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    Fen1 flap structure specific endonuclease 1 [ Mus musculus (house mouse) ]

    Gene ID: 14156, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fen1provided by MGI
    Official Full Name
    flap structure specific endonuclease 1provided by MGI
    Primary source
    MGI:MGI:102779
    See related
    Ensembl:ENSMUSG00000024742 AllianceGenome:MGI:102779
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FEN-1
    Summary
    Enables DNA binding activity; metal ion binding activity; and nuclease activity. Acts upstream of or within DNA repair and DNA replication. Predicted to be located in mitochondrion; nucleolus; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Predicted to colocalize with chromosome, telomeric region. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human FEN1 (flap structure-specific endonuclease 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver E14 (RPKM 32.5), liver E14.5 (RPKM 31.6) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Fen1 in Genome Data Viewer
    Location:
    19 A; 19 6.54 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10176496..10181757, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10199132..10204393, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene vesicle-associated membrane protein 3 pseudogene Neighboring gene fatty acid desaturase 1 Neighboring gene microRNA 6993 Neighboring gene STARR-positive B cell enhancer ABC_E11020 Neighboring gene transmembrane protein 258 Neighboring gene myelin regulatory factor Neighboring gene diacylglycerol lipase, alpha Neighboring gene STARR-seq mESC enhancer starr_45549 Neighboring gene predicted gene, 30042

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (10)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5'-3' exonuclease activity  
    enables 5'-3' exonuclease activity  
    enables 5'-3' exonuclease activity  
    enables 5'-flap endonuclease activity  
    enables 5'-flap endonuclease activity  
    enables 5'-flap endonuclease activity  
    enables DNA binding PubMed 
    enables DNA binding  
    enables RNA-DNA hybrid ribonuclease activity  
    enables RNA-DNA hybrid ribonuclease activity  
    enables exonuclease activity PubMed 
    enables flap endonuclease activity PubMed 
    enables flap endonuclease activity  
    enables magnesium ion binding  
    enables magnesium ion binding PubMed 
    enables manganese ion binding  
    enables manganese ion binding PubMed 
    Component Evidence Code Pubs
    colocalizes_with chromosome, telomeric region  
    located_in mitochondrion  
    located_in mitochondrion  
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in nucleus PubMed 
    part_of protein-containing complex PubMed 

    General protein information

    Preferred Names
    flap endonuclease 1
    NP_001258543.1
    NP_001258544.1
    NP_001397211.1
    NP_032025.2
    XP_006526726.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271614.2NP_001258543.1  flap endonuclease 1

      See identical proteins and their annotated locations for NP_001258543.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC132148
      Consensus CDS
      CCDS29573.1
      UniProtKB/TrEMBL
      Q3TGH6, Q8C952, Q8R069, Q91Z50
      Related
      ENSMUSP00000119221.2, ENSMUST00000142241.2
      Conserved Domains (1) summary
      PTZ00217
      Location:1359
      PTZ00217; flap endonuclease-1; Provisional
    2. NM_001271615.3NP_001258544.1  flap endonuclease 1

      See identical proteins and their annotated locations for NP_001258544.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC132148
      Consensus CDS
      CCDS29573.1
      UniProtKB/TrEMBL
      Q3TGH6, Q8C952, Q8R069, Q91Z50
      Conserved Domains (1) summary
      PTZ00217
      Location:1359
      PTZ00217; flap endonuclease-1; Provisional
    3. NM_001410282.1NP_001397211.1  flap endonuclease 1

      Status: VALIDATED

      Source sequence(s)
      AC132148
      UniProtKB/TrEMBL
      Q3TGH6, Q8C952, Q8R069, Q91Z50
      Related
      ENSMUSP00000025651.5, ENSMUST00000025651.6
    4. NM_007999.6NP_032025.2  flap endonuclease 1

      See identical proteins and their annotated locations for NP_032025.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC132148
      Consensus CDS
      CCDS29573.1
      UniProtKB/TrEMBL
      Q3TGH6, Q8C952, Q8R069, Q91Z50
      Related
      ENSMUSP00000117246.2, ENSMUST00000156291.2
      Conserved Domains (1) summary
      PTZ00217
      Location:1359
      PTZ00217; flap endonuclease-1; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      10176496..10181757 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526663.4XP_006526726.1  flap endonuclease 1 isoform X1

      See identical proteins and their annotated locations for XP_006526726.1

      UniProtKB/TrEMBL
      Q3TGH6, Q8C952, Q8R069, Q91Z50
      Conserved Domains (1) summary
      PTZ00217
      Location:1359
      PTZ00217; flap endonuclease-1; Provisional
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