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Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) [ Mus musculus (house mouse) ]

Gene ID: 22229, updated on 9-Dec-2024

Summary

Official Symbol
Ucp3provided by MGI
Official Full Name
uncoupling protein 3 (mitochondrial, proton carrier)provided by MGI
Primary source
MGI:MGI:1099787
See related
Ensembl:ENSMUSG00000032942 AllianceGenome:MGI:1099787
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UCP-3; Slc25a9
Summary
Enables oxidative phosphorylation uncoupler activity and proton transmembrane transporter activity. Involved in lipid hydroperoxide transport and proton transmembrane transport. Acts upstream of or within fatty acid metabolic process and response to superoxide. Located in mitochondrial inner membrane. Is expressed in adipose tissue; heart; skeletal muscle; and telencephalon. Human ortholog(s) of this gene implicated in coronary restenosis; diabetic neuropathy; glucose metabolism disease (multiple); and obesity. Orthologous to human UCP3 (uncoupling protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in mammary gland adult (RPKM 11.6), heart adult (RPKM 10.8) and 10 other tissues See more
Orthologs
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Genomic context

See Ucp3 in Genome Data Viewer
Location:
7 E2; 7 54.36 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (100122198..100135639)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (100472991..100486432)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase methylesterase 1 Neighboring gene STARR-positive B cell enhancer ABC_E2243 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:107520817-107520926 Neighboring gene C2 calcium-dependent domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_19668 Neighboring gene predicted gene 10603 Neighboring gene STARR-positive B cell enhancer mm9_chr7:107641658-107641958 Neighboring gene STARR-positive B cell enhancer ABC_E2244 Neighboring gene STARR-seq mESC enhancer starr_19669 Neighboring gene uncoupling protein 2 (mitochondrial, proton carrier) Neighboring gene DnaJ heat shock protein family (Hsp40) member B13 Neighboring gene ribosomal protein S8 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (3)  1 citation

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in adaptive thermogenesis  
involved_in cellular response to hormone stimulus  
acts_upstream_of_or_within fatty acid metabolic process PubMed 
involved_in lipid hydroperoxide transport PubMed 
involved_in mitochondrial transmembrane transport  
involved_in proton transmembrane transport PubMed 
involved_in proton transmembrane transport  
involved_in response to activity  
involved_in response to cold  
involved_in response to fenofibrate  
involved_in response to glucocorticoid  
involved_in response to hypoxia  
involved_in response to hypoxia  
involved_in response to insulin  
involved_in response to nutrient  
acts_upstream_of_or_within response to superoxide PubMed 
involved_in response to superoxide  
Component Evidence Code Pubs
located_in mitochondrial inner membrane PubMed 
located_in mitochondrion PubMed 
located_in mitochondrion PubMed 

General protein information

Preferred Names
putative mitochondrial transporter UCP3
Names
mitochondrial uncoupling protein 3
solute carrier family 25 member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009464.3NP_033490.1  putative mitochondrial transporter UCP3

    See identical proteins and their annotated locations for NP_033490.1

    Status: VALIDATED

    Source sequence(s)
    AC117215
    Consensus CDS
    CCDS21497.1
    UniProtKB/Swiss-Prot
    O88293, P56501
    UniProtKB/TrEMBL
    B2RTM2
    Related
    ENSMUSP00000032958.8, ENSMUST00000032958.14
    Conserved Domains (2) summary
    PTZ00169
    Location:13298
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:109206
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    100122198..100135639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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