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DopEcR Dopamine/Ecdysteroid receptor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38539, updated on 9-Dec-2024

Summary

Official Symbol
DopEcRprovided by FlyBase
Official Full Name
Dopamine/Ecdysteroid receptorprovided by FlyBase
Primary source
FLYBASE:FBgn0035538
Locus tag
Dmel_CG18314
See related
AllianceGenome:FB:FBgn0035538
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0170980.139; anon-WO0170980.140; CG18314; DmDopEcR; Dmel\CG18314; dop; DopECR
Summary
Enables dopamine neurotransmitter receptor activity, coupled via Gs and ecdysone binding activity. Involved in several processes, including behavioral response to ethanol; cellular response to sucrose stimulus; and learning. Located in plasma membrane. Is expressed in several structures, including adult antennal lobe; adult brain; adult head; adult mushroom body; and ganglia. Used to study alcohol use disorder and renal fibrosis. Orthologous to human GPR21 (G protein-coupled receptor 21) and GPR52 (G protein-coupled receptor 52). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See DopEcR in Genome Data Viewer
Location:
64B2-64B3; 3-12 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4367649..4380387, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4367649..4380387, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein S6 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44360 Neighboring gene uncharacterized protein Neighboring gene slowdown

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway  
involved_in G protein-coupled receptor signaling pathway PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway PubMed 
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway  
involved_in associative learning PubMed 
involved_in behavioral response to ethanol PubMed 
involved_in cellular response to starvation PubMed 
involved_in cellular response to sucrose stimulus PubMed 
involved_in habituation PubMed 
involved_in positive regulation of MAPK cascade  
involved_in positive regulation of MAPK cascade PubMed 
involved_in response to ecdysone PubMed 
involved_in response to ethanol PubMed 
involved_in response to starvation PubMed 
involved_in response to sucrose PubMed 
Component Evidence Code Pubs
located_in membrane  
located_in membrane PubMed 
is_active_in plasma membrane  
located_in plasma membrane PubMed 

General protein information

Preferred Names
Dopamine/Ecdysteroid receptor
Names
CG18314-PA
CG18314-PB
CG18314-PC
DopEcR-PA
DopEcR-PB
DopEcR-PC
dopamine/ecdysteroid receptor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    4367649..4380387 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001014560.2 → NP_001014560.1  Dopamine/Ecdysteroid receptor, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014560.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MR64, Q8T0P6, Q9VZD1
    Conserved Domains (1) summary
    cd00637
    Location:18 → 289
    7tm_classA_rhodopsin-like; rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily
  2. NM_001014559.3 → NP_001014559.1  Dopamine/Ecdysteroid receptor, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014559.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MR64, Q8T0P6, Q9VZD1
    Conserved Domains (1) summary
    cd00637
    Location:18 → 289
    7tm_classA_rhodopsin-like; rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily
  3. NM_139640.3 → NP_647897.2  Dopamine/Ecdysteroid receptor, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647897.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MR64, Q8T0P6, Q9VZD1
    Related
    FBpp0073193
    Conserved Domains (1) summary
    cd00637
    Location:18 → 289
    7tm_classA_rhodopsin-like; rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily
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