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    RAB21 RAB21, member RAS oncogene family [ Homo sapiens (human) ]

    Gene ID: 23011, updated on 10-Dec-2024

    Summary

    Official Symbol
    RAB21provided by HGNC
    Official Full Name
    RAB21, member RAS oncogene familyprovided by HGNC
    Primary source
    HGNC:HGNC:18263
    See related
    Ensembl:ENSG00000080371 MIM:612398; AllianceGenome:HGNC:18263
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene belongs to the Rab family of monomeric GTPases, which are involved in the control of cellular membrane traffic. The encoded protein plays a role in the targeted trafficking of integrins via its association with integrin alpha tails. As a consequence, the encoded protein is involved in the regulation of cell adhesion and migration. Expression of this gene is associated with a poor prognosis for glioma patients. This gene is downregulated by the tumor suppressor miR-200b, and miRNA-200b is itself downregulated in glioma tissues. [provided by RefSeq, Nov 2015]
    Expression
    Ubiquitous expression in kidney (RPKM 10.9), adrenal (RPKM 10.2) and 25 other tissues See more
    Orthologs
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    Genomic context

    See RAB21 in Genome Data Viewer
    Location:
    12q21.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (71754863..71800286)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (71732345..71777766)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (72148643..72194066)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4658 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:72080194-72080409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6661 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6662 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:72101517-72101722 Neighboring gene uncharacterized LOC107984530 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:72103459-72104658 Neighboring gene transmembrane protein 19 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:72119048-72120247 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:72141645-72141854 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6663 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4659 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6664 Neighboring gene TBC1 domain family member 15 Neighboring gene MRS2 pseudogene 2 Neighboring gene MPRA-validated peak1826 silencer Neighboring gene Sharpr-MPRA regulatory region 15327 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:72332491-72332790 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:72342997-72343855 Neighboring gene NANOG hESC enhancer GRCh37_chr12:72352432-72352933 Neighboring gene tryptophan hydroxylase 2 Neighboring gene Sharpr-MPRA regulatory region 15256

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • KIAA0118

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GDP binding PubMed 
    enables GTP binding PubMed 
    enables GTP binding PubMed 
    enables GTPase activity  
    enables GTPase activity PubMed 
    enables protein binding PubMed 
    Component Evidence Code Pubs
    located_in Golgi cisterna membrane PubMed 
    located_in Golgi membrane  
    located_in axon cytoplasm  
    located_in cleavage furrow  
    located_in cytoplasmic side of early endosome membrane PubMed 
    located_in cytoplasmic side of plasma membrane PubMed 
    located_in cytosol  
    is_active_in early endosome  
    located_in early endosome membrane  
    is_active_in endomembrane system  
    located_in endoplasmic reticulum membrane  
    located_in endosome  
    located_in extracellular exosome PubMed 
    located_in focal adhesion PubMed 
    located_in synapse  
    located_in trans-Golgi network PubMed 
    located_in vesicle membrane PubMed 

    General protein information

    Preferred Names
    ras-related protein Rab-21
    Names
    GTP-binding protein RAB21
    NP_055814.1
    XP_047284497.1
    XP_054227438.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014999.4NP_055814.1  ras-related protein Rab-21

      See identical proteins and their annotated locations for NP_055814.1

      Status: REVIEWED

      Source sequence(s)
      AC089984, AF091035, CB990575
      Consensus CDS
      CCDS9003.1
      UniProtKB/Swiss-Prot
      Q14466, Q569H3, Q9UL25
      Related
      ENSP00000261263.3, ENST00000261263.5
      Conserved Domains (2) summary
      cd04123
      Location:20181
      Rab21; Rab GTPase family 21 (Rab21)
      pfam00071
      Location:21182
      Ras; Ras family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      71754863..71800286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428541.1XP_047284497.1  ras-related protein Rab-21 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      71732345..71777766
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054371463.1XP_054227438.1  ras-related protein Rab-21 isoform X1

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