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    Stk39 serine/threonine kinase 39 [ Mus musculus (house mouse) ]

    Gene ID: 53416, updated on 10-Dec-2024

    Summary

    Official Symbol
    Stk39provided by MGI
    Official Full Name
    serine/threonine kinase 39provided by MGI
    Primary source
    MGI:MGI:1858416
    See related
    Ensembl:ENSMUSG00000027030 AllianceGenome:MGI:1858416
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DCHT; Rnl5; SPAK; RF005; Gm50618
    Summary
    Enables protein serine/threonine kinase activity. Involved in several processes, including intracellular chloride ion homeostasis; negative regulation of transport; and protein phosphorylation. Acts upstream of or within monoatomic ion homeostasis; regulation of blood pressure; and regulation of inflammatory response. Located in basolateral plasma membrane. Is active in apical plasma membrane and cell body. Is expressed in brain and metanephros. Used to study Gitelman syndrome and pseudohypoaldosteronism. Orthologous to human STK39 (serine/threonine kinase 39). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 29.2), cerebellum adult (RPKM 12.7) and 19 other tissues See more
    Orthologs
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    Genomic context

    See Stk39 in Genome Data Viewer
    Location:
    2; 2 C1.3
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (68040789..68302381, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (68210445..68472108, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 Neighboring gene predicted gene, 54157 Neighboring gene STARR-seq mESC enhancer starr_04706 Neighboring gene actin-like 6A pseudogene Neighboring gene STARR-seq mESC enhancer starr_04707 Neighboring gene STARR-seq mESC enhancer starr_04708 Neighboring gene STARR-seq mESC enhancer starr_04709 Neighboring gene STARR-seq mESC enhancer starr_04712 Neighboring gene predicted gene, 54158 Neighboring gene predicted gene 13596 Neighboring gene Tax1 (human T-cell leukemia virus type I) binding protein 3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (2) 
    • Targeted (10)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 32
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables kinase activity PubMed 
    enables kinase activity  
    enables protein binding PubMed 
    enables protein kinase binding  
    enables protein kinase binding  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 32
    Items 1 - 25 of 51
    Process Evidence Code Pubs
    involved_in cell volume homeostasis  
    involved_in cell volume homeostasis  
    involved_in cellular hyperosmotic response  
    involved_in cellular hyperosmotic response  
    involved_in cellular hyperosmotic response  
    involved_in cellular hypotonic response PubMed 
    involved_in cellular hypotonic response  
    involved_in cellular response to chemokine  
    involved_in cellular response to potassium ion PubMed 
    involved_in chemokine (C-X-C motif) ligand 12 signaling pathway  
    involved_in chemokine (C-X-C motif) ligand 12 signaling pathway  
    involved_in chromatin remodeling  
    involved_in inflammatory response PubMed 
    involved_in intracellular chloride ion homeostasis PubMed 
    involved_in intracellular signal transduction  
    involved_in intracellular signal transduction PubMed 
    involved_in intracellular signal transduction  
    involved_in macrophage activation PubMed 
    involved_in maintenance of lens transparency PubMed 
    acts_upstream_of_or_within monoatomic ion homeostasis PubMed 
    involved_in negative regulation of creatine transmembrane transporter activity  
    involved_in negative regulation of pancreatic juice secretion PubMed 
    involved_in negative regulation of potassium ion transmembrane transport PubMed 
    involved_in negative regulation of potassium ion transmembrane transport  
    involved_in negative regulation of potassium ion transmembrane transporter activity PubMed 
    involved_in negative regulation of potassium ion transmembrane transporter activity  
    involved_in negative regulation of sodium ion transmembrane transporter activity  
    involved_in peptidyl-serine phosphorylation  
    involved_in peptidyl-threonine phosphorylation PubMed 
    involved_in peptidyl-threonine phosphorylation PubMed 
    involved_in peptidyl-threonine phosphorylation  
    involved_in peptidyl-threonine phosphorylation PubMed 
    involved_in positive regulation of T cell chemotaxis  
    involved_in positive regulation of T cell chemotaxis  
    involved_in positive regulation of T cell chemotaxis  
    involved_in positive regulation of p38MAPK cascade  
    involved_in positive regulation of p38MAPK cascade PubMed 
    involved_in positive regulation of potassium ion transport  
    involved_in positive regulation of potassium ion transport  
    involved_in protein autophosphorylation PubMed 
    involved_in protein autophosphorylation  
    involved_in protein autophosphorylation PubMed 
    involved_in protein phosphorylation PubMed 
    acts_upstream_of_or_within regulation of blood pressure PubMed 
    acts_upstream_of_or_within regulation of inflammatory response PubMed 
    involved_in renal sodium ion absorption  
    involved_in renal sodium ion absorption  
    involved_in response to aldosterone PubMed 
    involved_in response to dietary excess PubMed 
    involved_in signal transduction  
    involved_in sodium ion transmembrane transport PubMed 
    Items 1 - 25 of 51
    Component Evidence Code Pubs
    is_active_in apical plasma membrane PubMed 
    located_in apical plasma membrane PubMed 
    located_in basolateral plasma membrane PubMed 
    is_active_in cell body PubMed 
    located_in cell cortex  
    located_in cell cortex  
    is_active_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol  
    located_in cytosol PubMed 
    located_in intracellular membrane-bounded organelle  
    located_in membrane PubMed 
    located_in nucleoplasm  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    STE20/SPS1-related proline-alanine-rich protein kinase
    Names
    Ste-20 related kinase
    kidney-specific SPAK
    serine/threonine kinase 39, STE20/SPS1 homolog
    serine/threonine-protein kinase 39
    ste-20-related kinase
    NP_001399473.1
    NP_001399474.1
    NP_001399475.1
    NP_001399476.1
    NP_001408409.1
    NP_001408410.1
    NP_058562.1
    XP_017174617.1
    XP_017174618.1
    XP_017174619.1
    XP_030107738.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412544.1NP_001399473.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL844841, AL845486
    2. NM_001412545.1NP_001399474.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL844841, AL845486, BX936296
    3. NM_001412546.1NP_001399475.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL844841, AL845486, BX936296
    4. NM_001412547.1NP_001399476.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL844841, AL845486, BX936296
    5. NM_001421480.1NP_001408409.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL844841, AL845486
      Related
      ENSMUST00000123781.8
    6. NM_001421481.1NP_001408410.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL845486, BX936296
    7. NM_016866.3NP_058562.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform 1

      See identical proteins and their annotated locations for NP_058562.1

      Status: VALIDATED

      Source sequence(s)
      AL844841, AL845486, BX936296
      Consensus CDS
      CCDS16084.1
      UniProtKB/Swiss-Prot
      Q80W13, Q9Z1W9
      UniProtKB/TrEMBL
      A2AQL0
      Related
      ENSMUSP00000099776.4, ENSMUST00000102715.4
      Conserved Domains (2) summary
      smart00220
      Location:75349
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06610
      Location:73349
      STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

    RNA

    1. NR_178213.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL844841, AL845486, BX936296

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      68040789..68302381 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319130.2XP_017174619.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform X4

      Conserved Domains (2) summary
      cd06610
      Location:11277
      STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase
      pfam12202
      Location:391448
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    2. XM_017319129.1XP_017174618.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform X2

      Conserved Domains (2) summary
      cd06610
      Location:5271
      STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase
      pfam12202
      Location:364421
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    3. XM_017319128.1XP_017174617.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform X1

      Conserved Domains (2) summary
      cd06610
      Location:5271
      STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase
      pfam12202
      Location:385442
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    4. XM_030251878.2XP_030107738.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform X5

      UniProtKB/TrEMBL
      G1JLS7, Q3V256
      Conserved Domains (2) summary
      pfam12202
      Location:213270
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
      cl21453
      Location:199
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_003953672.1 RNA Sequence

    2. XR_001783147.1 RNA Sequence

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