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Akap12 A-kinase anchoring protein 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83425, updated on 27-Dec-2024

Summary

Official Symbol
Akap12provided by RGD
Official Full Name
A-kinase anchoring protein 12provided by RGD
Primary source
RGD:70988
See related
EnsemblRapid:ENSRNOG00000019549 AllianceGenome:RGD:70988
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
AKAP12A; AKAP12B; AKAP12G
Summary
Predicted to enable adenylate cyclase binding activity. Involved in several processes, including cellular response to cytokine stimulus; hepatic stellate cell activation; and positive regulation of ERK1 and ERK2 cascade. Located in neuronal cell body. Biomarker of brain ischemia; liver cirrhosis; osteosarcoma; and sciatic neuropathy. Human ortholog(s) of this gene implicated in chronic kidney disease; colorectal carcinoma; and juvenile myelomonocytic leukemia. Orthologous to human AKAP12 (A-kinase anchoring protein 12). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Testes (RPKM 471.5), Lung (RPKM 241.4) and 8 other tissues See more
Orthologs
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Genomic context

See Akap12 in Genome Data Viewer
Location:
1q11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (43135515..43225245)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (40730123..40819863)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (40816130..40906582)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transcription factor BTF3-like Neighboring gene uncharacterized LOC134484990 Neighboring gene zinc finger and BTB domain containing 2 Neighboring gene zinc finger and BTB domain containing 2 like Neighboring gene required for meiotic nuclear division 1 homolog

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables adenylate cyclase binding  
enables calmodulin binding  
enables protein kinase A binding  
Process Evidence Code Pubs
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  
involved_in cellular response to interleukin-1 PubMed 
involved_in cellular response to tumor necrosis factor PubMed 
involved_in hepatic stellate cell activation PubMed 
involved_in modulation of chemical synaptic transmission  
involved_in negative regulation of vascular permeability PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
involved_in positive regulation of hepatic stellate cell migration PubMed 
involved_in positive regulation of oligodendrocyte apoptotic process PubMed 
involved_in positive regulation of protein kinase A signaling  
involved_in positive regulation of tumor necrosis factor production PubMed 
involved_in regulation of protein kinase A signaling  
involved_in regulation of protein kinase A signaling  
involved_in regulation of protein kinase C signaling  
involved_in response to electrical stimulus PubMed 
involved_in response to lipopolysaccharide PubMed 
involved_in signal transduction  
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse  
is_active_in cytoplasm  
located_in cytoskeleton  
located_in cytosol  
located_in cytosol  
located_in membrane  
located_in neuronal cell body PubMed 
located_in plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
A-kinase anchor protein 12
Names
A kinase (PRKA) anchor protein (gravin) 12
A kinase (PRKA) anchor protein 12
AKAP-12
SSeCKS, Gravin, AKAP250

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033653.1NP_001028825.1  A-kinase anchor protein 12 isoform beta

    See identical proteins and their annotated locations for NP_001028825.1

    Status: VALIDATED

    Source sequence(s)
    AY695057, BG664488
    UniProtKB/TrEMBL
    Q62766
    Related
    ENSRNOP00000070062.1, ENSRNOT00000083702.3
    Conserved Domains (1) summary
    pfam03832
    Location:513540
    WSK; WSK motif
  2. NM_057103.2NP_476444.2  A-kinase anchor protein 12 isoform alpha

    See identical proteins and their annotated locations for NP_476444.2

    Status: VALIDATED

    Source sequence(s)
    AY695056, BG664488
    UniProtKB/Swiss-Prot
    Q5QD49, Q5QD50, Q5QD51, Q9Z1F7
    UniProtKB/TrEMBL
    A6KIK8, Q62766
    Conserved Domains (1) summary
    pfam03832
    Location:593620
    WSK; WSK motif

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    43135515..43225245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006227847.5XP_006227909.1  A-kinase anchor protein 12 isoform X1

    See identical proteins and their annotated locations for XP_006227909.1

    UniProtKB/TrEMBL
    A0A8L2QEC9, A6KIK9, Q62766
    Conserved Domains (1) summary
    pfam03832
    Location:513540
    WSK; WSK motif
  2. XM_006227848.5XP_006227910.1  A-kinase anchor protein 12 isoform X2

    See identical proteins and their annotated locations for XP_006227910.1

    UniProtKB/TrEMBL
    A6KIL0, Q62766
    Related
    ENSRNOP00000026483.8, ENSRNOT00000026482.8
    Conserved Domains (1) summary
    pfam03832
    Location:488515
    WSK; WSK motif
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