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    Tmprss11b transmembrane protease, serine 11B [ Mus musculus (house mouse) ]

    Gene ID: 319875, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tmprss11bprovided by MGI
    Official Full Name
    transmembrane protease, serine 11Bprovided by MGI
    Primary source
    MGI:MGI:2442893
    See related
    Ensembl:ENSMUSG00000035861 AllianceGenome:MGI:2442893
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmprss11bnl; 9930019B18Rik
    Summary
    Predicted to enable serine-type peptidase activity. Predicted to be involved in proteolysis. Predicted to be located in plasma membrane. Is expressed in ductus deferens; prostate gland; and testis. Orthologous to human TMPRSS11B (transmembrane serine protease 11B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

    See Tmprss11b in Genome Data Viewer
    Location:
    5 E1; 5 43.56 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (86806326..86824221, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (86659522..86676298, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene transmembrane protease, serine 11g Neighboring gene transmembrane protease, serine 11f Neighboring gene transmembrane protease, serine 11e Neighboring gene STARR-seq mESC enhancer starr_13551 Neighboring gene YTH domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Targeted (3) 

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity  
    enables serine-type peptidase activity  
    enables serine-type peptidase activity  
    Process Evidence Code Pubs
    involved_in proteolysis  
    Component Evidence Code Pubs
    located_in extracellular region  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    transmembrane protease serine 11B-like protein
    Names
    airway trypsin-like protease 5
    transmembrane protease, serine 11b N terminal like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177024.5NP_795998.2  transmembrane protease serine 11B-like protein

      See identical proteins and their annotated locations for NP_795998.2

      Status: VALIDATED

      Source sequence(s)
      AC103930
      Consensus CDS
      CCDS39126.1
      UniProtKB/Swiss-Prot
      Q14C59, Q8BZ13, Q8BZ30
      Related
      ENSMUSP00000042406.7, ENSMUST00000038448.7
      Conserved Domains (3) summary
      smart00020
      Location:184410
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:185413
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam01390
      Location:46140
      SEA; SEA domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      86806326..86824221 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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