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MCF2L MCF.2 cell line derived transforming sequence like [ Homo sapiens (human) ]

Gene ID: 23263, updated on 10-Dec-2024

Summary

Official Symbol
MCF2Lprovided by HGNC
Official Full Name
MCF.2 cell line derived transforming sequence likeprovided by HGNC
Primary source
HGNC:HGNC:14576
See related
Ensembl:ENSG00000126217 MIM:609499; AllianceGenome:HGNC:14576
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DBS; OST; ARHGEF14
Summary
This gene encodes a guanine nucleotide exchange factor that interacts specifically with the GTP-bound Rac1 and plays a role in the Rho/Rac signaling pathways. A variant in this gene was associated with osteoarthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in fat (RPKM 8.1), brain (RPKM 8.0) and 22 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See MCF2L in Genome Data Viewer
Location:
13q34
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (112894335..113099742)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (112144372..112351082)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (113623528..113754056)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ATPase phospholipid transporting 11A Neighboring gene uncharacterized LOC124903253 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113430716-113431329 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:113432945-113433094 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113434144-113435009 Neighboring gene uncharacterized LOC124903252 Neighboring gene NANOG hESC enhancer GRCh37_chr13:113444396-113445115 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8035 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113460948-113461629 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113462993-113463672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113505150-113505650 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:113526644-113527843 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:113529546-113529735 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 13:113533651 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 13:113534907 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 13:113536132 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 13:113537448 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 13:113539894 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113540393-113540968 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 13:113543499 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113546091-113546840 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113552283-113552788 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113556232-113557108 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113557109-113557983 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113559740-113560614 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113560615-113561488 Neighboring gene uncharacterized LOC124903214 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113583655-113584497 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5536 Neighboring gene Sharpr-MPRA regulatory region 2656 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113607452-113608169 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113610492-113611232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113611233-113611972 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113611973-113612713 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113615435-113616158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113617605-113618326 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113622683-113623202 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5537 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113632813-113633750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113635625-113636560 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113639843-113640840 Neighboring gene MCF2L antisense RNA 1 Neighboring gene uncharacterized LOC107984591 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113668429-113668957 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113676327-113676961 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113676962-113677597 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113681619-113682120 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113682121-113682620 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113684208-113684732 Neighboring gene Sharpr-MPRA regulatory region 5526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113695415-113696161 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113704798-113705384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113744195-113744700 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113746783-113747284 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113747285-113747784 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113750605-113751105 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113783538-113784264 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113784265-113784991 Neighboring gene F10 antisense RNA 1 Neighboring gene coagulation factor VII Neighboring gene coagulation factor X

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A variant in MCF2L is associated with osteoarthritis.
EBI GWAS Catalog
Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study.
EBI GWAS Catalog
Genome-wide association study identifies multiple loci associated with bladder cancer risk.
EBI GWAS Catalog
Ischemic stroke is associated with the ABO locus: the EuroCLOT study.
EBI GWAS Catalog

Pathways from PubChem

Interactions

General gene information

Clone Names

  • FLJ12122, KIAA0362

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in cytosol  
located_in endomembrane system PubMed 
located_in endomembrane system  
located_in extracellular space PubMed 
located_in extrinsic component of cytoplasmic side of plasma membrane PubMed 
located_in plasma membrane  

General protein information

Preferred Names
guanine nucleotide exchange factor DBS
Names
DBL's big sister
MCF2 transforming sequence-like protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112732.3NP_001106203.2  guanine nucleotide exchange factor DBS isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AK295670, AL137002, AL356740, AW241629
    Consensus CDS
    CCDS45070.2
    UniProtKB/TrEMBL
    H7C275
    Related
    ENSP00000440374.2, ENST00000535094.7
    Conserved Domains (6) summary
    cd11857
    Location:10291082
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:46191
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:602779
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:322509
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:786917
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:800914
    PH; PH domain
  2. NM_001320815.2NP_001307744.1  guanine nucleotide exchange factor DBS isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and contains an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (c) has a distinct N-terminus and is longer than isoform a.
    Source sequence(s)
    AK295047, AL137002, AL162454, AW241629, DA348090, DB476653
    UniProtKB/TrEMBL
    H7C275
    Conserved Domains (6) summary
    cd11857
    Location:10521105
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:44189
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:600777
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:320507
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:784915
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:798912
    PH; PH domain
  3. NM_001320816.2NP_001307745.1  guanine nucleotide exchange factor DBS isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (d) with a distinct and shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AB116074, AK295047, AL137002, AW241629, DB276568
    UniProtKB/TrEMBL
    H7C275
    Related
    ENSP00000397285.1, ENST00000421756.5
    Conserved Domains (6) summary
    cd11857
    Location:10331086
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:50195
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:606783
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:326513
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:790921
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:804918
    PH; PH domain
  4. NM_001320817.2NP_001307746.1  guanine nucleotide exchange factor DBS isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains differences in the both UTRs and both the 5' and 3' coding regions, compared to variant 1. The resulting isoform (e) has distinct N- and C-termini and is shorter than isoform a.
    Source sequence(s)
    AK295047, BC020208, DB476653
    Consensus CDS
    CCDS81782.1
    UniProtKB/TrEMBL
    A0A994J4L8
    Related
    ENSP00000364747.4, ENST00000375597.8
    Conserved Domains (4) summary
    smart00516
    Location:44189
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:600777
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:320507
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:784915
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
  5. NM_001366644.2NP_001353573.1  guanine nucleotide exchange factor DBS isoform f

    Status: REVIEWED

    Source sequence(s)
    AL137002, AL162454, AL356740, AL596093
    UniProtKB/TrEMBL
    H7C275
    Conserved Domains (5) summary
    cd11857
    Location:10001053
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:17162
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:573750
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:293480
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:757888
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
  6. NM_001366645.2NP_001353574.1  guanine nucleotide exchange factor DBS isoform g

    Status: REVIEWED

    Source sequence(s)
    AL137002, AL162454, AL596093
    UniProtKB/TrEMBL
    H7C275
  7. NM_001366646.2NP_001353575.1  guanine nucleotide exchange factor DBS isoform h

    Status: REVIEWED

    Source sequence(s)
    AL137002, AL162454, AL596093
    UniProtKB/TrEMBL
    H7C275
  8. NM_024979.4NP_079255.4  guanine nucleotide exchange factor DBS isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (b) with a distinct and shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AK295047, AL137002, AL162454, AW241629, DB476653
    Consensus CDS
    CCDS9527.3
    UniProtKB/TrEMBL
    H7C275
    Related
    ENSP00000364754.3, ENST00000375604.6
    Conserved Domains (6) summary
    cd11857
    Location:10271080
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:44189
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:600777
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:320507
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:784915
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:798912
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    112894335..113099742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537482.2XP_011535784.1  guanine nucleotide exchange factor DBS isoform X2

    See identical proteins and their annotated locations for XP_011535784.1

    UniProtKB/TrEMBL
    H7C275
    Conserved Domains (6) summary
    cd11857
    Location:11151168
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:76221
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:632809
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:352563
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:816947
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:830944
    PH; PH domain
  2. XM_047430220.1XP_047286176.1  guanine nucleotide exchange factor DBS isoform X8

    UniProtKB/TrEMBL
    H7C275
  3. XM_047430221.1XP_047286177.1  guanine nucleotide exchange factor DBS isoform X11

    UniProtKB/Swiss-Prot
    A2A2X1, A2A2X2, A2A3G6, A2A3G8, B4DHD6, B4DIL6, E9PDN8, O15068, Q5JU56, Q5VXT1, Q6ZWD4, Q765G8, Q765G9, Q8N679
    Related
    ENSP00000364758.3, ENST00000375608.7
  4. XM_047430226.1XP_047286182.1  guanine nucleotide exchange factor DBS isoform X18

    UniProtKB/TrEMBL
    A0A994J4L8
  5. XM_011537483.3XP_011535785.1  guanine nucleotide exchange factor DBS isoform X2

    See identical proteins and their annotated locations for XP_011535785.1

    UniProtKB/TrEMBL
    H7C275
    Conserved Domains (6) summary
    cd11857
    Location:11151168
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:76221
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:632809
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:352563
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:816947
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:830944
    PH; PH domain
  6. XM_047430222.1XP_047286178.1  guanine nucleotide exchange factor DBS isoform X11

    UniProtKB/Swiss-Prot
    A2A2X1, A2A2X2, A2A3G6, A2A3G8, B4DHD6, B4DIL6, E9PDN8, O15068, Q5JU56, Q5VXT1, Q6ZWD4, Q765G8, Q765G9, Q8N679
  7. XM_011537486.3XP_011535788.3  guanine nucleotide exchange factor DBS isoform X1

    UniProtKB/TrEMBL
    A0A2X0U4S1
  8. XM_017020493.2XP_016875982.2  guanine nucleotide exchange factor DBS isoform X3

    UniProtKB/TrEMBL
    A0A2X0U4S1
  9. XM_017020495.2XP_016875984.2  guanine nucleotide exchange factor DBS isoform X6

    UniProtKB/TrEMBL
    A0A2X0U4S1
    Related
    ENSP00000380225.1, ENST00000397030.5
  10. XM_017020499.3XP_016875988.2  guanine nucleotide exchange factor DBS isoform X17

    UniProtKB/TrEMBL
    A0A994J4L8
  11. XM_011537485.2XP_011535787.1  guanine nucleotide exchange factor DBS isoform X7

    UniProtKB/TrEMBL
    H0Y4M6, H7C275
    Related
    ENSP00000392953.2, ENST00000453297.6
    Conserved Domains (6) summary
    cd11857
    Location:10851138
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:46191
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:602779
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:322509
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:786917
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:800914
    PH; PH domain
  12. XM_047430223.1XP_047286179.1  guanine nucleotide exchange factor DBS isoform X14

    UniProtKB/TrEMBL
    H7C275
    Related
    ENSP00000404422.2, ENST00000420013.6
  13. XM_011537488.2XP_011535790.1  guanine nucleotide exchange factor DBS isoform X10

    UniProtKB/TrEMBL
    H7C275
    Conserved Domains (6) summary
    cd11857
    Location:10671120
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:28173
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:584761
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:304491
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:768899
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:782896
    PH; PH domain
  14. XM_011537490.2XP_011535792.1  guanine nucleotide exchange factor DBS isoform X12

    UniProtKB/TrEMBL
    H7C275
    Conserved Domains (6) summary
    cd11857
    Location:10561109
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:17162
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:573750
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:293480
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:757888
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:771885
    PH; PH domain
  15. XM_011537484.2XP_011535786.1  guanine nucleotide exchange factor DBS isoform X5

    UniProtKB/TrEMBL
    H7C275
    Conserved Domains (6) summary
    cd11857
    Location:10891142
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:50195
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:606783
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:326513
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:790921
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:804918
    PH; PH domain
  16. XM_017020494.2XP_016875983.1  guanine nucleotide exchange factor DBS isoform X4

    UniProtKB/TrEMBL
    H7C275
  17. XM_047430224.1XP_047286180.1  guanine nucleotide exchange factor DBS isoform X15

    UniProtKB/TrEMBL
    H7C275
  18. XM_011537487.2XP_011535789.1  guanine nucleotide exchange factor DBS isoform X9

    UniProtKB/TrEMBL
    H7C275
    Conserved Domains (6) summary
    cd11857
    Location:10831136
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:44189
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:600777
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:320507
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:784915
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:798912
    PH; PH domain
  19. XM_047430225.1XP_047286181.1  guanine nucleotide exchange factor DBS isoform X16

    UniProtKB/TrEMBL
    H7C275
  20. XM_011537491.2XP_011535793.1  guanine nucleotide exchange factor DBS isoform X13

    UniProtKB/TrEMBL
    H7C275
    Conserved Domains (6) summary
    cd11857
    Location:10471100
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:62153
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:564741
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:284471
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:748879
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:762876
    PH; PH domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    112144372..112351082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374335.1XP_054230310.1  guanine nucleotide exchange factor DBS isoform X11

    UniProtKB/Swiss-Prot
    A2A2X1, A2A2X2, A2A3G6, A2A3G8, B4DHD6, B4DIL6, E9PDN8, O15068, Q5JU56, Q5VXT1, Q6ZWD4, Q765G8, Q765G9, Q8N679
  2. XM_054374324.1XP_054230299.1  guanine nucleotide exchange factor DBS isoform X2

    UniProtKB/TrEMBL
    H7C275
  3. XM_054374331.1XP_054230306.1  guanine nucleotide exchange factor DBS isoform X8

    UniProtKB/TrEMBL
    H7C275
  4. XM_054374342.1XP_054230317.1  guanine nucleotide exchange factor DBS isoform X18

    UniProtKB/TrEMBL
    A0A994J4L8
  5. XM_054374325.1XP_054230300.1  guanine nucleotide exchange factor DBS isoform X2

    UniProtKB/TrEMBL
    H7C275
  6. XM_054374334.1XP_054230309.1  guanine nucleotide exchange factor DBS isoform X11

    UniProtKB/Swiss-Prot
    A2A2X1, A2A2X2, A2A3G6, A2A3G8, B4DHD6, B4DIL6, E9PDN8, O15068, Q5JU56, Q5VXT1, Q6ZWD4, Q765G8, Q765G9, Q8N679
  7. XM_054374323.1XP_054230298.1  guanine nucleotide exchange factor DBS isoform X19

    UniProtKB/TrEMBL
    A0A2X0U4S1
  8. XM_054374326.1XP_054230301.1  guanine nucleotide exchange factor DBS isoform X20

    UniProtKB/TrEMBL
    A0A2X0U4S1
  9. XM_054374329.1XP_054230304.1  guanine nucleotide exchange factor DBS isoform X21

    UniProtKB/TrEMBL
    A0A2X0U4S1
  10. XM_054374341.1XP_054230316.1  guanine nucleotide exchange factor DBS isoform X22

    UniProtKB/TrEMBL
    A0A2X0U4S1
  11. XM_054374330.1XP_054230305.1  guanine nucleotide exchange factor DBS isoform X7

    UniProtKB/TrEMBL
    H0Y4M6, H7C275
  12. XM_054374338.1XP_054230313.1  guanine nucleotide exchange factor DBS isoform X14

    UniProtKB/TrEMBL
    H7C275
  13. XM_054374333.1XP_054230308.1  guanine nucleotide exchange factor DBS isoform X10

    UniProtKB/TrEMBL
    H7C275
  14. XM_054374336.1XP_054230311.1  guanine nucleotide exchange factor DBS isoform X12

    UniProtKB/TrEMBL
    H7C275
  15. XM_054374328.1XP_054230303.1  guanine nucleotide exchange factor DBS isoform X5

    UniProtKB/TrEMBL
    H7C275
  16. XM_054374327.1XP_054230302.1  guanine nucleotide exchange factor DBS isoform X4

    UniProtKB/TrEMBL
    H7C275
  17. XM_054374339.1XP_054230314.1  guanine nucleotide exchange factor DBS isoform X15

    UniProtKB/TrEMBL
    H7C275
  18. XM_054374332.1XP_054230307.1  guanine nucleotide exchange factor DBS isoform X9

    UniProtKB/TrEMBL
    H7C275
  19. XM_054374340.1XP_054230315.1  guanine nucleotide exchange factor DBS isoform X16

    UniProtKB/TrEMBL
    H7C275
  20. XM_054374337.1XP_054230312.1  guanine nucleotide exchange factor DBS isoform X13

    UniProtKB/TrEMBL
    H7C275
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