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    GCC2 GRIP and coiled-coil domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 9648, updated on 10-Dec-2024

    Summary

    Official Symbol
    GCC2provided by HGNC
    Official Full Name
    GRIP and coiled-coil domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:23218
    See related
    Ensembl:ENSG00000135968 MIM:612711; AllianceGenome:HGNC:23218
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    REN53; GCC185; RANBP2L4
    Summary
    The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
    Expression
    Ubiquitous expression in gall bladder (RPKM 11.9), thyroid (RPKM 11.7) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See GCC2 in Genome Data Viewer
    Location:
    2q12.3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (108449206..108509415)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (108909826..108970093)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (109065662..109125871)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene sulfotransferase family 1C member 4 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:109019914-109020414 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:109020415-109020915 Neighboring gene small integral membrane protein 12 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr2:109064602-109065584 and GRCh37_chr2:109065585-109066566 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:109066652-109067152 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:109067153-109067653 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16343 Neighboring gene 2q12.3 distal recombination region Neighboring gene GCC2 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 7983 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11849 Neighboring gene LIM zinc finger domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16344 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:109191556-109192512 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16345 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:109210352-109211551 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16347 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16348 Neighboring gene NANOG hESC enhancer GRCh37_chr2:109225689-109226190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16349 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:109252737-109253311 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16350 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:109271409-109272023 Neighboring gene Sharpr-MPRA regulatory region 6630 Neighboring gene LIMS1 antisense RNA 1 Neighboring gene cytochrome c oxidase subunit 7B, mitochondrial-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef binds GCC2 (GCC185); the N-terminal EEEE65 acidic domain of Nef as the key region for interaction PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • KIAA0336

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding PubMed 
    enables protein binding PubMed 
    enables small GTPase binding  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus  
    located_in Golgi apparatus PubMed 
    located_in cytosol  
    located_in membrane PubMed 
    located_in nucleoplasm  
    located_in trans-Golgi network PubMed 

    General protein information

    Preferred Names
    GRIP and coiled-coil domain-containing protein 2
    Names
    185 kDa Golgi coiled-coil protein
    CLL-associated antigen KW-11
    CTCL tumor antigen se1-1
    GCC protein, 185-kD
    Golgi coiled-coil protein GCC185
    Ran-binding protein 2-like 4
    renal carcinoma antigen NY-REN-53

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410194.1NP_001397123.1  GRIP and coiled-coil domain-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC012487, AC068941
      UniProtKB/TrEMBL
      A0A8I5KW38, A0A8I5QJB7
      Related
      ENSP00000508981.1, ENST00000685519.1
    2. NM_181453.4NP_852118.2  GRIP and coiled-coil domain-containing protein 2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
      Source sequence(s)
      AC012487, AC068941
      Consensus CDS
      CCDS33268.1
      UniProtKB/Swiss-Prot
      A6H8X8, O15045, Q4ZG46, Q8IWJ2, Q8TDH3, Q9H2G8
      UniProtKB/TrEMBL
      A0A8I5KW38
      Related
      ENSP00000307939.5, ENST00000309863.11
      Conserved Domains (4) summary
      COG1196
      Location:41953
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:7001478
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam16704
      Location:15481612
      Rab_bind; Rab binding domain
      pfam01465
      Location:16131656
      GRIP; GRIP domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      108449206..108509415
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006712870.4XP_006712933.1  GRIP and coiled-coil domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KW38
      Conserved Domains (4) summary
      COG1196
      Location:44956
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:7031481
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01465
      Location:16171659
      GRIP; GRIP domain
      pfam16704
      Location:15511615
      Rab_bind; Rab binding domain
    2. XM_006712871.2XP_006712934.1  GRIP and coiled-coil domain-containing protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006712934.1

      UniProtKB/TrEMBL
      A0A8I5KW38, A0A8I5QJB7
      Conserved Domains (4) summary
      COG1196
      Location:17852
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:5991377
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01465
      Location:15131555
      GRIP; GRIP domain
      pfam16704
      Location:14471511
      Rab_bind; Rab binding domain
    3. XM_047446447.1XP_047302403.1  GRIP and coiled-coil domain-containing protein 2 isoform X3

    4. XM_047446448.1XP_047302404.1  GRIP and coiled-coil domain-containing protein 2 isoform X4

    5. XM_006712872.4XP_006712935.1  GRIP and coiled-coil domain-containing protein 2 isoform X5

      UniProtKB/TrEMBL
      B8ZZW2
      Conserved Domains (1) summary
      COG1196
      Location:44956
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    6. XM_047446449.1XP_047302405.1  GRIP and coiled-coil domain-containing protein 2 isoform X6

      UniProtKB/TrEMBL
      B8ZZW2
      Related
      ENSP00000386997.1, ENST00000409896.1

    RNA

    1. XR_923067.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      108909826..108970093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344670.1XP_054200645.1  GRIP and coiled-coil domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KW38
    2. XM_054344671.1XP_054200646.1  GRIP and coiled-coil domain-containing protein 2 isoform X3

    3. XM_054344672.1XP_054200647.1  GRIP and coiled-coil domain-containing protein 2 isoform X4

    4. XM_054344673.1XP_054200648.1  GRIP and coiled-coil domain-containing protein 2 isoform X5

      UniProtKB/TrEMBL
      B8ZZW2
    5. XM_054344674.1XP_054200649.1  GRIP and coiled-coil domain-containing protein 2 isoform X6

      UniProtKB/TrEMBL
      B8ZZW2

    RNA

    1. XR_008486606.1 RNA Sequence

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