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    OR6B2 olfactory receptor family 6 subfamily B member 2 [ Homo sapiens (human) ]

    Gene ID: 389090, updated on 10-Dec-2024

    Summary

    Official Symbol
    OR6B2provided by HGNC
    Official Full Name
    olfactory receptor family 6 subfamily B member 2provided by HGNC
    Primary source
    HGNC:HGNC:15041
    See related
    Ensembl:ENSG00000182083 AllianceGenome:HGNC:15041
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OR2-1; OR6B2P
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
    Orthologs
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    Genomic context

    See OR6B2 in Genome Data Viewer
    Location:
    2q37.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (240029491..240030429, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (240522204..240523142, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (240968908..240969846, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC150935 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240739699-240740285 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240741003-240741503 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240753063-240753578 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:240835310-240835810 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:240835811-240836311 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240842953-240843860 Neighboring gene NADH:ubiquinone oxidoreductase subunit A10 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:240868321-240868542 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240884202-240885138 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240885139-240886074 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240890573-240891072 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240894992-240895912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240895913-240896833 Neighboring gene microRNA 4786 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17393 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:240964754-240965583 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:240985203-240986402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240994250-240994892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240994893-240995533 Neighboring gene olfactory receptor family 6 subfamily B member 3 Neighboring gene olfactory receptor family 9 subfamily S member 24 pseudogene

    Genomic regions, transcripts, and products

    Phenotypes

    EBI GWAS Catalog

    Description
    Identification of regions associated with variation in sensitivity to food-related odors in the human genome.
    EBI GWAS Catalog

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity  
    enables odorant binding  
    enables olfactory receptor activity  
    Component Evidence Code Pubs
    located_in cytosol  
    located_in plasma membrane  

    General protein information

    Preferred Names
    olfactory receptor 6B2
    Names
    olfactory receptor OR2-1
    olfactory receptor, family 6, subfamily B, member 2 pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005853.1NP_001005853.1  olfactory receptor 6B2

      See identical proteins and their annotated locations for NP_001005853.1

      Status: VALIDATED

      Source sequence(s)
      AB065663
      Consensus CDS
      CCDS46559.1
      UniProtKB/Swiss-Prot
      B2RPR3, Q6IFH4, Q8NGW0
      UniProtKB/TrEMBL
      A0A126GW48
      Related
      ENSP00000322435.5, ENST00000319423.5
      Conserved Domains (1) summary
      cd15224
      Location:40294
      7tmA_OR6B-like; olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      240029491..240030429 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      240522204..240523142 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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