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    Gli2 GLI-Kruppel family member GLI2 [ Mus musculus (house mouse) ]

    Gene ID: 14633, updated on 24-Dec-2024

    Summary

    Official Symbol
    Gli2provided by MGI
    Official Full Name
    GLI-Kruppel family member GLI2provided by MGI
    Primary source
    MGI:MGI:95728
    See related
    Ensembl:ENSMUSG00000048402 AllianceGenome:MGI:95728
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and promoter-specific chromatin binding activity. Involved in gene expression and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryonic morphogenesis; nervous system development; and tube morphogenesis. Located in several cellular components, including axoneme; ciliary tip; and nuclear speck. Is expressed in several structures, including central nervous system; embryo mesenchyme; eye; genitourinary system; and jaw. Human ortholog(s) of this gene implicated in Culler-Jones syndrome; holoprosencephaly 9; and spina bifida. Orthologous to human GLI2 (GLI family zinc finger 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in limb E14.5 (RPKM 11.4), ovary adult (RPKM 6.7) and 14 other tissues See more
    Orthologs
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    Genomic context

    See Gli2 in Genome Data Viewer
    Location:
    1 E2.3; 1 52.17 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (118761791..118987578, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (118834061..119054405, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2900060B14 gene Neighboring gene CLIP associating protein 1 Neighboring gene STARR-positive B cell enhancer mm9_chr1:120355892-120356193 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:120356261-120356370 Neighboring gene STARR-seq mESC enhancer starr_01983 Neighboring gene STARR-seq mESC enhancer starr_01987 Neighboring gene STARR-seq mESC enhancer starr_01991 Neighboring gene transcription factor CP2-like 1 Neighboring gene STARR-seq mESC enhancer starr_01996 Neighboring gene predicted gene, 23497 Neighboring gene STARR-seq mESC enhancer starr_01999 Neighboring gene predicted gene, 51642 Neighboring gene microRNA 6346 Neighboring gene STARR-seq mESC enhancer starr_02009 Neighboring gene STARR-seq mESC enhancer starr_02012 Neighboring gene STARR-seq mESC enhancer starr_02016 Neighboring gene STARR-seq mESC enhancer starr_02017 Neighboring gene STARR-seq mESC enhancer starr_02018 Neighboring gene predicted gene, 41934 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (21)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
    enables chromatin DNA binding PubMed 
    enables chromatin binding PubMed 
    enables metal ion binding  
    enables promoter-specific chromatin binding PubMed 
    enables promoter-specific chromatin binding  
    enables promoter-specific chromatin binding  
    enables protein binding PubMed 
    enables sequence-specific DNA binding PubMed 
    enables sequence-specific DNA binding  
    enables sequence-specific double-stranded DNA binding  
    enables transcription cis-regulatory region binding PubMed 
    enables zinc ion binding  
    Items 1 - 25 of 98
    Process Evidence Code Pubs
    acts_upstream_of_or_within anatomical structure development PubMed 
    acts_upstream_of_or_within anatomical structure development PubMed 
    acts_upstream_of_or_within anatomical structure formation involved in morphogenesis PubMed 
    acts_upstream_of_or_within anterior/posterior pattern specification PubMed 
    acts_upstream_of_or_within axon guidance PubMed 
    acts_upstream_of_or_within branching morphogenesis of an epithelial tube PubMed 
    acts_upstream_of_or_within cell differentiation PubMed 
    acts_upstream_of cell population proliferation PubMed 
    acts_upstream_of cell population proliferation PubMed 
    acts_upstream_of_or_within cellular response to organic cyclic compound PubMed 
    involved_in cellular response to virus  
    acts_upstream_of_or_within cerebellar cortex morphogenesis PubMed 
    acts_upstream_of_or_within cerebellar cortex morphogenesis PubMed 
    acts_upstream_of_or_within chondrocyte differentiation PubMed 
    acts_upstream_of_or_within cochlea morphogenesis PubMed 
    acts_upstream_of_or_within developmental growth PubMed 
    acts_upstream_of_or_within dorsal/ventral neural tube patterning PubMed 
    acts_upstream_of_or_within dorsal/ventral neural tube patterning PubMed 
    acts_upstream_of_or_within dorsal/ventral pattern formation PubMed 
    acts_upstream_of_or_within embryonic digestive tract development PubMed 
    acts_upstream_of_or_within embryonic digit morphogenesis PubMed 
    involved_in epidermal cell differentiation  
    acts_upstream_of epithelial cell proliferation PubMed 
    acts_upstream_of epithelial cell proliferation PubMed 
    acts_upstream_of_or_within floor plate formation PubMed 
    acts_upstream_of_or_within gene expression PubMed 
    involved_in gene expression PubMed 
    involved_in hair follicle morphogenesis  
    acts_upstream_of_or_within head development PubMed 
    acts_upstream_of_or_within heart development PubMed 
    acts_upstream_of_or_within hindbrain development PubMed 
    acts_upstream_of_or_within hindbrain development PubMed 
    acts_upstream_of_or_within hindgut morphogenesis PubMed 
    acts_upstream_of_or_within hindgut morphogenesis PubMed 
    acts_upstream_of_or_within in utero embryonic development PubMed 
    acts_upstream_of_or_within kidney development PubMed 
    acts_upstream_of_or_within lung development PubMed 
    acts_upstream_of_or_within lung development PubMed 
    acts_upstream_of_or_within mammary gland development PubMed 
    acts_upstream_of_or_within mammary gland duct morphogenesis PubMed 
    acts_upstream_of_or_within morphogenesis of an epithelium PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process PubMed 
    acts_upstream_of_or_within negative regulation of chondrocyte differentiation PubMed 
    acts_upstream_of_or_within negative regulation of smoothened signaling pathway PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within neural tube development PubMed 
    acts_upstream_of_or_within neuron development PubMed 
    acts_upstream_of neuron differentiation PubMed 
    acts_upstream_of_or_within notochord regression PubMed 
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth PubMed 
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth PubMed 
    acts_upstream_of_or_within osteoblast development PubMed 
    acts_upstream_of_or_within osteoblast development PubMed 
    acts_upstream_of_or_within osteoblast differentiation PubMed 
    involved_in osteoblast differentiation  
    acts_upstream_of_or_within pattern specification process PubMed 
    acts_upstream_of_or_within pattern specification process PubMed 
    acts_upstream_of_or_within pituitary gland development PubMed 
    involved_in positive regulation of DNA replication  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of DNA-templated transcription  
    acts_upstream_of_or_within positive regulation of cell population proliferation PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of collagen biosynthetic process  
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation PubMed 
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation PubMed 
    acts_upstream_of_or_within positive regulation of neuron differentiation PubMed 
    acts_upstream_of_or_within positive regulation of stem cell proliferation PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within prostatic bud formation PubMed 
    acts_upstream_of_or_within proximal/distal pattern formation PubMed 
    involved_in regulation of DNA-templated transcription  
    acts_upstream_of_or_within regulation of smoothened signaling pathway PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within skeletal system development PubMed 
    involved_in smoothened signaling pathway  
    acts_upstream_of_or_within smoothened signaling pathway PubMed 
    acts_upstream_of_or_within smoothened signaling pathway PubMed 
    involved_in smoothened signaling pathway  
    acts_upstream_of_or_within smoothened signaling pathway involved in dorsal/ventral neural tube patterning PubMed 
    acts_upstream_of_or_within smoothened signaling pathway involved in spinal cord motor neuron cell fate specification PubMed 
    acts_upstream_of_or_within smoothened signaling pathway involved in ventral spinal cord interneuron specification PubMed 
    acts_upstream_of_or_within spinal cord dorsal/ventral patterning PubMed 
    acts_upstream_of_or_within spinal cord dorsal/ventral patterning PubMed 
    acts_upstream_of_or_within spinal cord motor neuron differentiation PubMed 
    acts_upstream_of_or_within spinal cord ventral commissure morphogenesis PubMed 
    acts_upstream_of stem cell proliferation PubMed 
    acts_upstream_of_or_within tube development PubMed 
    acts_upstream_of_or_within ventral midline development PubMed 
    acts_upstream_of_or_within ventral midline development PubMed 
    acts_upstream_of_or_within ventral spinal cord development PubMed 
    Items 1 - 25 of 98
    Component Evidence Code Pubs
    part_of GLI-SUFU complex  
    located_in axoneme PubMed 
    located_in ciliary tip PubMed 
    located_in cilium PubMed 
    located_in cytoplasm PubMed 
    located_in cytoplasm PubMed 
    located_in cytosol  
    located_in membrane PubMed 
    located_in motile cilium PubMed 
    located_in nuclear speck PubMed 
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    zinc finger protein GLI2
    Names
    Tax helper protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081125.1NP_001074594.1  zinc finger protein GLI2

      See identical proteins and their annotated locations for NP_001074594.1

      Status: VALIDATED

      Source sequence(s)
      AK051858, AM262744, BC085190, CJ102399
      Consensus CDS
      CCDS35692.1
      UniProtKB/Swiss-Prot
      E9PYJ4, Q0VGT2
      UniProtKB/TrEMBL
      Q0VGV1
      Related
      ENSMUSP00000054837.9, ENSMUST00000062483.15
      Conserved Domains (4) summary
      COG5048
      Location:488658
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:479569
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:485507
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam09606
      Location:11521467
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      118761791..118987578 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160522.1XP_036016415.1  zinc finger protein GLI2 isoform X4

      UniProtKB/TrEMBL
      Q0VGV1
      Conserved Domains (3) summary
      COG5048
      Location:525695
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:516606
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:522544
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. XM_030248278.2XP_030104138.1  zinc finger protein GLI2 isoform X1

      UniProtKB/Swiss-Prot
      E9PYJ4, Q0VGT2
      UniProtKB/TrEMBL
      Q0VGV1
      Conserved Domains (4) summary
      COG5048
      Location:488658
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:479569
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:485507
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam09606
      Location:11521467
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    3. XM_036160484.1XP_036016377.1  zinc finger protein GLI2 isoform X3

      UniProtKB/TrEMBL
      Q0VGV1
      Conserved Domains (3) summary
      COG5048
      Location:367537
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:358448
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:364386
      ZF_C2H2; C2H2 Zn finger [structural motif]
    4. XM_036160464.1XP_036016357.1  zinc finger protein GLI2 isoform X3

      UniProtKB/TrEMBL
      Q0VGV1
      Conserved Domains (3) summary
      COG5048
      Location:367537
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:358448
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:364386
      ZF_C2H2; C2H2 Zn finger [structural motif]
    5. XM_006529141.4XP_006529204.1  zinc finger protein GLI2 isoform X2

      See identical proteins and their annotated locations for XP_006529204.1

      UniProtKB/TrEMBL
      Q0VGV1
      Conserved Domains (3) summary
      COG5048
      Location:427597
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:418508
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:424446
      ZF_C2H2; C2H2 Zn finger [structural motif]
    6. XM_036160446.1XP_036016339.1  zinc finger protein GLI2 isoform X2

      UniProtKB/TrEMBL
      Q0VGV1
      Conserved Domains (3) summary
      COG5048
      Location:427597
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:418508
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:424446
      ZF_C2H2; C2H2 Zn finger [structural motif]
    7. XM_011247924.4XP_011246226.1  zinc finger protein GLI2 isoform X2

      See identical proteins and their annotated locations for XP_011246226.1

      UniProtKB/TrEMBL
      Q0VGV1
      Conserved Domains (3) summary
      COG5048
      Location:427597
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:418508
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:424446
      ZF_C2H2; C2H2 Zn finger [structural motif]
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