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Cdh7 cadherin 7, type 2 [ Mus musculus (house mouse) ]

Gene ID: 241201, updated on 9-Dec-2024

Summary

Official Symbol
Cdh7provided by MGI
Official Full Name
cadherin 7, type 2provided by MGI
Primary source
MGI:MGI:2442792
See related
Ensembl:ENSMUSG00000026312 AllianceGenome:MGI:2442792
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CDH7L1; 9330156F07Rik
Summary
This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene is located adjacent to a related cadherin gene on chromosome 1. [provided by RefSeq, Oct 2015]
Expression
Biased expression in cerebellum adult (RPKM 1.6), CNS E18 (RPKM 1.0) and 5 other tissues See more
Orthologs
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Genomic context

See Cdh7 in Genome Data Viewer
Location:
1 E2.1; 1 50.73 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (109909967..110073002)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (109982237..110145272)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22159 Neighboring gene heat shock protein 8 pseudogene Neighboring gene predicted gene, 41930 Neighboring gene STARR-seq mESC enhancer starr_01887 Neighboring gene polo-like kinase 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Clone Names

  • MGC118246

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-catenin binding  
enables cadherin binding  
enables calcium ion binding  
Process Evidence Code Pubs
involved_in adherens junction organization  
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  
involved_in cell migration  
involved_in cell morphogenesis  
involved_in cell-cell adhesion mediated by cadherin  
involved_in cell-cell junction assembly  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules  
Component Evidence Code Pubs
is_active_in adherens junction  
part_of catenin complex  
located_in plasma membrane  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316743.1NP_001303672.1  cadherin-7 isoform 1 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AC101794, AC166749, AK046426, BC083189, CJ130526
    Consensus CDS
    CCDS15221.1
    UniProtKB/Swiss-Prot
    Q3UVE2, Q67G09, Q8BM92
    UniProtKB/TrEMBL
    B2RUF4
    Related
    ENSMUSP00000027542.7, ENSMUST00000027542.13
    Conserved Domains (3) summary
    cd11304
    Location:157258
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:73151
    CA; Cadherin repeats
    pfam01049
    Location:631779
    Cadherin_C; Cadherin cytoplasmic region
  2. NM_001316744.1NP_001303673.1  cadherin-7 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC101794, AC166749, AK046426, BC083189
    UniProtKB/TrEMBL
    B2RUF4
    Conserved Domains (3) summary
    cd11304
    Location:99200
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:1593
    CA; Cadherin repeats
    pfam01049
    Location:581719
    Cadherin_C; Cadherin cytoplasmic region
  3. NM_172853.3NP_766441.1  cadherin-7 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_766441.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AC101794, AK046426, BC083189
    Consensus CDS
    CCDS15221.1
    UniProtKB/Swiss-Prot
    Q3UVE2, Q67G09, Q8BM92
    UniProtKB/TrEMBL
    B2RUF4
    Related
    ENSMUSP00000129715.2, ENSMUST00000172005.8
    Conserved Domains (3) summary
    cd11304
    Location:157258
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:73151
    CA; Cadherin repeats
    pfam01049
    Location:631779
    Cadherin_C; Cadherin cytoplasmic region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    109909967..110073002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320693.2XP_017176182.1  cadherin-7 isoform X1

    UniProtKB/Swiss-Prot
    Q3UVE2, Q67G09, Q8BM92
    UniProtKB/TrEMBL
    B2RUF4
    Conserved Domains (3) summary
    cd11304
    Location:157258
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:73151
    CA; Cadherin repeats
    pfam01049
    Location:631779
    Cadherin_C; Cadherin cytoplasmic region
  2. XM_006529608.3XP_006529671.1  cadherin-7 isoform X1

    See identical proteins and their annotated locations for XP_006529671.1

    UniProtKB/Swiss-Prot
    Q3UVE2, Q67G09, Q8BM92
    UniProtKB/TrEMBL
    B2RUF4
    Conserved Domains (3) summary
    cd11304
    Location:157258
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:73151
    CA; Cadherin repeats
    pfam01049
    Location:631779
    Cadherin_C; Cadherin cytoplasmic region
  3. XM_006529600.3XP_006529663.1  cadherin-7 isoform X1

    See identical proteins and their annotated locations for XP_006529663.1

    UniProtKB/Swiss-Prot
    Q3UVE2, Q67G09, Q8BM92
    UniProtKB/TrEMBL
    B2RUF4
    Conserved Domains (3) summary
    cd11304
    Location:157258
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:73151
    CA; Cadherin repeats
    pfam01049
    Location:631779
    Cadherin_C; Cadherin cytoplasmic region
  4. XM_036165096.1XP_036020989.1  cadherin-7 isoform X2

    UniProtKB/TrEMBL
    B2RUF4
    Conserved Domains (3) summary
    cd11304
    Location:157258
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:73151
    CA; Cadherin repeats
    pfam01049
    Location:626774
    Cadherin_C; Cadherin cytoplasmic region
  5. XM_017320698.1XP_017176187.1  cadherin-7 isoform X1

    UniProtKB/Swiss-Prot
    Q3UVE2, Q67G09, Q8BM92
    UniProtKB/TrEMBL
    B2RUF4
    Conserved Domains (3) summary
    cd11304
    Location:157258
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:73151
    CA; Cadherin repeats
    pfam01049
    Location:631779
    Cadherin_C; Cadherin cytoplasmic region
  6. XM_017320699.1XP_017176188.1  cadherin-7 isoform X1

    UniProtKB/Swiss-Prot
    Q3UVE2, Q67G09, Q8BM92
    UniProtKB/TrEMBL
    B2RUF4
    Conserved Domains (3) summary
    cd11304
    Location:157258
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:73151
    CA; Cadherin repeats
    pfam01049
    Location:631779
    Cadherin_C; Cadherin cytoplasmic region
  7. XM_036165091.1XP_036020984.1  cadherin-7 isoform X1

    UniProtKB/Swiss-Prot
    Q3UVE2, Q67G09, Q8BM92
    UniProtKB/TrEMBL
    B2RUF4
    Conserved Domains (3) summary
    cd11304
    Location:157258
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:73151
    CA; Cadherin repeats
    pfam01049
    Location:631779
    Cadherin_C; Cadherin cytoplasmic region
  8. XM_017320701.1XP_017176190.1  cadherin-7 isoform X1

    UniProtKB/Swiss-Prot
    Q3UVE2, Q67G09, Q8BM92
    UniProtKB/TrEMBL
    B2RUF4
    Conserved Domains (3) summary
    cd11304
    Location:157258
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:73151
    CA; Cadherin repeats
    pfam01049
    Location:631779
    Cadherin_C; Cadherin cytoplasmic region
  9. XM_006529601.3XP_006529664.1  cadherin-7 isoform X1

    See identical proteins and their annotated locations for XP_006529664.1

    UniProtKB/Swiss-Prot
    Q3UVE2, Q67G09, Q8BM92
    UniProtKB/TrEMBL
    B2RUF4
    Conserved Domains (3) summary
    cd11304
    Location:157258
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:73151
    CA; Cadherin repeats
    pfam01049
    Location:631779
    Cadherin_C; Cadherin cytoplasmic region
  10. XM_011248006.2XP_011246308.1  cadherin-7 isoform X1

    See identical proteins and their annotated locations for XP_011246308.1

    UniProtKB/Swiss-Prot
    Q3UVE2, Q67G09, Q8BM92
    UniProtKB/TrEMBL
    B2RUF4
    Conserved Domains (3) summary
    cd11304
    Location:157258
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:73151
    CA; Cadherin repeats
    pfam01049
    Location:631779
    Cadherin_C; Cadherin cytoplasmic region
  11. XM_006529609.3XP_006529672.1  cadherin-7 isoform X1

    See identical proteins and their annotated locations for XP_006529672.1

    UniProtKB/Swiss-Prot
    Q3UVE2, Q67G09, Q8BM92
    UniProtKB/TrEMBL
    B2RUF4
    Conserved Domains (3) summary
    cd11304
    Location:157258
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:73151
    CA; Cadherin repeats
    pfam01049
    Location:631779
    Cadherin_C; Cadherin cytoplasmic region
  12. XM_017320706.2XP_017176195.1  cadherin-7 isoform X3

    Conserved Domains (2) summary
    cd11304
    Location:157258
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:73151
    CA; Cadherin repeats
  13. XM_017320703.2XP_017176192.1  cadherin-7 isoform X1

    UniProtKB/Swiss-Prot
    Q3UVE2, Q67G09, Q8BM92
    UniProtKB/TrEMBL
    B2RUF4
    Conserved Domains (3) summary
    cd11304
    Location:157258
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:73151
    CA; Cadherin repeats
    pfam01049
    Location:631779
    Cadherin_C; Cadherin cytoplasmic region
  14. XM_006529610.4XP_006529673.1  cadherin-7 isoform X1

    See identical proteins and their annotated locations for XP_006529673.1

    UniProtKB/Swiss-Prot
    Q3UVE2, Q67G09, Q8BM92
    UniProtKB/TrEMBL
    B2RUF4
    Conserved Domains (3) summary
    cd11304
    Location:157258
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:73151
    CA; Cadherin repeats
    pfam01049
    Location:631779
    Cadherin_C; Cadherin cytoplasmic region
  15. XM_006529611.4XP_006529674.1  cadherin-7 isoform X1

    See identical proteins and their annotated locations for XP_006529674.1

    UniProtKB/Swiss-Prot
    Q3UVE2, Q67G09, Q8BM92
    UniProtKB/TrEMBL
    B2RUF4
    Related
    ENSMUSP00000108321.2, ENSMUST00000112701.8
    Conserved Domains (3) summary
    cd11304
    Location:157258
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:73151
    CA; Cadherin repeats
    pfam01049
    Location:631779
    Cadherin_C; Cadherin cytoplasmic region
  16. XM_011248008.4XP_011246310.1  cadherin-7 isoform X4

    Conserved Domains (2) summary
    cd11304
    Location:295
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam01049
    Location:248396
    Cadherin_C; Cadherin cytoplasmic region
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