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    Galnt2 polypeptide N-acetylgalactosaminyltransferase 2 [ Mus musculus (house mouse) ]

    Gene ID: 108148, updated on 9-Dec-2024

    Summary

    Official Symbol
    Galnt2provided by MGI
    Official Full Name
    polypeptide N-acetylgalactosaminyltransferase 2provided by MGI
    Primary source
    MGI:MGI:894694
    See related
    Ensembl:ENSMUSG00000089704 AllianceGenome:MGI:894694
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable manganese ion binding activity and polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation via serine; protein O-linked glycosylation via threonine; and protein maturation. Predicted to be located in Golgi stack and perinuclear region of cytoplasm. Predicted to be active in Golgi apparatus. Is expressed in several structures, including alimentary system; floor plate; lens; lung mesenchyme; and submandibular gland primordium. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human GALNT2 (polypeptide N-acetylgalactosaminyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 50.6), genital fat pad adult (RPKM 48.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Galnt2 in Genome Data Viewer
    Location:
    8 E2; 8 72.52 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (124958133..125072461)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (124231394..124345722)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22996 Neighboring gene predicted gene 3889 Neighboring gene predicted gene, 42054 Neighboring gene STARR-seq mESC enhancer starr_22999 Neighboring gene STARR-seq mESC enhancer starr_23006 Neighboring gene predicted gene, 24459 Neighboring gene piggyBac transposable element derived 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (2) 
    • Targeted (4)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding  
    enables manganese ion binding  
    enables manganese ion binding  
    enables polypeptide N-acetylgalactosaminyltransferase activity  
    enables polypeptide N-acetylgalactosaminyltransferase activity PubMed 
    enables polypeptide N-acetylgalactosaminyltransferase activity  
    enables polypeptide N-acetylgalactosaminyltransferase activity  
    Process Evidence Code Pubs
    involved_in O-glycan processing  
    involved_in protein O-linked glycosylation  
    acts_upstream_of_or_within protein O-linked glycosylation PubMed 
    involved_in protein O-linked glycosylation  
    involved_in protein O-linked glycosylation  
    involved_in protein O-linked glycosylation via serine  
    involved_in protein O-linked glycosylation via serine  
    involved_in protein O-linked glycosylation via threonine  
    involved_in protein O-linked glycosylation via threonine  
    involved_in protein maturation  
    involved_in protein maturation  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus  
    colocalizes_with Golgi apparatus  
    located_in Golgi apparatus  
    located_in Golgi cisterna membrane  
    located_in Golgi lumen PubMed 
    located_in Golgi stack  
    located_in extracellular region  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  

    General protein information

    Preferred Names
    polypeptide N-acetylgalactosaminyltransferase 2
    Names
    UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2
    galNAc-T2
    polypeptide GalNAc transferase 2
    pp-GaNTase 2
    ppGaNTase-T2
    protein-UDP acetylgalactosaminyltransferase 2
    NP_644678.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139272.2NP_644678.2  polypeptide N-acetylgalactosaminyltransferase 2

      See identical proteins and their annotated locations for NP_644678.2

      Status: VALIDATED

      Source sequence(s)
      BC053063, BC059818, BQ770019
      Consensus CDS
      CCDS22769.1
      UniProtKB/Swiss-Prot
      Q6PB93, Q7TSI5, Q8BL27, Q922K5, Q99ME1
      UniProtKB/TrEMBL
      Q3UA32
      Related
      ENSMUSP00000034458.9, ENSMUST00000034458.9
      Conserved Domains (3) summary
      cd02510
      Location:138433
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      cd00161
      Location:455564
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:445562
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      124958133..125072461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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