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    Slc28a2 solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 [ Mus musculus (house mouse) ]

    Gene ID: 269346, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc28a2provided by MGI
    Official Full Name
    solute carrier family 28 (sodium-coupled nucleoside transporter), member 2provided by MGI
    Primary source
    MGI:MGI:1913105
    See related
    Ensembl:ENSMUSG00000027219 AllianceGenome:MGI:1913105
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cnt2; SPNT; B430217P18; 2010208B10Rik
    Summary
    Enables purine nucleoside transmembrane transporter activity. Predicted to be involved in several processes, including nucleoside transport; protein localization to cell surface; and purine nucleobase transmembrane transport. Located in brush border membrane. Is expressed in foregut-midgut junction; midgut; and placenta. Orthologous to human SLC28A2 (solute carrier family 28 member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in small intestine adult (RPKM 25.8), large intestine adult (RPKM 20.5) and 7 other tissues See more
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    Genomic context

    See Slc28a2 in Genome Data Viewer
    Location:
    2 E5; 2 60.63 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (122256836..122291633)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (122426357..122461152)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39918 Neighboring gene nuclear encoded tRNA histidine 5 (anticodon GTG) Neighboring gene predicted gene, 24409 Neighboring gene STARR-positive B cell enhancer mm9_chr2:122234690-122234991 Neighboring gene STARR-positive B cell enhancer ABC_E7855 Neighboring gene BMP and activin membrane-bound inhibitor, pseudogene (Xenopus laevis) Neighboring gene solute carrier family 28 member 2b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in apicolateral plasma membrane  
    located_in apicolateral plasma membrane  
    located_in brush border membrane PubMed 
    located_in coated vesicle  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in vesicle membrane  

    General protein information

    Preferred Names
    sodium/nucleoside cotransporter 2
    Names
    Na(+)/nucleoside cotransporter 2
    concentrative nucleoside transporter 2
    purine-selective Na+ nucleoside cotransporter
    sodium/purine nucleoside cotransporter

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356532.3NP_001343461.1  sodium/nucleoside cotransporter 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AL844566
      Consensus CDS
      CCDS16663.1
      UniProtKB/Swiss-Prot
      O88627, Q8BJP1
      UniProtKB/TrEMBL
      Q7TMQ0
      Conserved Domains (1) summary
      TIGR00804
      Location:176587
      nupC; nucleoside transporter
    2. NM_001379459.1NP_001366388.1  sodium/nucleoside cotransporter 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AL844566
      UniProtKB/Swiss-Prot
      O88627, Q8BJP1
      UniProtKB/TrEMBL
      Q7TMQ0
      Conserved Domains (1) summary
      TIGR00804
      Location:176587
      nupC; nucleoside transporter
    3. NM_001379460.1NP_001366389.1  sodium/nucleoside cotransporter 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AL844566
      UniProtKB/Swiss-Prot
      O88627, Q8BJP1
      UniProtKB/TrEMBL
      Q7TMQ0
      Conserved Domains (1) summary
      TIGR00804
      Location:176587
      nupC; nucleoside transporter
    4. NM_172980.4NP_766568.1  sodium/nucleoside cotransporter 2

      See identical proteins and their annotated locations for NP_766568.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AL844566
      Consensus CDS
      CCDS16663.1
      UniProtKB/Swiss-Prot
      O88627, Q8BJP1
      UniProtKB/TrEMBL
      Q7TMQ0
      Related
      ENSMUSP00000106154.2, ENSMUST00000110525.8
      Conserved Domains (1) summary
      TIGR00804
      Location:176587
      nupC; nucleoside transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      122256836..122291633
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162243.1XP_036018136.1  sodium/nucleoside cotransporter 2 isoform X1

      UniProtKB/Swiss-Prot
      O88627, Q8BJP1
      UniProtKB/TrEMBL
      Q7TMQ0
      Conserved Domains (1) summary
      TIGR00804
      Location:176587
      nupC; nucleoside transporter
    2. XM_011239577.4XP_011237879.1  sodium/nucleoside cotransporter 2 isoform X3

      Conserved Domains (1) summary
      TIGR00804
      Location:176509
      nupC; nucleoside transporter
    3. XM_036162242.1XP_036018135.1  sodium/nucleoside cotransporter 2 isoform X1

      UniProtKB/Swiss-Prot
      O88627, Q8BJP1
      UniProtKB/TrEMBL
      Q7TMQ0
      Related
      ENSMUSP00000106153.2, ENSMUST00000110524.2
      Conserved Domains (1) summary
      TIGR00804
      Location:176587
      nupC; nucleoside transporter
    4. XM_036162244.1XP_036018137.1  sodium/nucleoside cotransporter 2 isoform X2

      UniProtKB/TrEMBL
      Q7TMQ0
      Conserved Domains (1) summary
      TIGR00804
      Location:96507
      nupC; nucleoside transporter
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