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ZNF14 zinc finger protein 14 [ Homo sapiens (human) ]

Gene ID: 7561, updated on 10-Dec-2024

Summary

Official Symbol
ZNF14provided by HGNC
Official Full Name
zinc finger protein 14provided by HGNC
Primary source
HGNC:HGNC:12924
See related
Ensembl:ENSG00000105708 MIM:194556; AllianceGenome:HGNC:12924
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOX6; GIOT-4
Summary
The protein encoded by this gene contains a zinc finger and a Kruppel-associated box (KRAB) domain. KRAB domain is known to be involved in the transcriptional repression of a number of zinc finger proteins. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 4.5), ovary (RPKM 4.4) and 24 other tissues See more
Orthologs
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Genomic context

See ZNF14 in Genome Data Viewer
Location:
19p13.11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (19710472..19733112, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (19847997..19870637, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (19821281..19843921, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATPase 13A1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:19772231-19772878 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14368 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:19773833-19774815 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10455 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:19779337-19779903 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:19779904-19780469 Neighboring gene zinc finger protein 101 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10457 Neighboring gene uncharacterized LOC101060187 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:19858409-19858910 Neighboring gene sorting nexin 18 pseudogene Neighboring gene long intergenic non-protein coding RNA 663 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14370

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of selenium concentrations.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in nucleus  

General protein information

Preferred Names
zinc finger protein 14
Names
gonadotropin inducible transcription repressor-4
gonadotropin-inducible ovary transcription repressor 4
zinc finger protein 14 (KOX 6)
zinc finger protein KOX6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021030.3NP_066358.2  zinc finger protein 14

    See identical proteins and their annotated locations for NP_066358.2

    Status: REVIEWED

    Source sequence(s)
    AA286756, AB021644, AK074832, AV726241, AW675436, BE392040, BM836276, CA414092, CD358782
    Consensus CDS
    CCDS12409.1
    UniProtKB/Swiss-Prot
    B9EGA4, P17017, Q9ULZ5
    Related
    ENSP00000340514.2, ENST00000344099.4
    Conserved Domains (5) summary
    smart00349
    Location:446
    KRAB; krueppel associated box
    COG5048
    Location:249633
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:443
    KRAB; KRAB box
    pfam13465
    Location:237262
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    19710472..19733112 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    19847997..19870637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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