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Psmb7 proteasome 20S subunit beta 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 85492, updated on 9-Dec-2024

Summary

Official Symbol
Psmb7provided by RGD
Official Full Name
proteasome 20S subunit beta 7provided by RGD
Primary source
RGD:621093
See related
EnsemblRapid:ENSRNOG00000011732 AllianceGenome:RGD:621093
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable endopeptidase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in nuclear body. Predicted to be part of proteasome core complex, beta-subunit complex. Predicted to be active in cytosol and nucleus. Orthologous to human PSMB7 (proteasome 20S subunit beta 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Muscle (RPKM 1329.7), Heart (RPKM 1061.7) and 9 other tissues See more
Orthologs
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Genomic context

See Psmb7 in Genome Data Viewer
Location:
3q12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (42767500..42827470, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (22357777..22417748, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (22890072..22951718, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene double PHD fingers 3 like 1 Neighboring gene uncharacterized LOC120101538 Neighboring gene NIMA-related kinase 6 Neighboring gene ALG11, alpha-1,2-mannosyltransferase, pseudogene 3 Neighboring gene ribosomal protein S20, pseudogene 10

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables endopeptidase activity  
enables threonine-type endopeptidase activity  
Component Evidence Code Pubs
is_active_in cytoplasm  
is_active_in cytosol  
located_in cytosol  
located_in cytosol  
located_in nuclear body  
located_in nuclear body  
located_in nucleoplasm  
is_active_in nucleus  
is_active_in nucleus  
part_of proteasome complex  
part_of proteasome core complex  
part_of proteasome core complex  
part_of proteasome core complex  
part_of proteasome core complex, beta-subunit complex  
part_of proteasome core complex, beta-subunit complex  

General protein information

Preferred Names
proteasome subunit beta type-7
Names
beta-2
macropain chain Z
multicatalytic endopeptidase complex chain Z
proteasome (prosome, macropain) subunit, beta type 7
proteasome beta 7 subunit
proteasome subunit Z
proteasome subunit beta 7
proteasome subunit beta-2
NP_445984.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053532.1NP_445984.1  proteasome subunit beta type-7

    See identical proteins and their annotated locations for NP_445984.1

    Status: PROVISIONAL

    Source sequence(s)
    AF285103
    UniProtKB/Swiss-Prot
    Q9JHW0
    UniProtKB/TrEMBL
    A0A8L2R849
    Related
    ENSRNOP00000073989.2, ENSRNOT00000085981.3
    Conserved Domains (2) summary
    cd03763
    Location:44232
    proteasome_beta_type_7; proteasome beta type-7 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
    pfam12465
    Location:236271
    Pr_beta_C; Proteasome beta subunits C terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    42767500..42827470 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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