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Gabrg2 gamma-aminobutyric acid type A receptor, subunit gamma 2 [ Mus musculus (house mouse) ]

Gene ID: 14406, updated on 9-Dec-2024

Summary

Official Symbol
Gabrg2provided by MGI
Official Full Name
gamma-aminobutyric acid type A receptor, subunit gamma 2provided by MGI
Primary source
MGI:MGI:95623
See related
Ensembl:ENSMUSG00000020436 AllianceGenome:MGI:95623
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
gamma2; GABAA-R; Gabrg-2
Summary
This gene encodes a gamma-aminobutyric acid (GABA)-A receptor subunit, which is a member of the ligand-gated ion channel family. GABA is the major inhibitory neurotransmitter in the adult central nervous system, and conversely exhibits an excitatory function during development. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. This gene encodes one of three gamma subunits in mammals, which contain the binding site for benzodiazepine drugs. Several mutations in this gene are associated with epileptic seizures, and genetic knockdown is associated with anxiety behavior. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Expression
Biased expression in cortex adult (RPKM 23.5), cerebellum adult (RPKM 23.4) and 5 other tissues See more
Orthologs
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Genomic context

See Gabrg2 in Genome Data Viewer
Location:
11 A5; 11 24.8 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (41801017..41891684, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (41910190..42000857, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene heat shock protein 1 (chaperonin), pseudogene 3 Neighboring gene basic transcription factor 3, pseudogene 7 Neighboring gene RIKEN cDNA A230004M16 gene Neighboring gene STARR-seq mESC enhancer starr_29241 Neighboring gene STARR-seq mESC enhancer starr_29242 Neighboring gene STARR-seq mESC enhancer starr_29243 Neighboring gene STARR-seq mESC enhancer starr_29244 Neighboring gene STARR-seq mESC enhancer starr_29245 Neighboring gene STARR-seq mESC enhancer starr_29247 Neighboring gene gamma-aminobutyric acid type A receptor subunit alpha 1 Neighboring gene gamma-aminobutyric acid type A receptor subunit alpha 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within adult behavior PubMed 
involved_in cellular response to histamine PubMed 
involved_in cellular response to zinc ion  
acts_upstream_of_or_within chemical synaptic transmission PubMed 
involved_in chloride transmembrane transport  
involved_in chloride transmembrane transport PubMed 
involved_in chloride transmembrane transport  
involved_in chloride transport  
involved_in gamma-aminobutyric acid signaling pathway  
acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway PubMed 
involved_in gamma-aminobutyric acid signaling pathway  
involved_in gamma-aminobutyric acid signaling pathway PubMed 
involved_in inhibitory synapse assembly  
involved_in inhibitory synapse assembly PubMed 
involved_in inhibitory synapse assembly  
acts_upstream_of_or_within post-embryonic development PubMed 
involved_in regulation of postsynaptic membrane potential  
involved_in regulation of postsynaptic membrane potential  
involved_in response to anesthetic  
involved_in synaptic transmission, GABAergic  
involved_in synaptic transmission, GABAergic  
involved_in synaptic transmission, GABAergic PubMed 
Items 1 - 20 of 22
Component Evidence Code Pubs
part_of GABA receptor complex  
part_of GABA-A receptor complex  
part_of GABA-A receptor complex PubMed 
part_of GABA-A receptor complex  
part_of GABA-A receptor complex  
is_active_in GABA-ergic synapse PubMed 
is_active_in GABA-ergic synapse PubMed 
is_active_in GABA-ergic synapse  
located_in axon PubMed 
located_in cell surface  
part_of chloride channel complex  
located_in cytoplasmic vesicle membrane  
located_in dendrite  
is_active_in dendrite membrane  
located_in dendrite membrane  
is_active_in glutamatergic synapse  
located_in inhibitory synapse  
located_in plasma membrane PubMed 
located_in plasma membrane  
is_active_in postsynapse  
is_active_in postsynaptic specialization membrane  
located_in postsynaptic specialization membrane  
Items 1 - 20 of 22

General protein information

Preferred Names
gamma-aminobutyric acid receptor subunit gamma-2
Names
GABAAR subunit gamma-2
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362655.1NP_001349584.1  gamma-aminobutyric acid receptor subunit gamma-2 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL645751, BX284629
    UniProtKB/TrEMBL
    Q8C8H5
    Conserved Domains (1) summary
    cl27321
    Location:50453
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
  2. NM_001362656.1NP_001349585.1  gamma-aminobutyric acid receptor subunit gamma-2 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AL645751, BX284629
    UniProtKB/TrEMBL
    Q8C8H5
    Conserved Domains (1) summary
    cl27321
    Location:49452
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
  3. NM_008073.4NP_032099.1  gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_032099.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1, also known as gamma 2L).
    Source sequence(s)
    AF233775, AL645751, BX284629
    Consensus CDS
    CCDS24551.1
    UniProtKB/Swiss-Prot
    P22723, Q91V50, Q91VA8
    UniProtKB/TrEMBL
    Q8C8H5
    Related
    ENSMUSP00000063812.3, ENSMUST00000070735.10
    Conserved Domains (2) summary
    TIGR00860
    Location:68471
    LIC; Cation transporter family protein
    cd19000
    Location:89270
    LGIC_ECD_GABAAR_G; extracellular domain of gamma-aminobutyric acid receptor subunit gamma
  4. NM_177408.7NP_803127.3  gamma-aminobutyric acid receptor subunit gamma-2 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2, also known as gamma 2S) is shorter, compared to isoform 1.
    Source sequence(s)
    AF233775, AK141129, AL645751, BX284629
    Consensus CDS
    CCDS24552.2
    UniProtKB/TrEMBL
    Q3UVW2
    Related
    ENSMUSP00000064739.5, ENSMUST00000070725.11
    Conserved Domains (3) summary
    TIGR00860
    Location:68463
    LIC; Cation transporter family protein
    pfam02931
    Location:68271
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:278460
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    41801017..41891684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156333.1XP_036012226.1  gamma-aminobutyric acid receptor subunit gamma-2 isoform X1

    UniProtKB/TrEMBL
    Q3UVW2
    Conserved Domains (2) summary
    TIGR00860
    Location:50445
    LIC; Cation transporter family protein
    cd19000
    Location:71252
    LGIC_ECD_GABAAR_G; extracellular domain of gamma-aminobutyric acid receptor subunit gamma
  2. XM_030245561.1XP_030101421.1  gamma-aminobutyric acid receptor subunit gamma-2 isoform X2

    UniProtKB/TrEMBL
    Q3UVW2
    Conserved Domains (2) summary
    TIGR00860
    Location:49444
    LIC; Cation transporter family protein
    cd19000
    Location:70251
    LGIC_ECD_GABAAR_G; extracellular domain of gamma-aminobutyric acid receptor subunit gamma
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