelle PubMed 

General protein information

Preferred Names
solute carrier family 35 member B1
Names
ATP/ADP exchanger ER
ATP/ADP exchanger in the ER membrane
UDP-galactose transporter related
UDP-galactose transporter-related protein 1
endoplasmic reticulum ATP/ADP translocase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278784.2NP_001265713.1  solute carrier family 35 member B1 isoform 2

    See identical proteins and their annotated locations for NP_001265713.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region and initiates translation at downstream start codon compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC015795, AI252816, AU309730, CX164572
    UniProtKB/TrEMBL
    D6R981
    Conserved Domains (1) summary
    pfam08449
    Location:18242
    UAA; UAA transporter family
  2. NM_005827.4NP_005818.3  solute carrier family 35 member B1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AC015795, AI252816, AU099388, BM476321, D87989
    Consensus CDS
    CCDS11552.3
    UniProtKB/Swiss-Prot
    B4DEC4, J3KQV4, P78383, Q96EW7
    Related
    ENSP00000240333.8, ENST00000240333.12
    Conserved Domains (1) summary
    pfam08449
    Location:16309
    UAA; UAA transporter family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    49700943..49708197 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524180.3XP_011522482.1  solute carrier family 35 member B1 isoform X3

    See identical proteins and their annotated locations for XP_011522482.1

    UniProtKB/TrEMBL
    D6R981
    Related
    ENSP00000423323.1, ENST00000503334.5
    Conserved Domains (1) summary
    pfam08449
    Location:18242
    UAA; UAA transporter family
  2. XM_011524179.3XP_011522481.1  solute carrier family 35 member B1 isoform X2

    Conserved Domains (2) summary
    pfam08449
    Location:53303
    UAA; UAA transporter family
    cl23754
    Location:199303
    EamA; EamA-like transporter family
  3. XM_006721632.4XP_006721695.1  solute carrier family 35 member B1 isoform X1

    Conserved Domains (1) summary
    pfam08449
    Location:53380
    UAA; UAA transporter family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    50564044..50571286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314671.1XP_054170646.1  solute carrier family 35 member B1 isoform X3

    UniProtKB/TrEMBL
    D6R981
  2. XM_054314670.1XP_054170645.1  solute carrier family 35 member B1 isoform X2

  3. XM_054314669.1XP_054170644.1  solute carrier family 35 member B1 isoform X1

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