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    Hydr2 alpha/beta hydrolase2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33532, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hydr2provided by FlyBase
    Official Full Name
    alpha/beta hydrolase2provided by FlyBase
    Primary source
    FLYBASE:FBgn0014906
    Locus tag
    Dmel_CG3488
    See related
    AllianceGenome:FB:FBgn0014906
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-23D; anon-23Da; c24; C24; cg3488; CG3488; CT11757; Dmel\CG3488; DMU29170; HYDR2
    Summary
    Enables lipase activity. Involved in lipid metabolic process. Predicted to be active in sperm flagellum and sperm plasma membrane. Is expressed in adult head and organism. Orthologous to human ABHD2 (abhydrolase domain containing 2, acylglycerol lipase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Hydr2 in Genome Data Viewer
    Location:
    23D4-23D4; 2-8 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3163645..3169462)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3163645..3169462)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene glaikit Neighboring gene pseudo Neighboring gene transfer RNA:Serine-AGA 2-3 Neighboring gene uncharacterized protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acetylesterase activity  
    enables lipase activity PubMed 
    enables monoacylglycerol lipase activity  
    Process Evidence Code Pubs
    involved_in acylglycerol catabolic process  
    involved_in lipid metabolic process PubMed 
    involved_in medium-chain fatty acid biosynthetic process  
    involved_in medium-chain fatty acid catabolic process  
    involved_in sperm capacitation  
    involved_in steroid hormone receptor signaling pathway  
    Component Evidence Code Pubs
    is_active_in sperm flagellum  
    is_active_in sperm plasma membrane  

    General protein information

    Preferred Names
    alpha/beta hydrolase2
    Names
    CG3488-PA
    CG3488-PB
    CG3488-PC
    Hydr2-PA
    Hydr2-PB
    Hydr2-PC
    NP_001245852.1
    NP_001259993.1
    NP_608751.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3163645..3169462
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258923.2NP_001245852.1  alpha/beta hydrolase2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245852.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24093, Q9VQM6
      UniProtKB/TrEMBL
      M9NDD5
      Conserved Domains (2) summary
      pfam00561
      Location:115365
      Abhydrolase_1; alpha/beta hydrolase fold
      cl21494
      Location:51381
      Abhydrolase; alpha/beta hydrolases
    2. NM_001273064.1NP_001259993.1  alpha/beta hydrolase2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259993.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5AEM9
      Conserved Domains (2) summary
      pfam00561
      Location:28278
      Abhydrolase_1; alpha/beta hydrolase fold
      cl21494
      Location:5294
      Abhydrolase; alpha/beta hydrolases
    3. NM_134907.4NP_608751.2  alpha/beta hydrolase2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608751.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24093, Q9VQM6
      UniProtKB/TrEMBL
      M9NDD5
      Related
      FBpp0077265
      Conserved Domains (2) summary
      pfam00561
      Location:115365
      Abhydrolase_1; alpha/beta hydrolase fold
      cl21494
      Location:51381
      Abhydrolase; alpha/beta hydrolases
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