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    Nabp1 nucleic acid binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 109019, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nabp1provided by MGI
    Official Full Name
    nucleic acid binding protein 1provided by MGI
    Primary source
    MGI:MGI:1923258
    See related
    Ensembl:ENSMUSG00000026107 AllianceGenome:MGI:1923258
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nbp1; Ssb2; Obfc2a; 4930434H03Rik; 4930442A21Rik; 4930488J04Rik; 4933440J18Rik; 5830411E10Rik
    Summary
    Enables RNA binding activity and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination; mitotic G2/M transition checkpoint; and response to ionizing radiation. Located in chromosome, telomeric region and nucleus. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human NABP1 (nucleic acid binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 17.6), placenta adult (RPKM 13.4) and 15 other tissues See more
    Orthologs
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    Genomic context

    See Nabp1 in Genome Data Viewer
    Location:
    1 C1.1; 1 26.58 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (51504127..51517634, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (51464968..51478475, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9330175M20 gene Neighboring gene caveolae associated 2 Neighboring gene THO complex 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00877 Neighboring gene STARR-seq mESC enhancer starr_00878 Neighboring gene STARR-positive B cell enhancer mm9_chr1:51515795-51516095 Neighboring gene STARR-positive B cell enhancer ABC_E7721 Neighboring gene STARR-positive B cell enhancer ABC_E1542 Neighboring gene STARR-seq mESC enhancer starr_00879 Neighboring gene STARR-seq mESC enhancer starr_00881 Neighboring gene predicted gene, 17767 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:51641775-51642017 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:51650842-51651025 Neighboring gene STARR-positive B cell enhancer mm9_chr1:51653904-51654205 Neighboring gene STARR-seq mESC enhancer starr_00883 Neighboring gene predicted gene, 31636

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding  
    enables RNA binding PubMed 
    enables single-stranded DNA binding PubMed 
    enables single-stranded DNA binding  
    Process Evidence Code Pubs
    involved_in DNA damage response  
    involved_in DNA damage response  
    involved_in DNA repair  
    involved_in DNA repair  
    involved_in double-strand break repair via homologous recombination  
    involved_in double-strand break repair via homologous recombination  
    involved_in double-strand break repair via homologous recombination  
    involved_in mitotic G2/M transition checkpoint  
    involved_in mitotic G2/M transition checkpoint  
    involved_in mitotic G2/M transition checkpoint  
    involved_in response to ionizing radiation  
    involved_in response to ionizing radiation  
    involved_in response to ionizing radiation  
    Component Evidence Code Pubs
    part_of SOSS complex  
    part_of SOSS complex  
    part_of SOSS complex  
    located_in chromosome, telomeric region PubMed 
    located_in cytosol  
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in nucleus  
    located_in site of double-strand break  
    located_in site of double-strand break  

    General protein information

    Preferred Names
    SOSS complex subunit B2
    Names
    SOSS-B2
    oligonucleotide/oligosaccharide-binding fold containing 2A
    oligonucleotide/oligosaccharide-binding fold-containing protein 2A
    sensor of single-strand DNA complex subunit B2
    sensor of ssDNA subunit B2
    single-stranded DNA-binding protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310548.1NP_001297477.1  SOSS complex subunit B2 isoform b

      See identical proteins and their annotated locations for NP_001297477.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction in the 5' end compared to variant 1, which results in translation from a downstream AUG. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC125518, AK167652, AY880264, BB609822, BY089463
      Consensus CDS
      CCDS78580.1
      UniProtKB/Swiss-Prot
      Q8BGW5
      Related
      ENSMUSP00000140557.2, ENSMUST00000185534.2
      Conserved Domains (1) summary
      PLN02216
      Location:3671
      PLN02216; protein SRG1
    2. NM_001310549.1NP_001297478.1  SOSS complex subunit B2 isoform b

      See identical proteins and their annotated locations for NP_001297478.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction in the 5' end compared to variant 1, which results in translation from a downstream AUG. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AK167652, AY880264, BB609822
      Consensus CDS
      CCDS78580.1
      UniProtKB/Swiss-Prot
      Q8BGW5
      Related
      ENSMUSP00000140469.2, ENSMUST00000188204.7
      Conserved Domains (1) summary
      PLN02216
      Location:3671
      PLN02216; protein SRG1
    3. NM_028696.3NP_082972.2  SOSS complex subunit B2 isoform a

      See identical proteins and their annotated locations for NP_082972.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AY880264
      Consensus CDS
      CCDS35559.1
      UniProtKB/Swiss-Prot
      Q8BGW5, Q8C154, Q8C164
      UniProtKB/TrEMBL
      Q8R2P2
      Related
      ENSMUSP00000027279.6, ENSMUST00000027279.12
      Conserved Domains (1) summary
      cd04491
      Location:2299
      SoSSB_OBF; SoSSB_OBF: A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      51504127..51517634 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003956258.1 RNA Sequence

    2. XR_001785093.3 RNA Sequence

    3. XR_001785084.3 RNA Sequence

    4. XR_001785088.3 RNA Sequence

    5. XR_004934047.1 RNA Sequence

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