U.S. flag

An official website of the United States government

Prox1 prospero homeobox 1 [ Mus musculus (house mouse) ]

Gene ID: 19130, updated on 24-Dec-2024

Summary

Official Symbol
Prox1provided by MGI
Official Full Name
prospero homeobox 1provided by MGI
Primary source
MGI:MGI:97772
See related
Ensembl:ENSMUSG00000010175 AllianceGenome:MGI:97772
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PROX-1; A230003G05Rik
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including camera-type eye morphogenesis; circulatory system development; and positive regulation of cell differentiation. Acts upstream of or within several processes, including epithelial cell differentiation; hepatocyte cell migration; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; sensory organ; and skin. Used to study dilated cardiomyopathy and obesity. Orthologous to human PROX1 (prospero homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in liver adult (RPKM 6.6), heart adult (RPKM 5.0) and 19 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Prox1 in Genome Data Viewer
Location:
1 H6; 1 95.85 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (189850232..189903024, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (190118035..190170827, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03414 Neighboring gene predicted gene, 39736 Neighboring gene predicted gene, 30446 Neighboring gene prospero homeobox 1, opposite strand Neighboring gene predicted gene, 39737 Neighboring gene predicted gene, 29678

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (11)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding  
enables DNA binding domain binding  
enables DNA binding domain binding  
enables DNA-binding transcription factor activity PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific  
enables DNA-binding transcription factor activity, RNA polymerase II-specific PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
enables LBD domain binding  
enables LBD domain binding  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
enables nuclear receptor binding  
enables nuclear receptor binding  
enables protein binding PubMed 
enables sequence-specific DNA binding PubMed 
enables sequence-specific double-stranded DNA binding  
enables transcription cis-regulatory region binding  
Items 1 - 25 of 69
Process Evidence Code Pubs
acts_upstream_of_or_within acinar cell differentiation PubMed 
involved_in aorta smooth muscle tissue morphogenesis PubMed 
involved_in atrial cardiac muscle tissue morphogenesis PubMed 
acts_upstream_of_or_within blood vessel endothelial cell differentiation PubMed 
acts_upstream_of_or_within branching involved in pancreas morphogenesis PubMed 
acts_upstream_of cell population proliferation PubMed 
involved_in cerebellar granule cell differentiation PubMed 
involved_in circadian rhythm PubMed 
involved_in dentate gyrus development PubMed 
involved_in embryonic retina morphogenesis in camera-type eye PubMed 
involved_in endocardium formation PubMed 
acts_upstream_of_or_within epithelial cell migration PubMed 
acts_upstream_of_or_within hepatocyte cell migration PubMed 
involved_in hepatocyte differentiation PubMed 
acts_upstream_of_or_within hepatocyte proliferation PubMed 
acts_upstream_of_or_within inner ear development PubMed 
involved_in kidney development  
involved_in lens fiber cell morphogenesis PubMed 
involved_in lens morphogenesis in camera-type eye PubMed 
involved_in lens placode formation involved in camera-type eye formation PubMed 
involved_in lung development  
acts_upstream_of_or_within lymph vessel development PubMed 
involved_in lymphangiogenesis  
involved_in lymphangiogenesis  
acts_upstream_of_or_within lymphatic endothelial cell differentiation PubMed 
involved_in lymphatic endothelial cell differentiation  
involved_in lymphatic endothelial cell fate commitment  
involved_in lymphatic endothelial cell fate commitment  
involved_in negative regulation of DNA-binding transcription factor activity  
involved_in negative regulation of DNA-templated transcription PubMed 
involved_in negative regulation of DNA-templated transcription  
involved_in negative regulation of bile acid biosynthetic process  
involved_in negative regulation of bile acid biosynthetic process  
involved_in negative regulation of cell population proliferation  
acts_upstream_of_or_within negative regulation of neuroblast proliferation PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
involved_in negative regulation of transcription by RNA polymerase II  
involved_in negative regulation of viral genome replication  
involved_in negative regulation of viral genome replication  
acts_upstream_of neuroblast proliferation PubMed 
acts_upstream_of_or_within neuron fate determination PubMed 
involved_in neuronal stem cell population maintenance PubMed 
involved_in positive regulation of cell cycle PubMed 
acts_upstream_of_or_within positive regulation of cell cycle checkpoint PubMed 
involved_in positive regulation of cell population proliferation PubMed 
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity  
involved_in positive regulation of endothelial cell migration  
involved_in positive regulation of endothelial cell migration  
involved_in positive regulation of endothelial cell proliferation  
involved_in positive regulation of endothelial cell proliferation  
involved_in positive regulation of forebrain neuron differentiation PubMed 
involved_in positive regulation of heart growth PubMed 
involved_in positive regulation of neural precursor cell proliferation PubMed 
involved_in positive regulation of sarcomere organization PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
involved_in positive regulation of transcription by RNA polymerase II  
involved_in regulation of circadian rhythm  
involved_in regulation of circadian rhythm  
involved_in regulation of gene expression PubMed 
involved_in regulation of gene expression  
involved_in regulation of transcription by RNA polymerase II  
involved_in response to nutrient levels  
involved_in skeletal muscle thin filament assembly PubMed 
acts_upstream_of transcription by RNA polymerase II PubMed 
involved_in venous blood vessel morphogenesis PubMed 
involved_in ventricular cardiac muscle tissue morphogenesis PubMed 
involved_in ventricular cardiac myofibril assembly PubMed 
involved_in ventricular septum morphogenesis PubMed 
Items 1 - 25 of 69
Component Evidence Code Pubs
located_in cytoplasm PubMed 
located_in cytoplasm  
located_in cytosol  
located_in cytosol  
located_in nucleoplasm  
located_in nucleoplasm  
is_active_in nucleus  
located_in nucleus PubMed 
located_in nucleus  
located_in nucleus  

General protein information

Preferred Names
prospero homeobox protein 1
Names
homeobox prospero-like protein PROX1
prospero-related homeobox 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360827.2NP_001347756.1  prospero homeobox protein 1

    Status: VALIDATED

    Source sequence(s)
    AC026911, AC126032
    Consensus CDS
    CCDS35822.1
    UniProtKB/Swiss-Prot
    O88478, P48437, Q3UPV1, Q543D8
    Related
    ENSMUSP00000010319.8, ENSMUST00000010319.14
    Conserved Domains (1) summary
    pfam05044
    Location:579730
    HPD; Homeo-prospero domain
  2. NM_008937.4NP_032963.1  prospero homeobox protein 1

    See identical proteins and their annotated locations for NP_032963.1

    Status: VALIDATED

    Source sequence(s)
    AC026911, AC126032
    Consensus CDS
    CCDS35822.1
    UniProtKB/Swiss-Prot
    O88478, P48437, Q3UPV1, Q543D8
    Related
    ENSMUSP00000135703.2, ENSMUST00000175916.8
    Conserved Domains (1) summary
    pfam05044
    Location:579730
    HPD; Homeo-prospero domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    189850232..189903024 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497127.5XP_006497190.1  prospero homeobox protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006497190.1

    Conserved Domains (1) summary
    pfam05044
    Location:579731
    HPD; Homeo-prospero domain
  2. XM_036162790.1XP_036018683.1  prospero homeobox protein 1 isoform X2

    UniProtKB/Swiss-Prot
    O88478, P48437, Q3UPV1, Q543D8
    Conserved Domains (1) summary
    pfam05044
    Location:579730
    HPD; Homeo-prospero domain
  3. XM_006497126.5XP_006497189.1  prospero homeobox protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006497189.1

    Conserved Domains (1) summary
    pfam05044
    Location:579731
    HPD; Homeo-prospero domain
  4. XM_006497125.5XP_006497188.1  prospero homeobox protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006497188.1

    Conserved Domains (1) summary
    pfam05044
    Location:579731
    HPD; Homeo-prospero domain
External link. Please review our privacy policy.