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    Mboat1 membrane bound O-acyltransferase domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 218121, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mboat1provided by MGI
    Official Full Name
    membrane bound O-acyltransferase domain containing 1provided by MGI
    Primary source
    MGI:MGI:2387184
    See related
    Ensembl:ENSMUSG00000038732 AllianceGenome:MGI:2387184
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LPEAT; LPSAT; Oact1; LPEAT1; Moact1; LPLAT 1; 9130215M02Rik
    Summary
    Enables 1-acylglycerophosphoethanolamine O-acyltransferase activity. Involved in phosphatidylethanolamine acyl-chain remodeling; phospholipid biosynthetic process; and regulation of neuron projection development. Located in endoplasmic reticulum membrane. Is expressed in several structures, including central nervous system; gut; integumental system; respiratory system; and urinary system. Orthologous to human MBOAT1 (membrane bound O-acyltransferase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in colon adult (RPKM 26.9), stomach adult (RPKM 19.8) and 11 other tissues See more
    Orthologs
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    Genomic context

    See Mboat1 in Genome Data Viewer
    Location:
    13 A3.2; 13 13.14 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (30320499..30430677)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (30136451..30246694)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene E2F transcription factor 3 Neighboring gene STARR-positive B cell enhancer ABC_E9871 Neighboring gene STARR-positive B cell enhancer ABC_E211 Neighboring gene STARR-seq mESC enhancer starr_34059 Neighboring gene STARR-seq mESC enhancer starr_34060 Neighboring gene predicted gene, 40860 Neighboring gene STARR-seq mESC enhancer starr_34062 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:30176986-30177169 Neighboring gene STARR-seq mESC enhancer starr_34063 Neighboring gene predicted gene, 23206 Neighboring gene predicted gene, 40869 Neighboring gene non-POU-domain-containing, octamer binding protein pseudogene Neighboring gene STARR-seq mESC enhancer starr_34065 Neighboring gene predicted gene, 40863 Neighboring gene predicted gene, 53782 Neighboring gene STARR-seq mESC enhancer starr_34066 Neighboring gene angiotensin II receptor, type 1a Neighboring gene STARR-seq mESC enhancer starr_34067 Neighboring gene STARR-seq mESC enhancer starr_34068 Neighboring gene ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    General gene information

    Clone Names

    • MGC38410

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane PubMed 
    is_active_in membrane  

    General protein information

    Preferred Names
    lysophospholipid acyltransferase 1
    Names
    1-acylglycerophosphocholine O-acyltransferase
    1-acylglycerophosphoethanolamine O-acyltransferase
    1-acylglycerophosphoethanolamine O-acyltransferase MBOAT1
    1-acylglycerophosphoserine O-acyltransferase
    1-acylglycerophosphoserine O-acyltransferase MBOAT1
    LPE acyltransferase 1
    O-acyltransferase (membrane bound) domain containing 1
    O-acyltransferase domain-containing protein 1
    lyso-PE acyltransferase
    lyso-PS acyltransferase
    lysophosphatidylethanolamine acyltransferase
    lysophosphatidylethanolamine acyltransferase 1
    lysophosphatidylserine acyltransferase
    membrane bound O-acyl transferase family, member 1
    membrane-bound O-acyltransferase domain-containing protein 1
    NP_001405885.1
    NP_001405886.1
    NP_001405887.1
    NP_001405888.1
    NP_705774.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418956.1NP_001405885.1  lysophospholipid acyltransferase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL450321, AL645749
    2. NM_001418957.1NP_001405886.1  lysophospholipid acyltransferase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL450321, AL645749
    3. NM_001418958.1NP_001405887.1  lysophospholipid acyltransferase 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL450321, AL645749
    4. NM_001418959.1NP_001405888.1  lysophospholipid acyltransferase 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL450321, AL645749
    5. NM_153546.5NP_705774.1  lysophospholipid acyltransferase 1 isoform 1

      See identical proteins and their annotated locations for NP_705774.1

      Status: VALIDATED

      Source sequence(s)
      AL450321, AL645749
      Consensus CDS
      CCDS26414.1
      UniProtKB/Swiss-Prot
      A9EDS0, Q8BH98, Q8R3T2
      Related
      ENSMUSP00000045441.9, ENSMUST00000047311.16
      Conserved Domains (1) summary
      cl00738
      Location:21458
      MBOAT; MBOAT, membrane-bound O-acyltransferase family

    RNA

    1. NR_184863.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL450321, AL645749

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      30320499..30430677
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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